Osteogenesis and angiogenesis promoting bioactive ceramics

IF 31.6 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Materials Science and Engineering: R: Reports Pub Date : 2024-05-03 DOI:10.1016/j.mser.2024.100801

Arun Kumar Rajendran , Mary Susan J. Anthraper , Nathaniel S. Hwang , Jayakumar Rangasamy

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Abstract

Bioceramics such as hydroxyapatite, bioglass, and magnesium-calcium-phosphate combinations are extensively used for bone tissue regeneration. Although hydroxyapatite possesses inherent osteoconductive capacity that stimulates osteoblast differentiation and bone formation, it lacks the ability for the induction of angiogenesis. Angiogenesis plays a very crucial role in bone tissue regeneration by delivering oxygen, nutrients, and progenitor cells to the site of injury and is essential for bone defect repair and regeneration. Some bioceramics like bioglass, and magnesium whitlockite display angiogenic properties. Metal doping of the above-mentioned bioceramics has been shown to accelerate the osteogenic and angiogenic potential of the biomaterial in in vivo and in vitro studies. The coupling of osteogenesis and angiogenesis has proven to be of great benefit in tissue engineering for enhanced healing of damaged bone tissue. This review gives a brief explanation of the available types of bioceramics and the metal ions doped onto them to achieve enhanced and coupled osteogenesis and angiogenesis.

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促进骨质生成和血管生成的生物活性陶瓷

羟基磷灰石、生物玻璃和镁钙磷酸盐组合等生物陶瓷被广泛用于骨组织再生。尽管羟基磷灰石具有固有的骨诱导能力，可刺激成骨细胞分化和骨形成，但它缺乏诱导血管生成的能力。血管生成可将氧气、营养物质和祖细胞输送到损伤部位，在骨组织再生中发挥着非常关键的作用，对骨缺损的修复和再生至关重要。一些生物陶瓷（如生物玻璃和镁蛭石）具有血管生成特性。在体内和体外研究中，上述生物陶瓷的金属掺杂已被证明可加速生物材料的成骨和血管生成潜能。事实证明，成骨和血管生成的耦合在组织工程中对增强受损骨组织的愈合大有裨益。本综述简要介绍了现有的生物陶瓷类型以及掺入其中的金属离子，以实现成骨和血管生成的增强和耦合。

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来源期刊

Materials Science and Engineering: R: Reports 工程技术-材料科学：综合

CiteScore

60.50

自引率

0.30%

发文量

审稿时长

34 days

期刊介绍： Materials Science & Engineering R: Reports is a journal that covers a wide range of topics in the field of materials science and engineering. It publishes both experimental and theoretical research papers, providing background information and critical assessments on various topics. The journal aims to publish high-quality and novel research papers and reviews. The subject areas covered by the journal include Materials Science (General), Electronic Materials, Optical Materials, and Magnetic Materials. In addition to regular issues, the journal also publishes special issues on key themes in the field of materials science, including Energy Materials, Materials for Health, Materials Discovery, Innovation for High Value Manufacturing, and Sustainable Materials development.