Associations between subjective social status and predictors of interest in genetic testing among women diagnosed with breast cancer at a young age.

IF 2.2 4区医学 Q3 ONCOLOGY Cancer Causes & Control Pub Date : 2024-08-01 Epub Date: 2024-05-03 DOI:10.1007/s10552-024-01878-0

Jonathan N Odumegwu, Daniel Chavez-Yenter, Melody S Goodman, Kimberly A Kaphingst

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Abstract

Purpose: Genetic testing for gene mutations which elevate risk for breast cancer is particularly important for women diagnosed at a young age. Differences remain in access and utilization to testing across social groups, and research on the predictors of interest in genetic testing for women diagnosed at a young age is limited.

Methods: We examined the relationships between subjective social status (SSS) and variables previously identified as possible predictors of genetic testing, including genome sequencing knowledge, genetic worry, cancer worry, health consciousness, decision-making preferences, genetic self-efficacy, genetic-related beliefs, and subjective numeracy, among a cohort of women who were diagnosed with breast cancer at a young age.

Results: In this sample (n = 1,076), those who had higher SSS had significantly higher knowledge about the limitations of genome sequencing (Odds Ratio (OR) = 1.11; 95% CI = 1.01-1.21) and significantly higher informational norms (OR = 1.93; 95% CI = 1.19-3.14) than those with lower SSS. Similarly, education (OR = 2.75; 95% CI = 1.79-4.22), health status (OR = 2.18; 95% CI = 1.44-3.31) were significant predictors among higher SSS women compared to lower SSS women in our multivariate analysis. Lower SSS women with low self-reported income (OR = 0.13; 95% CI = 0.08-0.20) had lower odds of genetic testing interest. Our results are consistent with some prior research utilizing proxy indicators for socioeconomic status, but our research adds the importance of using a multidimensional indicator such as SSS to examine cancer and genetic testing predictor outcomes.

Conclusion: To develop interventions to improve genetic knowledge, researchers should consider the social status and contexts of women diagnosed with breast cancer at a young age (or before 40 years old) to ensure equity in the distribution of genetic testing benefits.

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年轻时被诊断出患有乳腺癌的妇女的主观社会地位与基因检测兴趣预测因素之间的关系。

目的：基因突变会增加罹患乳腺癌的风险，因此对年轻女性进行基因检测尤为重要。不同社会群体在接受和利用基因检测方面仍存在差异，而有关年轻女性对基因检测兴趣的预测因素的研究却很有限：我们研究了主观社会地位（SSS）与之前被确定为基因检测可能预测因素的变量之间的关系，这些变量包括基因组测序知识、基因担忧、癌症担忧、健康意识、决策偏好、基因自我效能感、基因相关信念以及主观算术能力：在该样本（n = 1,076）中，与 SSS 值较低者相比，SSS 值较高者对基因组测序局限性的了解程度明显更高（Odds Ratio (OR) = 1.11; 95% CI = 1.01-1.21），信息规范（OR = 1.93; 95% CI = 1.19-3.14）也明显更高。同样，在我们的多变量分析中，教育程度（OR = 2.75；95% CI = 1.79-4.22）和健康状况（OR = 2.18；95% CI = 1.44-3.31）也是高 SSS 妇女比低 SSS 妇女的重要预测因素。自我报告收入较低的 SSS 较低女性（OR = 0.13；95% CI = 0.08-0.20）对基因检测感兴趣的几率较低。我们的研究结果与之前一些利用社会经济地位替代指标的研究结果一致，但我们的研究增加了使用多维指标（如 SSS）来研究癌症和基因检测预测结果的重要性：为了制定干预措施以提高基因知识，研究人员应考虑在年轻时（或 40 岁之前）被诊断出患有乳腺癌的妇女的社会地位和背景，以确保基因检测利益分配的公平性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Causes & Control 医学-公共卫生、环境卫生与职业卫生

CiteScore

3.90

自引率

4.30%

发文量

130

审稿时长

6.6 months

期刊介绍： Cancer Causes & Control is an international refereed journal that both reports and stimulates new avenues of investigation into the causes, control, and subsequent prevention of cancer. By drawing together related information published currently in a diverse range of biological and medical journals, it has a multidisciplinary and multinational approach. The scope of the journal includes: variation in cancer distribution within and between populations; factors associated with cancer risk; preventive and therapeutic interventions on a population scale; economic, demographic, and health-policy implications of cancer; and related methodological issues. The emphasis is on speed of publication. The journal will normally publish within 30 to 60 days of acceptance of manuscripts. Cancer Causes & Control publishes Original Articles, Reviews, Commentaries, Opinions, Short Communications and Letters to the Editor which will have direct relevance to researchers and practitioners working in epidemiology, medical statistics, cancer biology, health education, medical economics and related fields. The journal also contains significant information for government agencies concerned with cancer research, control and policy.