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Correction: An unbiased, sustainable, evidence-informed Universal Food Guide: a timely template for national food guides. 更正:无偏见、可持续、有实证依据的《通用食品指南》:国家食品指南的及时模板。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-11-15 DOI: 10.1186/s12937-024-01043-y
Elizabeth Dean, Jia Xu, Alice Yee-Men Jones, Mantana Vongsirinavarat, Constantina Lomi, Pintu Kumar, Etienne Ngeh, Maximilian A Storz
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引用次数: 0
Body composition as a prognostic factor in cholangiocarcinoma: a meta-analysis. 身体成分是胆管癌的预后因素:一项荟萃分析。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-11-15 DOI: 10.1186/s12937-024-01037-w
Lilong Zhang, Kunpeng Wang, Rongqiang Liu, Tianrui Kuang, Chen Chen, Feng Yao, Weixing Wang

This investigation seeks to scrutinize the relationships between body composition metrics and the clinical outcomes observed in patients with cholangiocarcinoma (CCA). A comprehensive exploration was conducted across three prominent online databases: Embase, PubMed, and the Cochrane Library. This endeavor spanned the entirety of each database up to the cutoff date of September 29, 2023. To evaluate the quality of the included studies, the Newcastle-Ottawa scale was employed. This comprehensive analysis included a total of 26 articles with a combined patient cohort of 4398 individuals. The results demonstrated that CCA patients with low skeletal muscle index (SMI) had significantly inferior OS (HR: 1.93, p < 0.001) and RFS (HR: 2.02, p < 0.001), as well as a higher incidence of postoperative complications (OR: 1.69, 95% CI: 1.20-2.38, p < 0.001) compared to those with high SMI. The presence of sarcopenia in CCA patients was significantly related to poorer OS (HR: 1.96, p < 0.001) and RFS (HR: 2.05, p < 0.001), and a higher rate of postoperative complications (OR: 1.39, p = 0.049) in comparison to those without sarcopenia. Moreover, lower psoas muscle index (PMI) and myosteatosis were associated with shorter OS (PMI, HR: 1.56, p < 0.001; myosteatosis, HR: 1.49, p = 0.001) and RFS (PMI, HR: 2.16, p < 0.001; myosteatosis, HR: 1.35, p = 0.023). Our findings highlight incorporating body composition screening into clinical practice can help develop treatment strategies and optimize perioperative care, potentially improving patient outcomes.

这项调查旨在研究胆管癌(CCA)患者的身体成分指标与临床结果之间的关系。我们在三个著名的在线数据库中进行了全面探索:Embase、PubMed 和 Cochrane 图书馆。这项工作涵盖了截至 2023 年 9 月 29 日截止日期的所有数据库。为了评估所收录研究的质量,我们采用了纽卡斯尔-渥太华量表。这项综合分析共收录了 26 篇文章,患者群共计 4398 人。结果显示,骨骼肌指数(SMI)低的 CCA 患者的 OS 明显较差(HR:1.93,p
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引用次数: 0
Local food procurement behavior and overall diet quality among adults in Québec: results from the NutriQuébec project. 魁北克省成年人的本地食品采购行为和总体饮食质量:NutriQuébec 项目的结果。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-11-14 DOI: 10.1186/s12937-024-01045-w
Marianne Rochette, Gabrielle Rochefort, Catherine Laramée, Annie Lapointe, Simone Lemieux, Ariane Bélanger-Gravel, Sophie Desroches, Véronique Provencher, Benoît Lamarche

Background: Consumption of locally produced foods is generally perceived as being part of a healthy dietary pattern. Accordingly, in 2020, the provincial government of Québec (Canada) promoted the purchase of local foods for economic and health benefits. The present cross-sectional study aimed to document the association between the behavior of local food procurement and overall diet quality in a sample of adults from the province of Québec.

Methods: Data were collected in a sample of 834 adults (86.6% females) from the NutriQuébec project, a web-based longitudinal population study that aims to document the lifestyle and eating habits of adults in Québec, Canada. Dietary intakes were measured using a validated web-based 24-h recall tool and diet quality was assessed using the Healthy Eating Food Index (HEFI-2019), which measures adherence to the 2019-Canada's Food Guide recommendations on healthy food choices. Local food procurement behavior was measured using the Locavore-I-SF score, which assesses the frequency of short food supply chain use as well as the geographical origin of three locally produced foods.

Results: The Locavore-I-SF score was weakly correlated with the HEFI-2019 score (r = 0.08, p < 0.02). Positive correlations were observed for the Vegetables and fruits (r = 0.09, p = 0.005), Beverages (r = 0.08, p = 0.04) and Free sugars (r = 0.14, p < 0.001) components of the HEFI-2019. Associations between the Locavore-I-SF and the HEFI-2019 scores were found in specific subgroups of participants: males (r = 0.33, p < 0.001), participants aged between 50 and 70 years (r = 0.16, p = 0.003), participants with a greater education level (r = 0.13, p = 0.003) and higher income (r = 0.12, p = 0.02), non-vegetarian participants (r = 0.10, p = 0.008) and participants living in Census Metropolitan Areas (r = 0.11, p = 0.004).

Conclusion: These results suggest that the behavior of local food procurement is only weakly associated with better overall diet quality among a sample of adults from Québec, raising doubts on the relevance of promoting local food procurement as an effective public health measure for improving diet quality in Québec.

Study registration number: NCT04140071.

背景:人们普遍认为食用本地生产的食品是健康饮食模式的一部分。因此,魁北克(加拿大)省政府在 2020 年提倡购买本地食品,以获得经济和健康效益。本横断面研究旨在记录魁北克省成人样本中当地食品采购行为与整体饮食质量之间的关联:该项目是一项基于网络的纵向人口研究,旨在记录加拿大魁北克省成年人的生活方式和饮食习惯。膳食摄入量采用经过验证的基于网络的24小时回忆工具进行测量,膳食质量采用健康饮食食品指数(HEFI-2019)进行评估,该指数用于衡量《2019-加拿大食品指南》关于健康食品选择建议的遵守情况。本地食品采购行为采用Locavore-I-SF评分进行测量,该评分评估了短食品供应链的使用频率以及三种本地生产食品的地理来源:结果:Locavore-I-SF 分数与 HEFI-2019 分数呈弱相关(r = 0.08,p 结论:Locavore-I-SF 分数与 HEFI-2019 分数呈弱相关(r = 0.08,p 结论):这些结果表明,在魁北克省的一个成年人样本中,采购当地食品的行为与更好的总体饮食质量只有微弱的相关性,这使人们对促进当地食品采购作为改善魁北克省饮食质量的有效公共卫生措施的相关性产生了怀疑:NCT04140071。
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引用次数: 0
Consuming spicy food and type 2 diabetes incidence in Southwestern Chinese aged 30-79: a prospective cohort study. 食用辛辣食物与西南地区 30-79 岁中国人 2 型糖尿病发病率:一项前瞻性队列研究。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-11-11 DOI: 10.1186/s12937-024-00996-4
Liling Chen, Xiaomin Wu, Rui Zhang, Wenge Tang, Yuxuan Chen, Xianbin Ding, Jing Wu

Background: Capsaicin is the main component of chili peppers and is believed to have antidiabetic effects. However, the association between spicy food consumption and the incidence of diabetes remains unclear.

Methods: A cohort of 20,490 Han residents aged 30-79 without diabetes at baseline were followed from enrollment to June 2, 2023. The consumption of spicy food was obtained through face-to-face surveys conducted during the baseline survey from October 2018 to February 2019. The definition of type 2 diabetes onset was based on the ICD-10 code of E11 in the diabetes case reporting system and death system; Additionally, self-reported diagnosis of diabetes by a physician in active follow-ups, or a fasting blood glucose level of ≥ 7 mmol/L or a glycated hemoglobin percentage of ≥ 6.5% found on-site during the resurvey. Both Cox proportional hazard regression and competing risk regression were used to calculate hazard ratios (HRs) and confidence intervals (CIs).

Results: During the follow-up period (53.5 ± 3.0 months), 182 individuals (1.1%) were newly diagnosed with T2D with an incidence rate of 246.2 per 100,000 person-years. Cox regression analyses revealed that spicy food consumers had a 34% reduced risk of developing type 2 diabetes (HR: 0.66, 95% CI: 0.48, 0.91) compared to non-consumers. The HRs (95% CIs) for participants consuming spicy food 3-5 days/week, 6-7 days/week, and with weak pungency were 0.45 (95% CI: 0.25, 0.81), 0.69 (0.49, 0.98), and 0.64 (0.46, 0.90), respectively. However, little significant protective effect was observed among those who consumed spicy food for 1-2 days/week, with moderate pungency, or with strong pungency (all P > 0.05).

Conclusions: Consuming spicy food may lower the risk of developing type 2 diabetes, particularly at a frequency of 3-5 days/week, and with weak pungency. Further multicenter prospective studies or interventional studies are needed to confirm these findings.

背景:辣椒素是辣椒的主要成分,据信具有抗糖尿病作用。然而,食用辛辣食品与糖尿病发病率之间的关系仍不清楚:方法:对 20,490 名年龄在 30-79 岁之间、基线时未患有糖尿病的汉族居民进行了从入学到 2023 年 6 月 2 日的队列随访。在2018年10月至2019年2月的基线调查期间,通过面对面调查获得了辛辣食物的消费情况。2型糖尿病发病的定义基于糖尿病病例报告系统和死亡系统中的ICD-10代码E11;此外,在主动随访中由医生自我报告诊断为糖尿病,或在再次调查中现场发现空腹血糖水平≥7 mmol/L或糖化血红蛋白百分比≥6.5%。采用考克斯比例危害回归和竞争风险回归计算危害比(HR)和置信区间(CI):结果:在随访期间(53.5 ± 3.0 个月),有 182 人(1.1%)新诊断出患有 T2D,发病率为每 10 万人年 246.2 例。Cox回归分析显示,与不食用辛辣食品的人相比,食用辛辣食品的人患2型糖尿病的风险降低了34%(HR:0.66,95% CI:0.48,0.91)。每周食用辛辣食物 3-5 天、6-7 天和辛辣程度较弱的参与者的 HR 值(95% CI)分别为 0.45(95% CI:0.25,0.81)、0.69(0.49,0.98)和 0.64(0.46,0.90)。然而,在每周食用辛辣食物1-2天、辛辣程度适中或辛辣程度较强的人群中,几乎没有观察到明显的保护作用(所有P>0.05):结论:食用辛辣食物可降低罹患 2 型糖尿病的风险,尤其是每周食用 3-5 天且辛辣程度较弱的人群。需要进一步的多中心前瞻性研究或干预性研究来证实这些发现。
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引用次数: 0
Dietary amino acids intake and all-cause and cause-specific mortality: results from the Golestan Cohort Study. 膳食氨基酸摄入量与全因和特定原因死亡率:戈勒斯坦队列研究的结果。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-11-09 DOI: 10.1186/s12937-024-01044-x
Asieh Mansour, Sayed Mahmoud Sajjadi-Jazi, Maryam Mirahmad, Pooria Asili, Maryam Sharafkhah, Sahar Masoudi, Hossein Poustchi, Akram Pourshams, Maryam Hashemian, Azita Hekmatdoost, Reza Malekzadeh

Background: Less is known whether the amino acid composition of dietary protein sources effects on long-term health outcomes. We aimed to evaluate the association between dietary amino acid composition and all-cause and cause-specific mortality.

Methods: This study used data from the Golestan Cohort Study, which was performed in the Golestan Province of Iran from January 2004 to June 2008. Mortality, which was the primary outcome, was ascertained through September 2022. The Cox proportional hazards regression models were used to determine the adjusted hazard ratios (HR) and 95% confidence intervals (CI) for mortality according to the quintiles of amino acid consumption, taking the third quintile as the reference.

Results: A total of 47,337 participants (27,293 [57.7%] women) with a mean (standard deviation) age of 51.9 (8.9) years were included. During a median follow-up of 15 years, 9,231 deaths were documented. Regarding essential amino acid intakes, the HRs of all-cause mortality were 1.16 (95% CI, 1.07-1.26) in the first quintile, compared with the reference group (P for non-linear trend < 0.001). Similarly, non-linear associations were observed between risk of all-cause mortality and intake of branched-chain, aromatic, sulfur-containing, or non-essential amino acids (P for non-linear trend < 0.001 for all comparisons), with higher HRs for participants in the first quintiles. There was an age interaction for the associations between dietary amino acids and mortality (P for interaction ˂0.05). While high amino acid diets were detrimental in middle-aged adults (< 65 years), increased hazards of mortality were observed among older adults (≥ 65 years) with low amino acid intake.

Conclusions: This study showed the non-linear trend between amino acids intake and risk of mortality in the middle-aged and older Iranian population. Overall, our findings suggest that diets lower in amino acids were associated with increased hazards of mortality, particularly among older adults.

背景:人们对膳食蛋白质来源的氨基酸组成是否会影响长期健康结果知之甚少。我们旨在评估膳食氨基酸组成与全因死亡率和特定原因死亡率之间的关系:本研究使用了戈勒斯坦队列研究的数据,该研究于 2004 年 1 月至 2008 年 6 月在伊朗戈勒斯坦省进行。主要研究结果是截至 2022 年 9 月的死亡率。研究采用 Cox 比例危险回归模型,以第三五分位数为参考,根据氨基酸摄入量的五分位数确定死亡率的调整后危险比(HR)和 95% 置信区间(CI):共纳入 47,337 名参与者(27,293 名[57.7%]女性),平均(标准差)年龄为 51.9(8.9)岁。在中位数为 15 年的随访期间,共记录了 9,231 例死亡病例。在必需氨基酸摄入量方面,与参照组相比,第一五分位组的全因死亡率的 HR 值为 1.16(95% CI,1.07-1.26)(P 为非线性趋势结论):这项研究表明,在伊朗中老年人群中,氨基酸摄入量与死亡风险之间存在非线性趋势。总体而言,我们的研究结果表明,氨基酸含量较低的饮食与死亡率风险增加有关,尤其是在老年人中。
{"title":"Dietary amino acids intake and all-cause and cause-specific mortality: results from the Golestan Cohort Study.","authors":"Asieh Mansour, Sayed Mahmoud Sajjadi-Jazi, Maryam Mirahmad, Pooria Asili, Maryam Sharafkhah, Sahar Masoudi, Hossein Poustchi, Akram Pourshams, Maryam Hashemian, Azita Hekmatdoost, Reza Malekzadeh","doi":"10.1186/s12937-024-01044-x","DOIUrl":"10.1186/s12937-024-01044-x","url":null,"abstract":"<p><strong>Background: </strong>Less is known whether the amino acid composition of dietary protein sources effects on long-term health outcomes. We aimed to evaluate the association between dietary amino acid composition and all-cause and cause-specific mortality.</p><p><strong>Methods: </strong>This study used data from the Golestan Cohort Study, which was performed in the Golestan Province of Iran from January 2004 to June 2008. Mortality, which was the primary outcome, was ascertained through September 2022. The Cox proportional hazards regression models were used to determine the adjusted hazard ratios (HR) and 95% confidence intervals (CI) for mortality according to the quintiles of amino acid consumption, taking the third quintile as the reference.</p><p><strong>Results: </strong>A total of 47,337 participants (27,293 [57.7%] women) with a mean (standard deviation) age of 51.9 (8.9) years were included. During a median follow-up of 15 years, 9,231 deaths were documented. Regarding essential amino acid intakes, the HRs of all-cause mortality were 1.16 (95% CI, 1.07-1.26) in the first quintile, compared with the reference group (P for non-linear trend < 0.001). Similarly, non-linear associations were observed between risk of all-cause mortality and intake of branched-chain, aromatic, sulfur-containing, or non-essential amino acids (P for non-linear trend < 0.001 for all comparisons), with higher HRs for participants in the first quintiles. There was an age interaction for the associations between dietary amino acids and mortality (P for interaction ˂0.05). While high amino acid diets were detrimental in middle-aged adults (< 65 years), increased hazards of mortality were observed among older adults (≥ 65 years) with low amino acid intake.</p><p><strong>Conclusions: </strong>This study showed the non-linear trend between amino acids intake and risk of mortality in the middle-aged and older Iranian population. Overall, our findings suggest that diets lower in amino acids were associated with increased hazards of mortality, particularly among older adults.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"23 1","pages":"141"},"PeriodicalIF":4.4,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11549823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal iron nutrition during pregnancy and fetal intrauterine growth. 孕期母体铁营养与胎儿宫内发育。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-11-09 DOI: 10.1186/s12937-024-01042-z
Jiaomei Yang, Qianqian Chang, Qiancheng Du, Xin Liu, Shaonong Dang, Xueye Tian

Background: Iron is critical for maternal and fetal health; however, the effect of iron nutrition on fetal intrauterine growth remains unclear. This study aimed to investigate the associations of maternal iron nutrition during pregnancy with fetal intrauterine growth parameters among the Chinese population.

Methods: This retrospective birth cohort study included 482 pregnant women. Maternal information was collected by standard questionnaires. Maternal concentrations of serum ferritin and hemoglobin were detected. Fetal ultrasound examinations in the second and third trimesters were conducted. Quantile regression or linear regression models were applied to assess the associations.

Results: Participants took iron supplementation in early, mid, and late pregnancy accounted for 19.1%, 40.3%, and 37.8%, respectively. Iron supplementation in the first and second trimesters and total iron intake in pregnancy were positively associated with fetal intrauterine growth parameters at some percentiles. Compared with those without iron supplementation in the second trimester, women with iron supplementation in the second trimester had 0.37 (95%CI = 0.24-0.49), 0.37 (95%CI = 0.26-0.48), 0.15 (95%CI = 0.04-0.26), and 0.52 (95%CI = 0.42-0.61) higher z-scores in fetal biparietal diameter, femur length, abdominal circumference, and estimated fetal weight at the 50th percentile in the second trimester, respectively. Maternal serum ferritin and hemoglobin concentrations in the first and second trimesters were positively correlated with several fetal growth parameters.

Conclusions: Fetal intrauterine growth may benefit from maternal iron nutrition in the first and second trimesters.

背景:铁对母体和胎儿的健康至关重要,但铁营养对胎儿宫内生长的影响仍不清楚。本研究旨在调查中国孕妇孕期铁营养与胎儿宫内生长参数的关系:这项回顾性出生队列研究纳入了 482 名孕妇。方法:这项回顾性出生队列研究共纳入了 482 名孕妇,通过标准问卷收集了孕产妇信息。检测了孕妇血清铁蛋白和血红蛋白的浓度。在第二和第三个孕期进行了胎儿超声波检查。采用量子回归或线性回归模型评估相关性:结果:在孕早期、孕中期和孕晚期服用铁剂的孕妇分别占 19.1%、40.3% 和 37.8%。妊娠头三个月和后三个月的铁质补充量以及孕期铁质总摄入量与胎儿宫内生长参数的某些百分位数呈正相关。与后三个月未补充铁剂的孕妇相比,后三个月补充铁剂的孕妇的胎儿宫内生长参数分别为 0.37(95%CI = 0.24-0.49)、0.37(95%CI = 0.26-0.48)、0.15(95%CI = 0.在第二孕期,胎儿双顶径、股骨长、腹围和估计胎儿体重的 Z 值分别比第 50 百分位数高 0.15(95%CI = 0.04-0.26)、0.52(95%CI = 0.42-0.61)和 0.52(95%CI = 0.42-0.61)。妊娠头三个月和后三个月的母体血清铁蛋白和血红蛋白浓度与胎儿的几个生长参数呈正相关:胎儿宫内生长可能得益于妊娠头三个月和后三个月母体的铁营养。
{"title":"Maternal iron nutrition during pregnancy and fetal intrauterine growth.","authors":"Jiaomei Yang, Qianqian Chang, Qiancheng Du, Xin Liu, Shaonong Dang, Xueye Tian","doi":"10.1186/s12937-024-01042-z","DOIUrl":"10.1186/s12937-024-01042-z","url":null,"abstract":"<p><strong>Background: </strong>Iron is critical for maternal and fetal health; however, the effect of iron nutrition on fetal intrauterine growth remains unclear. This study aimed to investigate the associations of maternal iron nutrition during pregnancy with fetal intrauterine growth parameters among the Chinese population.</p><p><strong>Methods: </strong>This retrospective birth cohort study included 482 pregnant women. Maternal information was collected by standard questionnaires. Maternal concentrations of serum ferritin and hemoglobin were detected. Fetal ultrasound examinations in the second and third trimesters were conducted. Quantile regression or linear regression models were applied to assess the associations.</p><p><strong>Results: </strong>Participants took iron supplementation in early, mid, and late pregnancy accounted for 19.1%, 40.3%, and 37.8%, respectively. Iron supplementation in the first and second trimesters and total iron intake in pregnancy were positively associated with fetal intrauterine growth parameters at some percentiles. Compared with those without iron supplementation in the second trimester, women with iron supplementation in the second trimester had 0.37 (95%CI = 0.24-0.49), 0.37 (95%CI = 0.26-0.48), 0.15 (95%CI = 0.04-0.26), and 0.52 (95%CI = 0.42-0.61) higher z-scores in fetal biparietal diameter, femur length, abdominal circumference, and estimated fetal weight at the 50th percentile in the second trimester, respectively. Maternal serum ferritin and hemoglobin concentrations in the first and second trimesters were positively correlated with several fetal growth parameters.</p><p><strong>Conclusions: </strong>Fetal intrauterine growth may benefit from maternal iron nutrition in the first and second trimesters.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"23 1","pages":"140"},"PeriodicalIF":4.4,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11549782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between sulfur microbial diet and the risk of esophageal cancer: a prospective cohort study in 101,752 American adults. 含硫微生物饮食与食道癌风险之间的关系:对 101,752 名美国成年人进行的前瞻性队列研究。
IF 5.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-11-07 DOI: 10.1186/s12937-024-01035-y
Xiaorui Ren, Li Xin, Linglong Peng, Yi Xiao, Zhihang Zhou, Haoyun Luo, Zhiyong Zhu, Qi Wei, Yahui Jiang, Hongmei He, Ling Xiang, Yaxu Wang, Yunhao Tang, Haitao Gu

Background: Sulfur microbial diet (SMD) is a dietary pattern closely related to the intestinal load of sulfur-metabolizing microbes in humans. Diet and microbes may play an important role in the carcinogenesis of esophagus. However, epidemiological studies on SMD and esophageal cancer (EC) risk are scarce. Here, we evaluated this association based on a large American cohort.

Methods: In the cohort of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, a SMD score was calculated to evaluate participants' compliance of SMD pattern, with higher scores presenting greater adherence. Cox hazards regression model was used to explore the association between the SMD score and the incidence of EC, esophageal squamous cell carcinoma (ESCC), and esophageal adenocarcinoma (EA). Subgroup analyses were conducted to figure out potential modifiers interacting with SMD on EC. Sensitivity analyses were used to testify the robustness of our main result.

Results: Among 101,752 participants, 154 EC cases, consisted of 41 ESCC cases and 97 EA cases, were identified with mean follow-up of 8.9 years. In the fully adjusted model, the highest versus the lowest quartiles of the SMD score were found to be associated with an increased risk of EC and ESCC (EC: HRQ4 vs. Q1: 1.64; 95% CI: 1.05, 2.56; P = 0.016 for trend; ESCC: HRQ4 vs. Q1: 2.37; 95% CI: 1.02, 5.47; P = 0.031 for trend), while not significantly associated with increases risk of EA (HRQ4 vs. Q1: 1.41; P = 0.144 for trend). The main result remained through a series of sensitivity analyses. Subgroup analyses showed a stronger association between SMD and EC in participants with no regular consumption of aspirin (HRQ4 vs. Q1: 1.90; 95% CI: 1.04, 3.47) than in those using aspirin regularly (HRQ4 vs. Q1: 1.37; 95% CI: 0.71, 2.66) (P = 0.008 for interaction).

Conclusion: Adherence to the SMD pattern may be associated with increased risks of EC and ESCC, particularly for EC in individuals who do not regularly consume aspirin.

背景:硫微生物饮食(SMD)是一种与人类肠道硫代谢微生物负荷密切相关的饮食模式。饮食和微生物可能在食道癌的发生中扮演重要角色。然而,有关 SMD 和食管癌(EC)风险的流行病学研究却很少。在此,我们根据一个大型美国队列对这种关联进行了评估:方法:在前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验(PLCO)的队列中,计算了 SMD 分数,以评估参与者对 SMD 模式的依从性,分数越高,依从性越高。采用Cox危害回归模型探讨了SMD评分与EC、食管鳞状细胞癌(ESCC)和食管腺癌(EA)发病率之间的关系。研究人员还进行了亚组分析,以找出与SMD对EC的影响相互影响的潜在调节因素。敏感性分析用于检验我们主要结果的稳健性:在101752名参与者中,发现了154例EC病例,其中包括41例ESCC病例和97例EA病例,平均随访时间为8.9年。在完全调整模型中,发现SMD得分最高与最低四分位数与EC和ESCC风险增加有关(EC:HRQ4 vs. Q1:1.64;95% CI:1.05, 2.56;P = 0.016)。56; P = 0.016 for trend; ESCC: HRQ4 vs. Q1: 2.37; 95% CI: 1.02, 5.47; P = 0.031 for trend),而与 EA 风险增加无明显关联(HRQ4 vs. Q1: 1.41; P = 0.144 for trend)。通过一系列敏感性分析,主要结果依然存在。亚组分析显示,与定期服用阿司匹林的参与者(HRQ4 vs. Q1: 1.04, 3.47; 95% CI: 1.37; 95% CI: 0.71, 2.66)相比,未定期服用阿司匹林的参与者(HRQ4 vs. Q1: 1.90; 95% CI: 1.04, 3.47)的SMD与EC之间的关联性更强(P = 0.008表示交互作用):结论:SMD模式的坚持可能与EC和ESCC风险的增加有关,尤其是对于不经常服用阿司匹林的人来说。
{"title":"Association between sulfur microbial diet and the risk of esophageal cancer: a prospective cohort study in 101,752 American adults.","authors":"Xiaorui Ren, Li Xin, Linglong Peng, Yi Xiao, Zhihang Zhou, Haoyun Luo, Zhiyong Zhu, Qi Wei, Yahui Jiang, Hongmei He, Ling Xiang, Yaxu Wang, Yunhao Tang, Haitao Gu","doi":"10.1186/s12937-024-01035-y","DOIUrl":"10.1186/s12937-024-01035-y","url":null,"abstract":"<p><strong>Background: </strong>Sulfur microbial diet (SMD) is a dietary pattern closely related to the intestinal load of sulfur-metabolizing microbes in humans. Diet and microbes may play an important role in the carcinogenesis of esophagus. However, epidemiological studies on SMD and esophageal cancer (EC) risk are scarce. Here, we evaluated this association based on a large American cohort.</p><p><strong>Methods: </strong>In the cohort of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, a SMD score was calculated to evaluate participants' compliance of SMD pattern, with higher scores presenting greater adherence. Cox hazards regression model was used to explore the association between the SMD score and the incidence of EC, esophageal squamous cell carcinoma (ESCC), and esophageal adenocarcinoma (EA). Subgroup analyses were conducted to figure out potential modifiers interacting with SMD on EC. Sensitivity analyses were used to testify the robustness of our main result.</p><p><strong>Results: </strong>Among 101,752 participants, 154 EC cases, consisted of 41 ESCC cases and 97 EA cases, were identified with mean follow-up of 8.9 years. In the fully adjusted model, the highest versus the lowest quartiles of the SMD score were found to be associated with an increased risk of EC and ESCC (EC: HR<sub>Q4 vs. Q1</sub>: 1.64; 95% CI: 1.05, 2.56; P = 0.016 for trend; ESCC: HR<sub>Q4 vs. Q1</sub>: 2.37; 95% CI: 1.02, 5.47; P = 0.031 for trend), while not significantly associated with increases risk of EA (HR<sub>Q4 vs. Q1</sub>: 1.41; P = 0.144 for trend). The main result remained through a series of sensitivity analyses. Subgroup analyses showed a stronger association between SMD and EC in participants with no regular consumption of aspirin (HR<sub>Q4 vs. Q1</sub>: 1.90; 95% CI: 1.04, 3.47) than in those using aspirin regularly (HR<sub>Q4 vs. Q1</sub>: 1.37; 95% CI: 0.71, 2.66) (P = 0.008 for interaction).</p><p><strong>Conclusion: </strong>Adherence to the SMD pattern may be associated with increased risks of EC and ESCC, particularly for EC in individuals who do not regularly consume aspirin.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"23 1","pages":"139"},"PeriodicalIF":5.4,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations of sugary beverage intake with type 2 diabetes and the role of physical activity: a prospective cohort study. 含糖饮料摄入量与 2 型糖尿病的关系以及体育锻炼的作用:一项前瞻性队列研究。
IF 5.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-11-07 DOI: 10.1186/s12937-024-01006-3
Yihong Ding, Hui Chen, Jie Shen, Liyan Huang, Yaying Cao, Yan Zheng, Geng Zong, Changzheng Yuan

Background: Higher consumption of sugary beverages (SB) has been associated with type 2 diabetes (T2D), but whether these associations are modified by physical activity remains unclear. This study aimed to examine the associations of SB intake, including sugar-sweetened beverages (SSB), artificially sweetened beverages (ASB), and natural juices (NJ) with the risk of incident T2D, and the potential role of physical activity.

Methods: We included 153,862 diabetes-free participants in the UK Biobank who completed both the International Physical Activity Questionnaire at recruitment (2006-2010) and at least one 24-h dietary recall questionnaire in 2009-2012. We assessed the associations of each SB with the risk of incident T2D using Cox proportional hazard models, and explored the interactions between each SB and physical activity.

Results: During a median follow-up of 11.8 years, 6631 participants developed incident T2D. Participants consuming more SSB and ASB (comparing > 2 to 0 unit/d) had a higher hazard of T2D (hazard ratio [HR]: 1.17, 95% confidence interval [CI]: 1.05-1.31 for SSB; 1.54, 1.37-1.74 for ASB), while medium intake of NJ showed an inverse association (HR> 0-1 vs. 0 unit/d: 0.87, 95% CI: 0.82-0.92; HR> 1-2 vs. 0 unit/d: 0.88, 95% CI: 0.81-0.97) with incident T2D. No significant interactions between physical activity and SSB/ASB were found (P-interaction=0.204 for SSB, 0.926 for ASB), but the protective association of medium NJ intake with T2D was stronger among participants with higher level of physical activity (P-interaction = 0.043).

Conclusions: Higher intake of SSB and ASB was related to higher risks of T2D. Medium NJ intake was associated with a lower risk of T2D, particularly among individuals with higher physical activity level. These findings emphasized the importance of healthy beverage intake and adequate physical activity in diabetes prevention.

背景:较高的含糖饮料(SB)摄入量与 2 型糖尿病(T2D)有关,但这些关联是否会因体育锻炼而改变仍不清楚。本研究旨在探讨含糖饮料(包括含糖饮料(SSB)、人工增甜饮料(ASB)和天然果汁(NJ))摄入量与T2D发病风险的关系,以及体育锻炼的潜在作用:我们纳入了英国生物库中 153862 名无糖尿病的参与者,他们在招募时(2006-2010 年)完成了国际体育活动问卷调查,并在 2009-2012 年期间完成了至少一次 24 小时饮食回忆问卷调查。我们使用 Cox 比例危险模型评估了每种 SB 与 T2D 发病风险的相关性,并探讨了每种 SB 与体育锻炼之间的相互作用:结果:在中位 11.8 年的随访期间,有 6631 人罹患了 T2D。摄入更多 SSB 和 ASB 的参与者(将 > 2 单位/天与 0 单位/天进行比较)罹患 T2D 的风险更高(风险比 [HR]:1.17,95% 置信区间):1.17,95% 置信区间 [CI]:1.17,95% 置信区间 [CI]:1.05-1.31;1.54,1.37-1.74),而 NJ 的中等摄入量与此呈反向关系(HR>0-1 vs. 0 单位/天,0.87,95% 置信区间 [CI]:1.37-1.74):0.87, 95% CI: 0.82-0.92; HR> 1-2 vs. 0 unit/d:0.88,95% CI:0.81-0.97)。运动量与 SSB/ASB 之间没有发现明显的交互作用(P-交互作用=0.204(SSB),0.926(ASB)),但中等 NJ 摄入量与 T2D 的保护性关联在运动量较高的参与者中更强(P-交互作用=0.043):结论:固态饮料和非固态饮料摄入量越高,罹患终末期糖尿病的风险越高。中等NJ摄入量与较低的T2D风险有关,尤其是在体力活动水平较高的人群中。这些发现强调了健康饮料摄入量和充足的体育锻炼对预防糖尿病的重要性。
{"title":"Associations of sugary beverage intake with type 2 diabetes and the role of physical activity: a prospective cohort study.","authors":"Yihong Ding, Hui Chen, Jie Shen, Liyan Huang, Yaying Cao, Yan Zheng, Geng Zong, Changzheng Yuan","doi":"10.1186/s12937-024-01006-3","DOIUrl":"10.1186/s12937-024-01006-3","url":null,"abstract":"<p><strong>Background: </strong>Higher consumption of sugary beverages (SB) has been associated with type 2 diabetes (T2D), but whether these associations are modified by physical activity remains unclear. This study aimed to examine the associations of SB intake, including sugar-sweetened beverages (SSB), artificially sweetened beverages (ASB), and natural juices (NJ) with the risk of incident T2D, and the potential role of physical activity.</p><p><strong>Methods: </strong>We included 153,862 diabetes-free participants in the UK Biobank who completed both the International Physical Activity Questionnaire at recruitment (2006-2010) and at least one 24-h dietary recall questionnaire in 2009-2012. We assessed the associations of each SB with the risk of incident T2D using Cox proportional hazard models, and explored the interactions between each SB and physical activity.</p><p><strong>Results: </strong>During a median follow-up of 11.8 years, 6631 participants developed incident T2D. Participants consuming more SSB and ASB (comparing > 2 to 0 unit/d) had a higher hazard of T2D (hazard ratio [HR]: 1.17, 95% confidence interval [CI]: 1.05-1.31 for SSB; 1.54, 1.37-1.74 for ASB), while medium intake of NJ showed an inverse association (HR<sub>> 0-1 vs. 0 unit/d</sub>: 0.87, 95% CI: 0.82-0.92; HR<sub>> 1-2 vs. 0 unit/d</sub>: 0.88, 95% CI: 0.81-0.97) with incident T2D. No significant interactions between physical activity and SSB/ASB were found (P-interaction=0.204 for SSB, 0.926 for ASB), but the protective association of medium NJ intake with T2D was stronger among participants with higher level of physical activity (P-interaction = 0.043).</p><p><strong>Conclusions: </strong>Higher intake of SSB and ASB was related to higher risks of T2D. Medium NJ intake was associated with a lower risk of T2D, particularly among individuals with higher physical activity level. These findings emphasized the importance of healthy beverage intake and adequate physical activity in diabetes prevention.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"23 1","pages":"138"},"PeriodicalIF":5.4,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early intravenous branched-chain amino acid-enriched nutrition supplementation in older patients undergoing gastric surgery: a randomized clinical trial. 胃手术老年患者早期静脉补充支链氨基酸营养:随机临床试验。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-11-05 DOI: 10.1186/s12937-024-01041-0
Yimei Ma, Xining Zhao, Yan Pan, Yuying Yang, Ying Wang, Shengjin Ge

Background: The initiation time and formula for supplemental parenteral nutrition after surgery require optimization, especially in older patients undergoing major gastrointestinal surgery. This study aimed to assess the effect of early supplementation with a branched-chain amino acid (BCAA)-enriched formula (BAF) on short-term postoperative outcomes in older patients undergoing gastric surgery.

Methods: This single-center, prospective, double-blinded, randomized clinical trial was conducted from March 10, 2020, to September 15, 2022. Patients aged 65-80 years with gastric cancer scheduled for curative resection were assessed for eligibility and randomly allocated to a high-proportion BCAA (HBCAA) (early supplementation with the BAF) or control (routine nutrition) group. The primary outcome was the standardized length of hospital stay (LOS).

Results: A total of 150 patients were randomized. Thirteen patients were excluded due to the resection of other organs, presence of metastasis, or withdrawal of consent. Finally, we included 70 and 67 patients in the HBCAA and control groups, respectively (mean age: 70.5 ± 4.2 years; 96 men [70.1%]). The standardized LOS was significantly shorter in the treatment group than in the control group (median [interquartile range]: 8.0 [7.8, 8.0] vs. 8.5 [8.0, 9.0] days; mean difference, 0.38; 95% confidence interval [CI], 0.02-0.74 days; P < .001). Patients in the HBCAA group showed better gastrointestinal function with faster defecation (4.0 [3.6, 5.0] vs. 5.0 [4.0, 5.5] days; mean difference, 0.6 days; 95% CI, 0.26-0.94 days; P < .001) and semi-liquid diet initiation (8.0 [7.5, 8.0] vs. 8.0 [8.0, 8.8] days; mean difference, 0.36 days; 95% CI, 0.03-0.7 days; P < .001) and had lesser weight loss at postoperative day 5 than those in the control group did (3.5 [2.7, 6.5] vs. 4.9 [3.3, 7.6]%; mean difference, 1.23%; 95% CI, 0.27-2.19%; P = .011).

Conclusions: In this randomized clinical trial, compared with routine nutrition, early supplementation with a BAF was associated with a shorter standardized LOS in older patients undergoing gastric surgery, suggesting that it may be a favorable strategy for patients with a poor tolerance to external nutrition who are undergoing major surgery.

Trial registration: ClinicalTrials.gov; Identifier: ChiCTR2000029635.

背景:术后补充肠外营养的开始时间和配方需要优化,尤其是对于接受大型胃肠道手术的老年患者。本研究旨在评估早期补充富含支链氨基酸(BCAA)的配方(BAF)对接受胃部手术的老年患者术后短期预后的影响:这项单中心、前瞻性、双盲、随机临床试验于 2020 年 3 月 10 日至 2022 年 9 月 15 日进行。年龄在 65-80 岁之间、计划接受根治性切除术的胃癌患者接受资格评估,并随机分配到高比例 BCAA (HBCAA) 组(早期补充 BAF)或对照组(常规营养)。主要结果是标准化住院时间(LOS):共有 150 名患者接受了随机治疗。13名患者因切除其他器官、出现转移或撤回同意书而被排除在外。最后,我们将 70 名和 67 名患者分别纳入 HBCAA 组和对照组(平均年龄:70.5 ± 4.2 岁;96 名男性 [70.1%])。治疗组的标准化住院日明显短于对照组(中位数[四分位数间距]:8.0 [7.8, 8.0] 天 vs. 8.5 [8.0, 9.0] 天;平均差异:0.38;95% 置信区间[CI]:0.02-0.74 天;P 结论:治疗组的标准化住院日明显短于对照组:在这项随机临床试验中,与常规营养相比,在接受胃部手术的老年患者中,早期补充BAF与缩短标准化住院日有关,这表明对于外部营养耐受性差且接受大手术的患者来说,BAF可能是一种有利的策略:试验注册:ClinicalTrials.gov;Identifier:试验注册:ClinicalTrials.gov;标识符:ChiCTR2000029635。
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引用次数: 0
Sensory processing and child appetitive traits: findings from the ROLO longitudinal birth cohort study. 感官处理与儿童食欲特征:ROLO 出生队列纵向研究的发现。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-11-01 DOI: 10.1186/s12937-024-01040-1
Anna Delahunt, Sophie Callanan, Eileen C O' Brien, Aisling A Geraghty, Sharleen L O' Reilly, Ciara M McDonnell, Emma Hokey, Fionnuala M McAuliffe

Background: Oral sensory hypersensitivity has been linked with fussy eating predominantly in non-typically developing children. We hypothesized that child 'Oral' (touch, smell and taste in the mouth) and 'Social-Emotional' (response to social expectations) sensory processing are associated with child appetitive traits in typically developing preteen children. Additionally, we explored relationships between maternal sensory profiles and their offspring's sensory profile.

Methods: This is secondary analysis of 130 mother-child dyads from the 9-11-year-old follow-up of the ROLO longitudinal birth cohort study. The Dunn Sensory Profile (Adolescent/Adult) and the Dunn Child Sensory Profile 2 were used to assess maternal and child sensory profiles, respectively. The Children's Eating Behaviour Questionnaire was used to assess child appetitive traits. Multiple linear regression examined associations between 'Oral' and 'Social-Emotional' segments of the child sensory profile and child appetitive traits. Associations between maternal and child sensory profiles were examined using sensory profile quadrants (Dunn's sensory processing framework). These refer to four distinct patterns of sensory processing that indicate how an individual responds to sensory input.

Results: In total, 130 mother-child dyads were included. In adjusted analysis child 'Oral' sensory processing was associated with higher mean scores in the appetitive traits 'Desire to Drink' (B = 0.044, 95% CI = 0.025,0.062) and 'Food Fussiness' (B = 0.080, 95% CI = 0.059,0.101) and with lower mean scores in 'Enjoyment of Food' (B=-0.038, 95% CI -0.055,-0.022). Child 'Social-Emotional' responses were associated with higher mean scores in 'Desire to Drink' and 'Food Fussiness'. Higher scores in the maternal sensory profile quadrants of 'Sensitivity', 'Avoiding' and 'Registration' were positively associated with higher scores in the corresponding child sensory profile quadrants.

Conclusion: Our findings suggest that in typically developing children presenting with fussy eating, oral sensory hypersensitivity and higher scores in social-emotional responses to sensory processing may be an underlying determinant. The relationship observed between 'Oral' and 'Social-Emotional' sensory processing segments and 'Desire to Drink' requires further research to ascertain the type of drinks being consumed and how this impacts appetite. Further research is also required to explore the influence of maternal sensory profile on their offsprings response to sensory input.

背景:口腔感觉过敏主要与非典型发育儿童挑食有关。我们假设儿童的 "口腔"(口腔中的触觉、嗅觉和味觉)和 "社会-情感"(对社会期望的反应)感觉处理与发育典型的青春期前儿童的食欲特征有关。此外,我们还探讨了母亲感官特征与后代感官特征之间的关系:这是对 ROLO 纵向出生队列研究 9-11 岁随访的 130 个母子二人组进行的二次分析。邓恩感官档案(青少年/成人)和邓恩儿童感官档案 2 分别用于评估母亲和儿童的感官档案。儿童饮食行为问卷用于评估儿童的食欲特征。多元线性回归研究了儿童感官特征中 "口腔 "和 "社会-情感 "部分与儿童食欲特征之间的关联。使用感官特征象限(邓恩感官加工框架)研究了母婴感官特征之间的关联。这指的是四种不同的感觉处理模式,它们表明了个体对感觉输入的反应:共有 130 个母子二人组被纳入研究。在调整分析中,儿童 "口腔 "感觉处理与食欲特征 "想喝水"(B = 0.044,95% CI = 0.025,0.062)和 "食物烦躁"(B = 0.080,95% CI = 0.059,0.101)的平均得分较高相关,而与 "享受食物"(B =-0.038,95% CI -0.055,-0.022)的平均得分较低相关。儿童的 "社会情感 "反应与 "想喝水 "和 "食物烦躁 "的平均得分较高有关。母亲感官特征中 "敏感"、"回避 "和 "登记 "象限的较高得分与相应儿童感官特征象限的较高得分呈正相关:我们的研究结果表明,对于发育典型的挑食儿童来说,口腔感觉过敏和对感觉处理的社会情感反应得分较高可能是一个潜在的决定因素。观察到的 "口腔 "和 "社会-情感 "感官处理部分与 "喝饮料的欲望 "之间的关系需要进一步研究,以确定所喝饮料的类型以及这对食欲的影响。此外,还需要进一步研究母亲的感官特征对其子女感官输入反应的影响。
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引用次数: 0
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Nutrition Journal
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