Nonlinear relationship between oxidative balance score and hyperuricemia: analyses of NHANES 2007-2018.

IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Nutrition Journal Pub Date : 2024-05-04 DOI:10.1186/s12937-024-00953-1
Fengmin Liu, Fangqin You, Lihang Yang, Xiaojuan Du, Cheng Li, Geng Chen, Diya Xie
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Abstract

Background: Limited data regarding the correlation between oxidative balance score (OBS) and hyperuricemia highlights the necessity for thorough investigations. This study aims to examine the link between OBS, which incorporates dietary and lifestyle factors, and the occurrence of hyperuricemia.

Methods: We conducted a cross-sectional study involving 13,636 participants from the 2007-2018 National Health and Nutrition Examination Survey (NHANES). The oxidative balance score (OBS) was determined based on four lifestyle factors and sixteen dietary nutrients. We assessed the levels of serum uric acid (SUA) and the occurrence of hyperuricemia as outcomes. Weighted logistic regression and linear models were used for statistical analysis, using Restricted Cubic Splines (RCS) to examine potential nonlinear associations. Subgroup analysis and sensitivity assessments were performed to identify any variations and ensure the robustness of the findings.

Results: Higher OBS was consistently correlated with decreased SUA levels and a reduced prevalence of hyperuricemia. RCS highlighted a significant negative nonlinear association, particularly in females. Subgroup analysis revealed gender-based differences and interactive correlation, providing additional insights regarding OBS and hyperuricemia relationship.

Conclusion: This study underscores a robust negative correlation between OBS and SUA levels as well as the incidence of hyperuricemia, emphasizing the importance of dietary and lifestyle factors. Incorporating RCS, subgroup analysis, and sensitivity assessments enhances the depth of our findings, providing valuable insights for further research.

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氧化平衡评分与高尿酸血症之间的非线性关系:2007-2018 年 NHANES 分析。
背景:有关氧化平衡评分(OBS)与高尿酸血症之间相关性的数据有限,因此有必要进行深入调查。本研究旨在探讨包含饮食和生活方式因素的 OBS 与高尿酸血症发生之间的联系:我们进行了一项横断面研究,涉及 2007-2018 年美国国家健康与营养调查(NHANES)的 13636 名参与者。根据四种生活方式因素和十六种膳食营养素确定了氧化平衡评分(OBS)。我们将血清尿酸(SUA)水平和高尿酸血症的发生率作为评估结果。我们使用加权逻辑回归和线性模型进行统计分析,并使用受限立方样条(RCS)检查潜在的非线性关联。还进行了亚组分析和敏感性评估,以确定任何变异并确保研究结果的稳健性:结果:较高的 OBS 与 SUA 水平的降低和高尿酸血症患病率的降低始终相关。RCS显示出明显的非线性负相关,尤其是女性。亚组分析显示了基于性别的差异和交互相关性,为了解 OBS 与高尿酸血症的关系提供了更多的信息:本研究强调了 OBS 与 SUA 水平以及高尿酸血症发病率之间的密切负相关关系,强调了饮食和生活方式因素的重要性。结合 RCS、亚组分析和敏感性评估增强了我们研究结果的深度,为进一步研究提供了宝贵的见解。
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来源期刊
Nutrition Journal
Nutrition Journal NUTRITION & DIETETICS-
CiteScore
9.80
自引率
0.00%
发文量
68
审稿时长
4-8 weeks
期刊介绍: Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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