Long Term Impact of Adeno-tonsillectomy on Immunity Against Respiratory Viral Infections; Evidence Deduced During COVID-19 Pandemic.

IF 2 4区医学 Q2 PEDIATRICS Indian Journal of Pediatrics Pub Date : 2025-04-01 Epub Date: 2024-05-07 DOI:10.1007/s12098-024-05125-x

Ramaneeshwaran Murugesan, Prem Sagar, Rajeev Kumar, Sushil Kumar Kabra, Pradeep Kumar Chaturvedi, Maroof Ahmad Khan, Chirom Amit Singh, Rakesh Kumar, Alok Thakar

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Abstract

Objectives: To evaluate the risk of acquiring COVID-19 infection in patients who have undergone adeno-tonsillectomy (AT) as compared to their siblings.

Methods: In this bidirectional cohort control study, 36 cohorts, younger than 18 y, who underwent AT, and 27 controls (siblings of the enrolled cohorts, younger than 18 y) were recruited. Incidence of COVID-19 was analyzed by symptoms suggestive of COVID-19 infection, COVID-19 testing, and SARS-CoV-2 specific antibody measurement.

Results: In the cohort group, the overall COVID-19 positivity rate was 80.5% (n = 29/36) and symptomatic COVID-19 positivity rate was 68.9% (n = 20/29). Among the controls, the overall COVID-19 positivity rate was 44% (n = 12/27) and symptomatic COVID-19 positivity rate was 16% (n = 2/12). The cohorts had 1.8 times higher risk of contracting COVID-19 infection and the relative risk of symptomatic COVID-19 infections as compared to controls was 4.14.

Conclusions: This pilot study indicates that adeno-tonsillectomy poses children at a significantly higher risk of COVID-19 infections and likely other viral upper respiratory tract infections.

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腺样体扁桃体切除术对呼吸道病毒感染免疫力的长期影响；COVID-19 大流行期间的证据推断。

目的评估腺样体扁桃体切除术（AT）患者与其兄弟姐妹感染 COVID-19 的风险：在这项双向队列对照研究中，共招募了 36 名接受腺样体扁桃体切除术的小于 18 岁的患者和 27 名对照组患者（小于 18 岁的入组患者的兄弟姐妹）。通过提示感染 COVID-19 的症状、COVID-19 检测和 SARS-CoV-2 特异性抗体测定分析了 COVID-19 的发病率：结果：在队列组中，COVID-19 阳性率为 80.5%（n = 29/36），有症状的 COVID-19 阳性率为 68.9%（n = 20/29）。在对照组中，COVID-19 阳性率为 44%（n = 12/27），无症状 COVID-19 阳性率为 16%（n = 2/12）。与对照组相比，队列中感染 COVID-19 的风险高出 1.8 倍，无症状 COVID-19 感染的相对风险为 4.14：这项试验性研究表明，腺样体扁桃体切除术使儿童感染 COVID-19 的风险明显升高，并可能导致其他病毒性上呼吸道感染。

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来源期刊

Indian Journal of Pediatrics 医学-小儿科

CiteScore

8.10

自引率

7.00%

发文量

394

审稿时长

3-6 weeks

期刊介绍： Indian Journal of Pediatrics (IJP), is an ofﬁcial publication of the Dr. K.C. Chaudhuri Foundation. The Journal, a peer-reviewed publication, is published twelve times a year on a monthly basis (January, February, March, April, May, June, July, August, September, October, November, December), and publishes clinical and basic research of all aspects of pediatrics, provided they have scientific merit and represent an important advance in knowledge. The Journal publishes original articles, review articles, case reports which provide new information, letters in relation to published articles, scientific research letters and picture of the month, announcements (meetings, courses, job advertisements); summary report of conferences and book reviews.