Evaluation of Choroidal Thickness and Choroidal Vascularity Index in Patients with Rheumatoid Arthritis.

IF 2.6 4区医学 Q2 OPHTHALMOLOGY Ocular Immunology and Inflammation Pub Date : 2025-01-01 Epub Date: 2024-05-01 DOI:10.1080/09273948.2024.2345289

Gülce Gökgöz Özışık, Dilek Eker Buyuksireci, Tayfun Şahin, Ayla Caglıyan Turk

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Abstract

Purpose: To evaluate the choroidal vascularity index and choroidal thickness in patients with rheumatoid arthritis.

Method: This study is a case control study. Our study consists of a total of two groups, with 32 individuals diagnosed with rheumatoid arthritis (RA) and 32 healthy volunteers. The thickness of the subfoveal choroid was measured from the 500 micron (µm), 1000 µm, 1500 µm nasal aspect of the fovea, and 500µm, 1000µm, 1500 µm temporal and subfoveal thickness of the fovea. ImageJ version 1.53i (National Institutes of Health, Bethesda, MD, USA) from open access was used for choroidal vascular index calculation.

Results: The mean age (p = 0.064) and gender distribution (p = 0.522) were not statistically different between these two groups. There was no difference between the groups in terms of visual acuity (p = 0.060), intraocular pressures (p=0.056), refractive errors (p = 0.418), and axial lengths (p = 0.280). Temporal 500 µm CT (p = 0.038), temporal 1000 µm CT (p = 0.010), and temporal 1500 µm CT (p = 0.005) differed significantly between the groups. The luminal area was significantly different between the RA group (842.71 ± 192.77) and the control group (957.78 ± 230.83) (p = 0.034). The choroidal vascularity index showed a significant difference between the RA group (64.99 ± 4.71) and the control group (67.34 ± 3.40) (p = 0.026). A significant difference was observed between the seronegative RA and the control group with temporal 1500 µm CT (p = 0.030), temporal 1000 µm CT (p = 0.023), and luminal area (p = 0.034).

Conclusion: We demonstrated thinning in CT and decreased CVI for the first time in RA patients by comparing it with the control group.

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评估类风湿性关节炎患者的脉络膜厚度和脉络膜血管指数

目的：评估类风湿性关节炎患者的脉络膜血管指数和脉络膜厚度：本研究为病例对照研究。我们的研究共分为两组，一组是 32 名确诊为类风湿性关节炎（RA）的患者，另一组是 32 名健康志愿者。眼窝下脉络膜的厚度分别从眼窝鼻侧的 500 微米、1000 微米和 1500 微米，以及眼窝颞侧和眼窝下的 500 微米、1000 微米和 1500 微米进行测量。计算脉络膜血管指数时使用了开放获取的 ImageJ 1.53i 版（美国马里兰州贝塞斯达国立卫生研究院）：结果：两组患者的平均年龄（p = 0.064）和性别分布（p = 0.522）无统计学差异。两组在视力（p = 0.060）、眼压（p=0.056）、屈光不正（p = 0.418）和轴向长度（p = 0.280）方面没有差异。颞部 500 µm CT（p = 0.038）、颞部 1000 µm CT（p = 0.010）和颞部 1500 µm CT（p = 0.005）在各组之间存在显著差异。RA 组（842.71 ± 192.77）和对照组（957.78 ± 230.83）的管腔面积有明显差异（p = 0.034）。脉络膜血管指数在 RA 组（64.99 ± 4.71）和对照组（67.34 ± 3.40）之间存在显著差异（P = 0.026）。血清阴性 RA 组与对照组在颞部 1500 µm CT（p = 0.030）、颞部 1000 µm CT（p = 0.023）和管腔面积（p = 0.034）方面存在明显差异：结论：通过与对照组进行比较，我们首次发现 RA 患者的 CT 变薄，CVI 减少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.