Biliary atresia in children (analytical literature review and review of own observation).

Q4 Medicine Wiadomosci lekarskie Pub Date : 2024-01-01 DOI:10.36740/WLek202403129

Olga Gorbatyuk, Halyna Kurylo

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Abstract

Objective: Aim: to review information resources and analysis of the own experience on this problem for the provision of modern knowledge in the pathogenesis of the pathology, the latest diagnostic and treatment technologies, with consideration of the need to adhere to a single strategy in the management of patients with BA.

Patients and methods: Materials and Methods: The analysis of the data regarding the results of existing studies evaluating the clinical benefit and safety of diagnostic and treatment methods in Biliary atresia.

Conclusion: Conclusions: BA is the leading cause of neonatal cholestasis development. Early diagnostics of BA, based on the complex evaluation of clinical-laboratory, instrumental and morphological signs of the pathology, has a significant meaning. Surgical correction during the first 2 months of life - the Kasai procedure, as well as dynamic post-surgery follow-up significantly prolong the life of children and allow postponing liver transplantation. The highest patient survival both at the first stage of treatment - conduction of the Kasai procedure and the stage of liver transplantation may be achieved by joined work of surgeons and pediatricians, which allows considering the whole row of possible problems.

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儿童胆道闭锁（分析性文献回顾和自身观察回顾）。

目标目的：回顾信息资源，分析自身在这一问题上的经验，以提供病理发病机制方面的现代知识、最新诊断和治疗技术，同时考虑到在管理 BA 患者时需要坚持单一策略：材料与方法：分析有关现有研究结果的数据，评估胆道闭锁诊断和治疗方法的临床益处和安全性：结论：结论：胆道闭锁是新生儿胆汁淤积症发病的主要原因。根据临床实验室、仪器和病理形态学迹象的综合评估，早期诊断胆道闭锁具有重要意义。出生后 2 个月内的手术矫正--卡萨伊手术，以及手术后的动态随访能显著延长患儿的生命，并推迟肝脏移植手术。通过外科医生和儿科医生的共同努力，无论是在治疗的第一阶段--卡萨伊手术的实施阶段，还是在肝脏移植阶段，都可以实现最高的患者存活率，从而考虑到所有可能出现的问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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