Clinical and neuropsychological correlates of theta-band functional excitation-inhibition ratio in autism: An EEG study

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2024-04-15 DOI:10.1016/j.clinph.2024.04.004

Melody M.Y. Chan , Coco X.T. Choi , Tom C.W. Tsoi , Junpei Zhong , Yvonne M.Y. Han

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Abstract

Objective

How abnormal brain signaling impacts cognition in autism spectrum disorder (ASD) remained elusive. This study aimed to investigate the local and global brain signaling in ASD indicated by theta-band functional excitation-inhibition (fE/I) ratio and explored psychophysiological relationships between fE/I, cognitive deficits, and ASD symptomatology.

Methods

A total of 83 ASD and typically developing (TD) individuals participated in this study. Participants’ interference control and set-shifting abilities were assessed. Resting-state electroencephalography (EEG) was used for estimating theta-band fE/I ratio.

Results

ASD individuals (n = 31 without visual EEG abnormality; n = 22 with visual EEG abnormality) generally performed slower in a cognitive task tapping interference control and set-maintenance abilities, but only ASD individuals with visually abnormal EEG performed significantly slower than their TD counterparts (Bonferroni-corrected ps < .001). Heightened theta-band fE/I ratios at the whole-head level, left and right hemispheres were observed in the ASD subgroup without visual EEG abnormality only (Bonferroni-corrected ps < .001), which remained highly significant when only data from medication-naïve participants were analyzed. In addition, higher left hemispheric fE/I ratios in ASD individuals without visual EEG abnormality were significantly correlated with faster interference control task performance, in turn faster reaction time was significantly associated with less severe restricted, repetitive behavior (Bonferroni-corrected ps ≤ .0017).

Conclusions

Differential theta-band fE/I within the ASD population. Heightened theta-band fE/I in ASD without visual EEG abnormality may be associated with more efficient filtering of distractors and a less severe ASD symptom manifestation.

Significance

Brain signaling, indicated by theta-band fE/I, was different in ASD subgroups. Only ASD with visually-normal EEG showed heightened theta-band fE/I, which was associated with faster processing of visual distractors during a cognitive task. More efficient distractor filtering was associated with less restricted, repetitive behaviors.

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自闭症患者θ波段功能兴奋抑制比的临床和神经心理学相关性：脑电图研究

目的大脑信号异常如何影响自闭症谱系障碍（ASD）患者的认知能力仍是一个未知数。本研究旨在通过θ波段功能兴奋-抑制（fE/I）比值研究自闭症谱系障碍中局部和整体大脑信号传导，并探讨fE/I、认知缺陷和自闭症谱系障碍症状之间的心理生理学关系。研究评估了参与者的干扰控制和集合转换能力。结果ASD个体（n = 31，无视觉脑电图异常；n = 22，有视觉脑电图异常）在认知任务中的表现普遍慢于TD个体（Bonferroni校正ps < .001）。仅在无视觉脑电图异常的 ASD 亚组中观察到整个头部水平、左半球和右半球的 Theta 波段 fE/I 比值升高（Bonferroni 校正 ps <.001），当仅分析药物治疗无效参与者的数据时，该比值仍然非常显著。此外，无视觉脑电图异常的 ASD 患者左半球 fE/I 比率较高与干扰控制任务表现较快有显著相关性，而反应时间较快又与较轻的限制性重复行为有显著相关性（Bonferroni 校正 ps ≤ .0017）。在无视觉脑电图异常的 ASD 患者中，θ 波段 fE/I 的增高可能与更有效地过滤干扰物和较轻的 ASD 症状表现有关。只有视觉脑电图正常的自闭症患者才表现出θ波段fE/I增高，这与认知任务中处理视觉干扰物的速度加快有关。更有效的分心过滤与更少的限制性重复行为有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.