A Systematic Review of Proteomics in Obesity: Unpacking the Molecular Puzzle.

IF 9.5 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Current Obesity Reports Pub Date : 2024-09-01 Epub Date: 2024-05-04 DOI:10.1007/s13679-024-00561-4
Alba Rodriguez-Muñoz, Hanieh Motahari-Rad, Laura Martin-Chaves, Javier Benitez-Porres, Jorge Rodriguez-Capitan, Andrés Gonzalez-Jimenez, Maria Insenser, Francisco J Tinahones, Mora Murri
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Abstract

Purpose of review: The present study aims to review the existing literature to identify pathophysiological proteins in obesity by conducting a systematic review of proteomics studies. Proteomics may reveal the mechanisms of obesity development and clarify the links between obesity and related diseases, improving our comprehension of obesity and its clinical implications.

Recent findings: Most of the molecular events implicated in obesity development remain incomplete. Proteomics stands as a powerful tool for elucidating the intricate interactions among proteins in the context of obesity. This methodology has the potential to identify proteins involved in pathological processes and to evaluate changes in protein abundance during obesity development, contributing to the identification of early disease predisposition, monitoring the effectiveness of interventions and improving disease management overall. Despite many non-targeted proteomic studies exploring obesity, a comprehensive and up-to-date systematic review of the molecular events implicated in obesity development is lacking. The lack of such a review presents a significant challenge for researchers trying to interpret the existing literature. This systematic review was conducted following the PRISMA guidelines and included sixteen human proteomic studies, each of which delineated proteins exhibiting significant alterations in obesity. A total of 41 proteins were reported to be altered in obesity by at least two or more studies. These proteins were involved in metabolic pathways, oxidative stress responses, inflammatory processes, protein folding, coagulation, as well as structure/cytoskeleton. Many of the identified proteomic biomarkers of obesity have also been reported to be dysregulated in obesity-related disease. Among them, seven proteins, which belong to metabolic pathways (aldehyde dehydrogenase and apolipoprotein A1), the chaperone family (albumin, heat shock protein beta 1, protein disulfide-isomerase A3) and oxidative stress and inflammation proteins (catalase and complement C3), could potentially serve as biomarkers for the progression of obesity and the development of comorbidities, contributing to personalized medicine in the field of obesity. Our systematic review in proteomics represents a substantial step forward in unravelling the complexities of protein alterations associated with obesity. It provides valuable insights into the pathophysiological mechanisms underlying obesity, thereby opening avenues for the discovery of potential biomarkers and the development of personalized medicine in obesity.

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92 肥胖症蛋白质组学系统综述:揭开分子之谜
综述目的:本研究旨在对现有文献进行回顾,通过对蛋白质组学研究进行系统回顾,确定肥胖症中的病理生理蛋白质。蛋白质组学可揭示肥胖症的发病机制,阐明肥胖症与相关疾病之间的联系,从而提高我们对肥胖症及其临床影响的认识:最近的研究结果:大多数与肥胖症发展有关的分子事件仍不完整。蛋白质组学是阐明肥胖症中蛋白质之间错综复杂的相互作用的有力工具。这种方法有可能识别参与病理过程的蛋白质,并评估肥胖发展过程中蛋白质丰度的变化,从而有助于识别早期疾病易感性、监测干预措施的效果并全面改善疾病管理。尽管有许多探讨肥胖症的非靶向蛋白质组学研究,但对肥胖症发展过程中的分子事件缺乏全面、最新的系统综述。缺乏这样的综述给试图解读现有文献的研究人员带来了巨大挑战。本系统性综述按照 PRISMA 指南进行,包括 16 项人类蛋白质组学研究,每项研究都描述了在肥胖症中表现出显著变化的蛋白质。至少有两项或两项以上的研究报告称,共有 41 种蛋白质在肥胖症中发生了改变。这些蛋白质涉及新陈代谢途径、氧化应激反应、炎症过程、蛋白质折叠、凝血以及结构/骨骼。据报道,许多已确定的肥胖症蛋白质组生物标志物在肥胖相关疾病中也出现失调。其中,属于代谢途径(醛脱氢酶和脂蛋白A1)、伴侣蛋白家族(白蛋白、热休克蛋白β1、蛋白二硫异构酶A3)以及氧化应激和炎症蛋白(过氧化氢酶和补体C3)的7种蛋白质有可能成为肥胖症进展和合并症发展的生物标志物,为肥胖症领域的个性化医疗做出贡献。我们的蛋白质组学系统性综述在揭示与肥胖相关的蛋白质变化的复杂性方面迈出了一大步。它为了解肥胖症的病理生理机制提供了宝贵的见解,从而为发现潜在的生物标记物和开发肥胖症的个性化医疗开辟了道路。
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来源期刊
Current Obesity Reports
Current Obesity Reports Medicine-General Medicine
CiteScore
16.40
自引率
1.10%
发文量
25
期刊介绍: The main objective of Current Obesity Reports is to provide expert review articles on recent advancements in the interdisciplinary field of obesity research. Our aim is to offer clear, insightful, and balanced contributions that will benefit all individuals involved in the treatment and prevention of obesity, as well as related conditions such as cardiovascular diseases, endocrine disorders, gynecological issues, cancer, mental health, respiratory complications, and rheumatological diseases. We strive to redefine the way knowledge is expressed and provide organized content for the benefit of our readership.
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