Clinical Neurophysiology最新文献

英文中文

Amplitude coupling is altered in delirium of various etiologies: Results from a retrospective multi-center case-control EEG study

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-03-11 DOI: 10.1016/j.clinph.2025.02.266

Robert Fleischmann , Annerose Mengel , Cornelis J. Stam , Sophie Leroy , Pauline Schneider , Arjen J.C. Slooter , Johannes Ehler , Edwin van Dellen

Objective

Delirium manifests with comparable clinical presentations, regardless of its heterogeneous etiology. This suggests a final common pathway such as decreased electroencephalography (EEG) phase coupling. This study investigates if amplitude coupling, another mode of neural communication, is altered in delirium due to different etiologies.

Methods

We analyzed EEGs of patients from three sites with either postoperative, poststroke or medical delirium and non-delirious control patients. Amplitude envelope correlation corrected for spatial leakage (AECc) was calculated and Mann-Whitney U-tests were used to compare patients with or without delirium. AECc differences among delirium types were compared using Kruskal-Wallis tests.

Results

AECc was significantly increased in delirious (n = 173, age 79.2±9.3 years, 46 % female) as compared to non-delirious (n = 204, age 72.9±13.1 years, 45 % female) patients in the delta (median, effect size of difference: 0.16 vs. 0.12, r = 0.28, p < 0.01) and beta band (0.11 vs. 0.09, r = 0.14, p = 0.04). These changes did not differ among delirium types (p > 0.05).

Conclusions

We found modestly higher delta and beta band AECc in delirium compared to non-delirious control patients, regardless of the presumed etiology.

Significance

This study provides evidence for altered amplitude coupling as mode of impaired neuronal communication in delirium, the role of which should be investigated in future studies of neural network pathophysiology.

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引用次数: 0

Role of the premotor and the precentral negative motor area in praxis: A direct electrical stimulation study with behavioral analysis

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-03-10 DOI: 10.1016/j.clinph.2025.03.008

Masaya Togo , Riki Matsumoto , Akihiro Shimotake , Tamaki Kobayashi , Takuro Nakae , Katsuya Kobayashi , Kiyohide Usami , Takayuki Kikuchi , Kazumichi Yoshida , Masao Matsuhashi , Takeharu Kunieda , Susumu Miyamoto , Ryosuke Takahashi , Akio Ikeda

Objective

Although the negative motor area (NMA) is defined as the area where electrical cortical stimulation inhibits voluntary movements, detail functions of NMA on praxis have not been elucidated. We investigated its role in praxis by motion analysis during stimulation at a smaller intensity.

Methods

Patients were six intractable partial epilepsy patients undergoing implantation of intracranial electrodes. Motion impairments by stimulation were studied in finger tapping, reach-to-grasp, finger gesture, and pantomime of tool use.

Results

NMAs were identified on the precentral gyrus (4 patients), ventral premotor area (1), and at their border (1). In patients with precentral NMA, quantitative analysis revealed decreased tapping stroke and grasping aperture, while reaching velocity and pantomime did not change. As for more rostral NMA, quantitative stroke, aperture, and reaching velocity were decreased. One patient showed the arrest of finger gestures and pantomime, and the other had prolongation of reaction time. These two NMAs showed distinct connectivity pattern in connectivity analysis.

Conclusions

Precentral NMA seemed to play a role in elementary finger movement control, whereas more rostral NMA in complex movement. The findings indicate functional differences within NMAs. Significance: These findings elucidated the contribution of the human premotor area to the highly skilled hand movements.

{"title":"Role of the premotor and the precentral negative motor area in praxis: A direct electrical stimulation study with behavioral analysis","authors":"Masaya Togo , Riki Matsumoto , Akihiro Shimotake , Tamaki Kobayashi , Takuro Nakae , Katsuya Kobayashi , Kiyohide Usami , Takayuki Kikuchi , Kazumichi Yoshida , Masao Matsuhashi , Takeharu Kunieda , Susumu Miyamoto , Ryosuke Takahashi , Akio Ikeda","doi":"10.1016/j.clinph.2025.03.008","DOIUrl":"10.1016/j.clinph.2025.03.008","url":null,"abstract":"<div><h3>Objective</h3><div>Although the negative motor area (NMA) is defined as the area where electrical cortical stimulation inhibits voluntary movements, detail functions of NMA on praxis have not been elucidated. We investigated its role in praxis by motion analysis during stimulation at a smaller intensity.</div></div><div><h3>Methods</h3><div>Patients were six intractable partial epilepsy patients undergoing implantation of intracranial electrodes. Motion impairments by stimulation were studied in finger tapping, reach-to-grasp, finger gesture, and pantomime of tool use.</div></div><div><h3>Results</h3><div>NMAs were identified on the precentral gyrus (4 patients), ventral premotor area (1), and at their border (1). In patients with precentral NMA, quantitative analysis revealed decreased tapping stroke and grasping aperture, while reaching velocity and pantomime did not change. As for more rostral NMA, quantitative stroke, aperture, and reaching velocity were decreased. One patient showed the arrest of finger gestures and pantomime, and the other had prolongation of reaction time. These two NMAs showed distinct connectivity pattern in connectivity analysis.</div></div><div><h3>Conclusions</h3><div>Precentral NMA seemed to play a role in elementary finger movement control, whereas more rostral NMA in complex movement. The findings indicate functional differences within NMAs. Significance: These findings elucidated the contribution of the human premotor area to the highly skilled hand movements.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"173 ","pages":"Pages 66-75"},"PeriodicalIF":3.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early peripheral nerve impairments in type 1 diabetes are associated with cortical inhibition of ankle joint proprioceptive afference

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-03-10 DOI: 10.1016/j.clinph.2025.02.277

Toni Mujunen , Urho Sompa , Miguel Muñoz-Ruiz , Elina Monto , Valtteri Rissanen , Heli Ruuskanen , Petteri Ahtiainen , Harri Piitulainen

Objective

Diabetic sensorimotor peripheral neuropathy (DSPN) is a common complication of type 1 diabetes mellitus (T1DM). However, it is still unclear how the cortical processing of proprioceptive afference is altered due to DSPN.

Methods

Cortical responses to right and left ankle joint rotations were recorded with magnetoencephalography and pooled together in 20 T1DM participants and 20 healthy controls for source space comparisons. T1DM participants also underwent a lower limb nerve–conduction study to correlate peripheral nerve function with the cortical responses.

Results

Primary sensorimotor (SM1) cortex activation was wider in T1DM patients during beta suppression, with no between–group differences in the response strength. However, stronger beta suppressions in T1DM patients were correlated with axon–loss in the peripheral sensory afferents (p < 0.05). Weaker beta rebounds and stronger SM1 evoked field amplitudes were associated with impaired conduction velocities in the mixed nerves (p < 0.05). Lastly, stronger SM1 beta power was associated with both demyelination and axon–loss in the lower limb sensory afferents (p < 0.05).

Conclusions

T1DM is accompanied with wider SM1 cortex activation to proprioceptive stimuli, and the early asymptomatic DSPN impairments are linked to increased levels of cortical inhibition.

Significance

T1DM is associated with comprehensive central pathophysiology evident in early DSPN.

{"title":"Early peripheral nerve impairments in type 1 diabetes are associated with cortical inhibition of ankle joint proprioceptive afference","authors":"Toni Mujunen , Urho Sompa , Miguel Muñoz-Ruiz , Elina Monto , Valtteri Rissanen , Heli Ruuskanen , Petteri Ahtiainen , Harri Piitulainen","doi":"10.1016/j.clinph.2025.02.277","DOIUrl":"10.1016/j.clinph.2025.02.277","url":null,"abstract":"<div><h3>Objective</h3><div>Diabetic sensorimotor peripheral neuropathy (DSPN) is a common complication of type 1 diabetes mellitus (T1DM). However, it is still unclear how the cortical processing of proprioceptive afference is altered due to DSPN.</div></div><div><h3>Methods</h3><div>Cortical responses to right and left ankle joint rotations were recorded with magnetoencephalography and pooled together in 20 T1DM participants and 20 healthy controls for source space comparisons. T1DM participants also underwent a lower limb nerve–conduction study to correlate peripheral nerve function with the cortical responses.</div></div><div><h3>Results</h3><div>Primary sensorimotor (SM1) cortex activation was wider in T1DM patients during beta suppression, with no between–group differences in the response strength. However, stronger beta suppressions in T1DM patients were correlated with axon–loss in the peripheral sensory afferents (<em>p</em> < 0.05). Weaker beta rebounds and stronger SM1 evoked field amplitudes were associated with impaired conduction velocities in the mixed nerves (<em>p</em> < 0.05). Lastly, stronger SM1 beta power was associated with both demyelination and axon–loss in the lower limb sensory afferents (<em>p</em> < 0.05).</div></div><div><h3>Conclusions</h3><div>T1DM is accompanied with wider SM1 cortex activation to proprioceptive stimuli, and the early asymptomatic DSPN impairments are linked to increased levels of cortical inhibition.</div></div><div><h3>Significance</h3><div>T1DM is associated with comprehensive central pathophysiology evident in early DSPN.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"173 ","pages":"Pages 99-112"},"PeriodicalIF":3.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New double homozygous GDAP1 variations associated with polyneuropathy and prominent inflammatory features in unrelated individuals from Indian Ocean islands

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-03-10 DOI: 10.1016/j.clinph.2025.02.263

P-A. Faye , C. Magdelaine , C. Espil , C. Loret , C. Scherrer , P. Chazelas , K. Ghorab , L. Richard , F. Favreau , A-S. Lia , L. Magy

引用次数: 0

Dynamic ultrasonographic findings of tongue myokymia in anti-IgLON5 disease: A non-invasive electrophysiologic correlate

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-03-10 DOI: 10.1016/j.clinph.2025.03.001

James B Meiling , Brian A Crum

引用次数: 0

Relationship between scalp high-frequency oscillations and time since the last seizure in epilepsy

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-03-10 DOI: 10.1016/j.clinph.2025.03.007

Keisuke Maeda , Nami Hosoda , Junichi Fukumoto , Himari Tsuboi , Honoka Naitou , Chiaki Kudou , Tomoko Hannya , Shiho Fujita , Naohiro Ichino , Keisuke Osakabe , Keiko Sugimoto , Gen Furukawa , Naoko Ishihara

Objective

The accuracy of self-reported seizure-freedom duration are essentially limited. Scalp high-frequency oscillations (HFOs) are more tightly linked to seizures than spikes alone and are a promising new biomarker. The purpose of this study is to determine the relationship between scalp HFO and time since the last reported seizure.

Methods

The study population consisted of 169 pediatric epilepsy patients (91 males; age range, 0–20 years). A holdout method was used to develop and validate a predictive model (multivariate HFO model) to estimate the time since the last reported seizure.

Results

The multivariate HFO model was created with four variables: scalp HFO detection rate, developmental delay, epilepsy duration, and the use of antiepileptic drugs. The area under the curve (AUC) of the multivariate HFO model was higher than that for the HFO and spike models in all four discriminations for time since the last reported seizure (≥ 2 years: AUC = 0.95, ≥ 1 year: 0.91, ≥ 2 months: 0.82, and ≥ 2 weeks: 0.76).

Conclusions

The multivariate HFO model showed higher performance in patients with a longer time since the last reported seizure (≥ 1 year).

Significance

This model may help establish a new measure of epilepsy remission.

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引用次数: 0

Clinical programming can limit access to binaural cues in children with bilateral cochlear implants

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-03-10 DOI: 10.1016/j.clinph.2025.02.271

Angela L. Fung , Alan W. Blakeman , Robel Z. Alemu , Jaina Negandhi , Sharon L. Cushing , Blake C. Papsin , Karen A. Gordon

Objective

In children with bilateral cochlear implants(CIs): 1) quantify cortical access and sensitivity to inter-aural level differences(ILDs); 2) determine if cortical ILD detection predicts ILD perception; and 3) assess demographic and clinical factors that could limit ILD access.

Methods

Cortical detection responses evoked by ILD changes were measured in 22/24 children with bilateral CIs(7 female) using their clinically programmed devices and in 8 children(3 female) with normal hearing. Behavioral lateralization(left vs right perception) to ILDs was also measured.

Results

Increased cortical sensitivity(amplitude) to ILD changes did not predict more accurate behavioral perception; rather children with CIs were able to lateralize ILDs with fair accuracy but with increased cognitive effort(reaction times) compared to normal hearing children (p = 0.0004, Cohen’s d = 1.17). While demographic factors did not significantly contribute to response measures, symmetry of programmed levels in the left and right CIs predicted better cortical and behavioral sensitivity to ILDs (ps < 0.05).

Conclusions

the developing auditory system can detect ILD cues when provided with bilateral cochlear implants; however, this access can be altered by programming and may not translate to normal binaural processing.

Significance

There is potential for clinical programming to improve spatial hearing in children with bilateral CIs.

{"title":"Clinical programming can limit access to binaural cues in children with bilateral cochlear implants","authors":"Angela L. Fung , Alan W. Blakeman , Robel Z. Alemu , Jaina Negandhi , Sharon L. Cushing , Blake C. Papsin , Karen A. Gordon","doi":"10.1016/j.clinph.2025.02.271","DOIUrl":"10.1016/j.clinph.2025.02.271","url":null,"abstract":"<div><h3>Objective</h3><div>In children with bilateral cochlear implants(CIs): 1) quantify cortical access and sensitivity to inter-aural level differences(ILDs); 2) determine if cortical ILD detection predicts ILD perception; and 3) assess demographic and clinical factors that could limit ILD access.</div></div><div><h3>Methods</h3><div>Cortical detection responses evoked by ILD changes were measured in 22/24 children with bilateral CIs(7 female) using their clinically programmed devices and in 8 children(3 female) with normal hearing. Behavioral lateralization(left vs right perception) to ILDs was also measured.</div></div><div><h3>Results</h3><div>Increased cortical sensitivity(amplitude) to ILD changes did not predict more accurate behavioral perception; rather children with CIs were able to lateralize ILDs with fair accuracy but with increased cognitive effort(reaction times) compared to normal hearing children (<em>p</em> = 0.0004, <em>Cohen’s d</em> = 1.17). While demographic factors did not significantly contribute to response measures, symmetry of programmed levels in the left and right CIs predicted better cortical and behavioral sensitivity to ILDs (<em>ps</em> < 0.05).</div></div><div><h3>Conclusions</h3><div>the developing auditory system can detect ILD cues when provided with bilateral cochlear implants; however, this access can be altered by programming and may not translate to normal binaural processing.</div></div><div><h3>Significance</h3><div>There is potential for clinical programming to improve spatial hearing in children with bilateral CIs.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"173 ","pages":"Pages 52-63"},"PeriodicalIF":3.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combining MEG with fMRI reveal complementary brain activity elicited by verbal fluency tasks performed by neurotypical adults. 将 MEG 与 fMRI 相结合，可揭示神经畸形成人在完成语言流利性任务时所引发的互补性大脑活动。

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-03-10 DOI: 10.1016/j.clinph.2025.03.005

Stavros I Dimitriadis

引用次数: 0

Finding a new normal: Thalamic stereo EEG reveals physiological fast ripples.

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-03-10 DOI: 10.1016/j.clinph.2025.03.004

William C Stacey

引用次数: 0

Sarcolemmal dysfunction in facioscapulohumeral dystrophy: An assessment using muscle velocity recovery cycles

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology

Pub Date : 2025-03-10 DOI: 10.1016/j.clinph.2025.02.272

Mitchell J. Lycett , Kishore R. Kumar , Christina Liang , Karl Ng

Objective

There is a need to develop novel facioscapulohumeral dystrophy (FSHD) biomarkers for use in clinical trials. We examined the muscle excitability properties in FSHD and their use as biomarkers of disease severity.

Methods

Muscle velocity recovery cycle (MVRC) and frequency ramp recordings were performed on the tibialis anterior (TA) and trapezius muscles in subjects with FSHD. Markers of disease severity including symptom severity, muscle dynamometry and the FSHD-COM functional scale were recorded for disease correlation. Recordings from 20 FSHD subjects were compared to 74 TA and 33 trapezius normal controls.

Results

FSHD recordings from distal and proximal muscles demonstrated significantly reduced early and late muscle supernormality measures. There was a moderate correlation between late supernormality changes multiple conditioning in the trapezius and quadriceps dynamometry. Frequency ramp latency changes were significantly blunted in FSHD subjects.

Conclusions

The findings are consistent with resting muscle membrane potential depolarisation, but correlations with markers of disease severity were limited.

Significance

The pathophysiology of FSHD involves not only ultrastructural changes to muscle and its supporting structures, but functional changes in the electrical properties of the muscle membrane. Muscle membrane properties are perturbed early in the disease course, and could be considered as a potential disease biomarker.

{"title":"Sarcolemmal dysfunction in facioscapulohumeral dystrophy: An assessment using muscle velocity recovery cycles","authors":"Mitchell J. Lycett , Kishore R. Kumar , Christina Liang , Karl Ng","doi":"10.1016/j.clinph.2025.02.272","DOIUrl":"10.1016/j.clinph.2025.02.272","url":null,"abstract":"<div><h3>Objective</h3><div>There is a need to develop novel facioscapulohumeral dystrophy (FSHD) biomarkers for use in clinical trials. We examined the muscle excitability properties in FSHD and their use as biomarkers of disease severity.</div></div><div><h3>Methods</h3><div>Muscle velocity recovery cycle (MVRC) and frequency ramp recordings were performed on the tibialis anterior (TA) and trapezius muscles in subjects with FSHD. Markers of disease severity including symptom severity, muscle dynamometry and the FSHD-COM functional scale were recorded for disease correlation. Recordings from 20 FSHD subjects were compared to 74 TA and 33 trapezius normal controls.</div></div><div><h3>Results</h3><div>FSHD recordings from distal and proximal muscles demonstrated significantly reduced early and late muscle supernormality measures. There was a moderate correlation between late supernormality changes multiple conditioning in the trapezius and quadriceps dynamometry. Frequency ramp latency changes were significantly blunted in FSHD subjects.</div></div><div><h3>Conclusions</h3><div>The findings are consistent with resting muscle membrane potential depolarisation, but correlations with markers of disease severity were limited.</div></div><div><h3>Significance</h3><div>The pathophysiology of FSHD involves not only ultrastructural changes to muscle and its supporting structures, but functional changes in the electrical properties of the muscle membrane. Muscle membrane properties are perturbed early in the disease course, and could be considered as a potential disease biomarker.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"173 ","pages":"Pages 86-95"},"PeriodicalIF":3.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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