Antiviral and anti-inflammatory activities of chemical constituents from twigs of Mosla chinensis Maxim

IF 4.8 3区化学 Q1 CHEMISTRY, MEDICINAL Natural Products and Bioprospecting Pub Date : 2024-05-01 DOI:10.1007/s13659-024-00448-w

Shi-Yan Feng, Na Jiang, Jia-Ying Yang, Lin-Yao Yang, Jiang-Chao Du, Xuan-Qin Chen, Dan Liu, Rong-Tao Li, Jin-Dong Zhong

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Abstract

Seven undescribed compounds, including three flavones (1–3), one phenylpropanoid (19), three monoaromatic hydrocarbons (27–29), were isolated from the twigs of Mosla chinensis Maxim together with twenty-eight known compounds. The structures were characterized by HRESIMS, 1D and 2D NMR, and ECD spectroscopic techniques. Compound 20 displayed the most significant activity against A/WSN/33/2009 (H1N1) virus (IC₅₀ = 20.47 μM) compared to the positive control oseltamivir (IC₅₀ = 6.85 µM). Further research on the anti-influenza mechanism showed that compound 20 could bind to H1N1 virus surface antigen HA1 and inhibit the early attachment stage of the virus. Furthermore, compounds 9, 22, 23, and 25 displayed moderate inhibitory effects on the NO expression in LPS inducing Raw 264.7 cells with IC₅₀ values of 22.78, 20.47, 27.66, and 30.14 µM, respectively.

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Mosla chinensis Maxim 树枝中化学成分的抗病毒和抗炎活性

从 Mosla chinensis Maxim 的树枝中分离出了 7 种未曾描述过的化合物，包括 3 种黄酮类化合物（1-3）、1 种苯丙类化合物（19）、3 种单芳烃类化合物（27-29），以及 28 种已知化合物。通过 HRESIMS、1D 和 2D NMR 以及 ECD 光谱技术对这些化合物的结构进行了表征。与阳性对照奥司他韦（IC50 = 6.85 µM）相比，化合物 20 对 A/WSN/33/2009 (H1N1) 病毒具有最显著的活性（IC50 = 20.47 µM）。对抗流感机理的进一步研究表明，化合物 20 能与 H1N1 病毒表面抗原 HA1 结合，抑制病毒的早期附着阶段。此外，化合物 9、22、23 和 25 对 LPS 诱导的 Raw 264.7 细胞中的 NO 表达有中度抑制作用，IC50 值分别为 22.78、20.47、27.66 和 30.14 µM。

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来源期刊

Natural Products and Bioprospecting CHEMISTRY, MEDICINAL-

CiteScore

8.30

自引率

2.10%

发文量

审稿时长

13 weeks

期刊介绍： Natural Products and Bioprospecting serves as an international forum for essential research on natural products and focuses on, but is not limited to, the following aspects: Natural products: isolation and structure elucidation Natural products: synthesis Biological evaluation of biologically active natural products Bioorganic and medicinal chemistry Biosynthesis and microbiological transformation Fermentation and plant tissue cultures Bioprospecting of natural products from natural resources All research articles published in this journal have undergone rigorous peer review. In addition to original research articles, Natural Products and Bioprospecting publishes reviews and short communications, aiming to rapidly disseminate the research results of timely interest, and comprehensive reviews of emerging topics in all the areas of natural products. It is also an open access journal, which provides free access to its articles to anyone, anywhere.