A comprehensive review on the recent advances for 5-aminolevulinic acid production by the engineered bacteria.

IF 8.1 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Critical Reviews in Biotechnology Pub Date : 2024-05-05 DOI:10.1080/07388551.2024.2336532
Ying-Ying Chen, Jia-Cong Huang, Cai-Yun Wu, Shi-Qin Yu, Yue-Tong Wang, Chao Ye, Tian-Qiong Shi, He Huang
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Abstract

5-Aminolevulinic acid (5-ALA) is a non-proteinogenic amino acid essential for synthesizing tetrapyrrole compounds, including heme, chlorophyll, cytochrome, and vitamin B12. As a plant growth regulator, 5-ALA is extensively used in agriculture to enhance crop yield and quality. The complexity and low yield of chemical synthesis methods have led to significant interest in the microbial synthesis of 5-ALA. Advanced strategies, including the: enhancement of precursor and cofactor supply, compartmentalization of key enzymes, product transporters engineering, by-product formation reduction, and biosensor-based dynamic regulation, have been implemented in bacteria for 5-ALA production, significantly advancing its industrialization. This article offers a comprehensive review of recent developments in 5-ALA production using engineered bacteria and presents new insights to propel the field forward.

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全面回顾工程菌生产 5-氨基乙酰丙酸的最新进展。
5- 氨基乙酰丙酸(5-ALA)是合成四吡咯化合物(包括血红素、叶绿素、细胞色素和维生素 B12)所必需的一种非蛋白源氨基酸。作为一种植物生长调节剂,5-ALA 被广泛用于农业,以提高作物产量和质量。由于化学合成方法的复杂性和低产量,人们对 5-ALA 的微生物合成产生了浓厚的兴趣。先进的策略包括:加强前体和辅助因子的供应、关键酶的区隔、产物转运体工程、减少副产物的形成以及基于生物传感器的动态调控,这些策略已在细菌中用于 5-ALA 的生产,极大地推动了其工业化进程。本文全面回顾了利用工程菌生产 5-ALA 的最新进展,并提出了推动该领域发展的新见解。
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来源期刊
Critical Reviews in Biotechnology
Critical Reviews in Biotechnology 工程技术-生物工程与应用微生物
CiteScore
20.80
自引率
1.10%
发文量
71
审稿时长
4.8 months
期刊介绍: Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.
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