Bio-efficacy of Olyset® Plus, PermaNet® 3.0 and Interceptor® G2 on pyrethroid-resistant populations of Anopheles gambiae s.l. prior to the June 2023 net distribution campaign in Benin, West Africa.

IF 3.6 Q1 TROPICAL MEDICINE Tropical Medicine and Health Pub Date : 2024-04-30 DOI:10.1186/s41182-024-00599-z
David Mahouton Zoungbédji, Germain Gil Padonou, Arthur Sovi, Alphonse Keller Konkon, Albert Sourou Salako, Roseric Azondékon, Aboubakar Sidick, Juvénal Minassou Ahouandjinou, Linda Towakinou, Razaki Ossè, Rock Aïkpon, Cyriaque Affoukou, Lamine Baba-Moussa, Martin Akogbéto
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Abstract

Background: This study investigates the effectiveness of new-generation mosquito nets, like Olyset® Plus and PermaNet® 3.0, and dual-action nets such as Interceptor® G2, against pyrethroid-resistant Anopheles gambiae mosquitoes following the 2023 mass distribution of long-lasting insecticidal nets in Benin.

Methods: We tested wild mosquito populations from six communes in Benin against various pyrethroid (permethrin 0.75%, alphacypermethrin 0.05%, and deltamethrin 0.05%) using WHO tube tests. Additionally, we exposed mosquitoes to chlorfenapyr 100 µg/ml using the CDC bottle bioassay method. A subset of mosquitoes underwent biochemical and PCR tests to check the overexpression of metabolic enzymes and the Kdr L1014F mutation. We evaluated the effectiveness of Olyset® Plus, PermaNet® 3.0, and Interceptor® G2 nets using cone and tunnel tests on both laboratory and field populations of An. gambiae.

Results: Overall, the highest mortality rate was 60% with pyrethroid and 98 to100% with chlorfenapyr. In cone tests, all three types of nets induced mortality rates above 80% in the susceptible laboratory strain of An. gambiae. Notably, Olyset® Plus showed the highest mortality rates for pyrethroid-resistant mosquitoes in cone tests, ranging from 81.03% (95% CI: 68.59-90.13) in Djougou to 96.08% (95% CI: 86.54-99.52) in Akpro-Missérété. PermaNet® 3.0 had variable rates, from 42.5% (95% CI: 27.04-59.11) in Djougou to 58.54% (95% CI: 42.11-73.68) in Porto-Novo. However, revealed good results for Interceptor® G2, with 94% (95% CI: 87.40-97.77) mortality and 89.09% blood sampling inhibition in local populations of An. gambiae. In comparison, Interceptor® had lower rates of 17% (95% CI: 10.23-25.82) and 60%, respectively.

Conclusion: These results suggest that tunnel tests are effective for evaluating dual-active ingredient nets. Additionally, Interceptor® G2 and PBO nets like Olyset® Plus could be considered as alternatives against pyrethroid-resistant mosquitoes.

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2023 年 6 月在西非贝宁开展撒网行动之前,Olyset® Plus、PermaNet® 3.0 和 Interceptor® G2 对抗除虫菊酯的冈比亚按蚊种群的生物功效。
背景:本研究调查了新一代蚊帐(如 Olyset® Plus 和 PermaNet® 3.0)以及双效蚊帐(如 Interceptor® G2)在贝宁 2023 年大规模分发长效驱蚊蚊帐后对抗拟除虫菊酯的冈比亚按蚊的有效性:我们使用世界卫生组织的试管测试法,对贝宁六个社区的野生蚊子种群进行了针对各种拟除虫菊酯(0.75% 氯菊酯、0.05% 阿尔法氯菊酯和 0.05%溴氰菊酯)的测试。此外,我们还采用疾病预防控制中心的瓶式生物测定法,让蚊子接触 100 µg/ml 氯虫苯甲酰胺。一部分蚊子接受了生化和 PCR 检测,以检查代谢酶的过度表达和 Kdr L1014F 突变。我们使用锥形和隧道测试评估了 Olyset® Plus、PermaNet® 3.0 和 Interceptor® G2 蚊帐对实验室和野外冈比亚疟蚊种群的效果:总体而言,拟除虫菊酯的最高死亡率为 60%,氯虫苯甲酰胺的死亡率为 98% 至 100%。在锥形试验中,所有三种蚊帐对易感的实验室冈比亚蚂蚁菌株的致死率都超过了 80%。值得注意的是,在锥形试验中,Olyset® Plus 对抗除虫菊酯蚊子的死亡率最高,在 Djougou 为 81.03%(95% CI:68.59-90.13),在 Akpro-Missérété 为 96.08%(95% CI:86.54-99.52)。PermaNet® 3.0 的使用率从 Djougou 的 42.5%(95% CI:27.04-59.11)到 Porto-Novo 的 58.54%(95% CI:42.11-73.68)不等。然而,Interceptor® G2的效果很好,在当地的冈比亚蚂蚁种群中,死亡率为94%(95% CI:87.40-97.77),血液采样抑制率为89.09%。相比之下,Interceptor® 的死亡率较低,分别为 17%(95% CI:10.23-25.82)和 60%:这些结果表明,隧道测试可有效评估双效成分蚊帐。此外,Interceptor® G2 和 PBO 蚊帐(如 Olyset® Plus)可考虑作为替代品,以对付耐除虫菊酯的蚊子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Tropical Medicine and Health
Tropical Medicine and Health TROPICAL MEDICINE-
CiteScore
7.00
自引率
2.20%
发文量
90
审稿时长
11 weeks
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