Mumps vaccination and immune status among Japanese university students: A multicenter cross-sectional study.

IF 1.6 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Journal of Public Health Research Pub Date : 2024-05-01 eCollection Date: 2024-04-01 DOI:10.1177/22799036241246702
Jiro Takeuchi, Iwata Ozaki, Kokichi Hata, Manami Nozawa, Kanami Fukushima, Norio Fukumori, Mie Imanaka, Yuta Sakanishi, Masayuki Shima, Takeshi Morimoto
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Abstract

Background: During the mumps outbreak in Japan in 2016, 159,031 cases were reported. In a survey conducted in 2015, mumps vaccination rates for the first dose were 30%-40%. However, the rates for two or more doses were not determined. We assessed the mumps vaccination rates and mumps infection prevalence according to vaccine doses received.

Design and methods: This was a multicenter cross-sectional study. Students from three universities participated in 2019. Informed consent was obtained from the students and their guardians. The primary outcome was the prevalence of breakthrough mumps infection according to the number of doses of vaccine received. We collected data on past illnesses of vaccine-preventable diseases and vaccination history using a questionnaire, photocopies of the Maternal and Child Health Handbook from the guardians, and virus antibody titers from the universities' health centers.

Results: This study assessed 2004 eligible students and included 593 (29.6%); of these, 250 (42.7%) had a mumps infection history. Furthermore, 264 (44.6%), 31 (5.2%), and 2 (0.3%) students received the first, second, and third doses of mumps vaccine, respectively. The mumps seropositivity prevalence was 43.2% (n = 127), 36.7% (n = 97), 26.7% (n = 8), and 100% (n = 2) for the no-, first-, second-, and third-dose groups, respectively (p for trend = 0.09). The mumps infection prevalence rates were 69.8% (n = 203), 11.3% (n = 28), 3.9% (n = 1), and 0% for the no-, first-, second-, and third-dose groups, respectively.

Conclusions: Approximately 1 in 10 students who had received only one dose of mumps-containing vaccine had a breakthrough infection history.

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日本大学生的腮腺炎疫苗接种和免疫状况:一项多中心横断面研究
背景:2016 年日本流行性腮腺炎爆发期间,共报告了 159031 例病例。在 2015 年进行的一项调查中,第一剂腮腺炎疫苗的接种率为 30%-40%。但是,两剂或更多剂的接种率尚未确定。我们根据接种疫苗的剂量评估了腮腺炎疫苗接种率和腮腺炎感染率:这是一项多中心横断面研究。来自三所大学的学生参加了2019年的研究。研究获得了学生及其监护人的知情同意。主要结果是根据接种疫苗的剂量计算突破性腮腺炎感染率。我们通过问卷调查、监护人提供的《母子健康手册》复印件以及大学卫生中心提供的病毒抗体滴度,收集了有关既往患疫苗可预防疾病和疫苗接种史的数据:本研究对 2004 名符合条件的学生进行了评估,共纳入 593 人(29.6%),其中 250 人(42.7%)有流行性腮腺炎感染史。此外,分别有 264 名(44.6%)、31 名(5.2%)和 2 名(0.3%)学生接种了第一、第二和第三剂流行性腮腺炎疫苗。未接种组、接种第一剂、第二剂和第三剂组的腮腺炎血清阳性率分别为 43.2%(127 人)、36.7%(97 人)、26.7%(8 人)和 100% (2 人)(趋势 p = 0.09)。未注射、第一、第二和第三剂量组的腮腺炎感染率分别为 69.8%(n = 203)、11.3%(n = 28)、3.9%(n = 1)和 0%:结论:每10名只接种过一剂腮腺炎疫苗的学生中,约有1人有过突破性感染史。
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来源期刊
Journal of Public Health Research
Journal of Public Health Research PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
3.70
自引率
4.30%
发文量
116
审稿时长
10 weeks
期刊介绍: The Journal of Public Health Research (JPHR) is an online Open Access, peer-reviewed journal in the field of public health science. The aim of the journal is to stimulate debate and dissemination of knowledge in the public health field in order to improve efficacy, effectiveness and efficiency of public health interventions to improve health outcomes of populations. This aim can only be achieved by adopting a global and multidisciplinary approach. The Journal of Public Health Research publishes contributions from both the “traditional'' disciplines of public health, including hygiene, epidemiology, health education, environmental health, occupational health, health policy, hospital management, health economics, law and ethics as well as from the area of new health care fields including social science, communication science, eHealth and mHealth philosophy, health technology assessment, genetics research implications, population-mental health, gender and disparity issues, global and migration-related themes. In support of this approach, JPHR strongly encourages the use of real multidisciplinary approaches and analyses in the manuscripts submitted to the journal. In addition to Original research, Systematic Review, Meta-analysis, Meta-synthesis and Perspectives and Debate articles, JPHR publishes newsworthy Brief Reports, Letters and Study Protocols related to public health and public health management activities.
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