Unveiling Key Pathological Indicators for Disease Progression in Vogt Koyanagi Harada Disease and Sympathetic Ophthalmia Through Advanced Choroidal Volume Analysis.

IF 2.6 4区 医学 Q2 OPHTHALMOLOGY Ocular Immunology and Inflammation Pub Date : 2024-11-01 Epub Date: 2024-05-06 DOI:10.1080/09273948.2024.2337836
Akira Tanikawa, Kazuichi Maruyama, Shiyi Liu, Zaixing Mao, Zhenguo Wang, Nobuhiko Shiraki, Noriyasu Hashida, Ryo Kawasaki, Kinpui Chan, Kohji Nishida
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Abstract

Purpose: To evaluate the association between quantitative parameters derived from volume analysis of optical coherence tomography (OCT) data and disease worsening in Vogt-Koyanagi-Harada disease (VKHD) and sympathetic ophthalmia (SO).

Methods: This retrospective study, conducted at Osaka University Hospital, employed swept-source OCT scans from patients diagnosed with VKHD or SO between October 2012 and January 2021. The choroidal vessel structure was segmented and visualized in three dimensions, generating quantitative vessel volume maps. Region-specific choroidal vessel volume (CVV), choroidal volume (CV), and vessel index (VI) were scrutinized for their potential correlation with disease severity.

Results: Thirty-five eyes of 18 VKHD and 2 SO patient (8 females, 10 males) were evaluated. OCT-derived CVV maps revealed regional CV alterations in VKHD and SO patients. Two parameters, i.e. CV at 3- and 6-month follow-ups (p = 0.044, p = 0.040, respectively, with area under the ROC curve of 0.70) and CVV at 6 months (p = 0.046, area under the ROC curve of 0.71), were significantly higher in recurrent VKHD and SO compared to effectively treated cases.

Conclusions: The volume analysis of OCT images facilitates a three-dimensional visualization of choroidal alterations, which may serve as a reflection of disease severity in VKHD and SO patients. Furthermore, noninvasive initial CVV or CV measurements may serve as potential biomarkers for predicting disease recurrence in VKHD and SO.

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通过高级脉络膜体积分析揭示 Vogt Koyanagi Harada 病和交感神经性眼炎疾病进展的关键病理指标。
目的:评估光学相干断层扫描(OCT)数据体积分析得出的定量参数与Vogt-Koyanagi-Harada病(VKHD)和交感神经性眼炎(SO)疾病恶化之间的关联:这项回顾性研究在大阪大学医院进行,采用了2012年10月至2021年1月期间被诊断为VKHD或SO患者的扫源OCT扫描数据。对脉络膜血管结构进行了三维分割和可视化,生成了定量血管体积图。对特定区域的脉络膜血管体积(CVV)、脉络膜体积(CV)和血管指数(VI)进行了仔细检查,以确定它们与疾病严重程度的潜在相关性:对 18 名 VKHD 和 2 名 SO 患者(8 名女性,10 名男性)的 35 只眼睛进行了评估。OCT 导出的 CVV 图显示了 VKHD 和 SO 患者的区域性 CV 改变。两个参数,即 3 个月和 6 个月随访时的 CV(分别为 p = 0.044 和 p = 0.040,ROC 曲线下面积为 0.70)和 6 个月时的 CVV(p = 0.046,ROC 曲线下面积为 0.71),在复发性 VKHD 和 SO 患者中明显高于有效治疗病例:OCT图像的容积分析有助于脉络膜改变的三维可视化,可反映VKHD和SO患者的疾病严重程度。此外,无创初始CVV或CV测量值可作为预测VKHD和SO疾病复发的潜在生物标志物。
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来源期刊
CiteScore
6.20
自引率
15.20%
发文量
285
审稿时长
6-12 weeks
期刊介绍: Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.
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