{"title":"Wild mice for research","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01365-8","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":null,"pages":null},"PeriodicalIF":5.9000,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lab Animal","FirstCategoryId":"97","ListUrlMain":"https://www.nature.com/articles/s41684-024-01365-8","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
几十年来，标准化的近交系小鼠一直是生物医学研究的核心，确保了不同实验室和实验之间的实验可重复性。然而，近交系小鼠内部和之间缺乏遗传多样性是一个重要的局限。发表在《Plos Genetics》上的一项研究报告称，研究人员从北美和南美五个环境不同的地方采集样本，从野生捕获的麝香小鼠（Mus musculus domesticus）中培育出了一组新的 11 个近交系。这些 "纳克曼品系 "蕴藏着数百万个目前实验室小鼠模型所没有的基因变异，在对若干代谢、神经行为、生理、形态和生化特征进行测试时显示出广泛的表型多样性。这一新的野生近交系面板是对现有多样化小鼠面板（如 BXD、合作杂交或杂交小鼠多样性面板）的补充，有助于扩大在实验室小鼠中观察到的性状变异范围：Dumont, B. L. et al.20, e1011228 (2024)
期刊介绍：
LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research.
LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.
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