Illuminating cortactin structure and function at actin filament branches

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Nature Structural & Molecular Biology Pub Date : 2024-05-07 DOI:10.1038/s41594-024-01297-4

Klemens Rottner, Peter Bieling

引用次数: 0

Abstract

Stabilization of a branch structure would intuitively suggest a direct connection between trunk and bough, but in actin filament networks, cortactin clamps the branching Arp2/3 complex to the daughter filament. This has fundamental consequences for mechanistic understanding of actin branch turnover and cortactin biology.

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阐明肌动蛋白丝分支上的皮质联系蛋白结构和功能

分支结构的稳定直观地表明树干和枝桠之间存在直接联系，但在肌动蛋白丝网络中，cortactin 将分支 Arp2/3 复合物夹在子丝上。这对从机理上理解肌动蛋白分支周转和皮质联系蛋白生物学具有根本性的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.

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