Diagnostic Accuracy of Conjunctival Rt-Pcr in Sars-Cov-2: A Systematic Review and Diagnostic Accuracy Meta-Analysis.

IF 2.6 4区医学 Q2 OPHTHALMOLOGY Ocular Immunology and Inflammation Pub Date : 2024-10-01 Epub Date: 2024-04-30 DOI:10.1080/09273948.2023.2272200

Aurélie Faubert, Rania Bohsina, Eunice You, Mélanie Hébert, May Griffith, Marie-Josée Aubin

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引用次数: 0

Abstract

Purpose: To study the positivity rate of conjunctival realtime polymerase chain reaction (RT-PCR) testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Design: Systematic review and diagnostic accuracy meta-analysis.

Methods: MEDLINE and EMBASE were queried using medical subject headings terms. Diagnostic accuracy meta-analyses and forest plots were obtained using the RevMan software.

Results: After deduplication, appraisal of abstract titles and full-text analysis of 1441 articles, 42 articles with 3351 COVID-19 patients were included in this review. Of these, 412 conjunctival swabs/Schirmer paper strips tested positive for SARS-CoV-2 by RT-PCR. The pooled sensitivity of the RT-PCR tests across the 24 studies with laboratory-confirmed COVID-19 patients was 10.3%.

Conclusions: Only 1 in 10 RT-PCR tests performed on conjunctival swabs were positive for SARS-CoV-2. Although this suggests that SARS-CoV-2 is likely present and detectable in the conjunctiva, this detection method has low diagnostic potential.

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结膜 Rt-Pcr 在 Sars-Cov-2 中的诊断准确性：系统综述和诊断准确性元分析。

目的：研究结膜实时聚合酶链反应（RT-PCR）检测严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）的阳性率：设计：系统综述和诊断准确性荟萃分析：方法：使用医学主题词检索 MEDLINE 和 EMBASE。使用RevMan软件进行诊断准确性荟萃分析和森林图分析：结果：在对1441篇文章进行重复数据删除、摘要标题评估和全文分析后，本综述共纳入42篇文章，涉及3351名COVID-19患者。其中，412 份结膜拭子/Schirmer 纸条通过 RT-PCR 检测出 SARS-CoV-2 阳性。在实验室确诊的 24 项 COVID-19 患者研究中，RT-PCR 检测的总灵敏度为 10.3%：结论：对结膜拭子进行的每 10 次 RT-PCR 检测中，只有 1 次对 SARS-CoV-2 呈阳性。尽管这表明结膜中可能存在并可检测到 SARS-CoV-2，但这种检测方法的诊断潜力较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.