Targeting inflammasomes and pyroptosis in retinal diseases—molecular mechanisms and future perspectives

IF 18.6 1区医学 Q1 OPHTHALMOLOGY Progress in Retinal and Eye Research Pub Date : 2024-04-23 DOI:10.1016/j.preteyeres.2024.101263

Yimeng Sun , Fan Li , Yunfei Liu , Dijie Qiao , Xinyu Yao , Guei-Sheung Liu , Dequan Li , Chuanle Xiao , Tao Wang , Wei Chi

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Abstract

Retinal diseases encompass various conditions associated with sight-threatening immune responses and are leading causes of blindness worldwide. These diseases include age-related macular degeneration, diabetic retinopathy, glaucoma and uveitis. Emerging evidence underscores the vital role of the innate immune response in retinal diseases, beyond the previously emphasized T-cell-driven processes of the adaptive immune system. In particular, pyroptosis, a newly discovered programmed cell death process involving inflammasome formation, has been implicated in the loss of membrane integrity and the release of inflammatory cytokines. Several disease-relevant animal models have provided evidence that the formation of inflammasomes and the induction of pyroptosis in innate immune cells contribute to inflammation in various retinal diseases. In this review article, we summarize current knowledge about the innate immune system and pyroptosis in retinal diseases. We also provide insights into translational targeting approaches, including novel drugs countering pyroptosis, to improve the diagnosis and treatment of retinal diseases.

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以视网膜疾病中的炎性体和热变性为靶点--分子机制和未来展望。

视网膜疾病包括各种与危及视力的免疫反应相关的疾病，是全球失明的主要原因。这些疾病包括老年黄斑变性、糖尿病视网膜病变、青光眼和葡萄膜炎。新出现的证据强调了先天性免疫反应在视网膜疾病中的重要作用，而不是以前强调的适应性免疫系统的 T 细胞驱动过程。特别是，新发现的涉及炎性体形成的程序性细胞死亡过程--嗜热症，已被认为与膜完整性的丧失和炎性细胞因子的释放有关。一些与疾病相关的动物模型已经提供了证据，证明先天性免疫细胞中炎性小体的形成和诱导的热凋亡是导致各种视网膜疾病的炎症的原因。在这篇综述文章中，我们总结了目前有关先天性免疫系统和视网膜疾病中的热蛋白沉积的知识。我们还深入探讨了转化靶向方法，包括对抗热蛋白沉积的新型药物，以改善视网膜疾病的诊断和治疗。

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来源期刊

Progress in Retinal and Eye Research 医学-眼科学

CiteScore

34.10

自引率

5.10%

发文量

期刊介绍： Progress in Retinal and Eye Research is a Reviews-only journal. By invitation, leading experts write on basic and clinical aspects of the eye in a style appealing to molecular biologists, neuroscientists and physiologists, as well as to vision researchers and ophthalmologists. The journal covers all aspects of eye research, including topics pertaining to the retina and pigment epithelial layer, cornea, tears, lacrimal glands, aqueous humour, iris, ciliary body, trabeculum, lens, vitreous humour and diseases such as dry-eye, inflammation, keratoconus, corneal dystrophy, glaucoma and cataract.