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Effect of electroacupuncture on total motile sperm count and sperm motility. 电针对活动精子总数和精子活力的影响
IF 1.6 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-09-03 eCollection Date: 2024-07-01 DOI: 10.1177/22799036241272394
Uki Retno Budihastuti, Bhisma Murti, Teguh Prakosa, Ida Nurwati, Abdurahman Laqif, Eriana Melinawati, Cahyono Hadi, Lunardhi Susanto, Metanolia Sukmawati, Hanung Prasetya, Agung Sari Wijayanti, Miftahul Falah Ahmad

Background: Approximately 50% of infertility cases are attributed to male factors. Acupuncture has long been employed as a complementary therapy to enhance male infertility treatment outcomes. This study aimed to assess the impact of electroacupuncture (EA) therapy on sperm motility and TMSC in male infertility patients.

Design and methods: This randomized clinical trial involved 30 male infertility patients divided into 2 groups. Consecutive sampling was utilized among men diagnosed with infertility at the Fertility Clinic Sekar, Dr. Moewardi General Hospital, Surakarta. Both groups underwent assessments of sperm motility and TMSC before and after the intervention. The first group received Coenzyme Q, while the second group received Coenzyme Q + EA.

Results: The Qoenzyme Q + EA group exhibited no significant difference in motility levels before treatment, with an average motility of 41.40% ± 13.33 and a TMSC level of 33.59 × 106 ± 27.91. Post-treatment, motility remarkably increased by 56.40% ± 11.78, and the TMSC level rose by 78.63 × 106 ± 58.38 in the Qoenzyme Q + EA group. Conversely, the Qoenzyme Q pre-treatment group had an average motility of 48.07% ± 15.77 and a TMSC level of 30.20 × 106 ± 34.82. After Coenzyme Q treatment, a significant decrease in motility by 42.80% ± 18.03 and TMSC level by 28.22 × 106 ± 15.16 was observed.

Conclusion: Combining Coenzyme Q + EA had a more significant impact on sperm motility and TMSC levels than Coenzyme Q alone. These findings underscore the differential effects of Coenzyme Q + EA and Coenzyme Q on sperm motility and TMSC levels, suggesting potential therapeutic implications for male reproductive health. Future studies with larger sample sizes are warranted to validate and expand upon these results.

背景:约 50%的不孕症病例归因于男性因素。长期以来,针灸一直被用作提高男性不育症治疗效果的辅助疗法。本研究旨在评估电针疗法对男性不育患者精子活力和TMSC的影响:这项随机临床试验涉及 30 名男性不育症患者,分为两组。在苏腊卡尔塔市莫瓦迪博士综合医院(Dr. Moewardi General Hospital)不孕不育诊所(Fertility Clinic Sekar)被诊断为不孕不育的男性中进行连续抽样。两组患者在干预前后均接受了精子活力和TMSC评估。第一组服用辅酶Q,第二组服用辅酶Q+EA:结果:辅酶Q+EA组的精子活力水平在治疗前无明显差异,平均活力为41.40%±13.33,TMSC水平为33.59×106±27.91。治疗后,Qoenzyme Q + EA 组的运动能力显著增加了 56.40% ± 11.78,TMSC 水平上升了 78.63 × 106 ± 58.38。相反,辅酶Q预处理组的平均运动能力为48.07%±15.77,TMSC水平为30.20×106±34.82。在辅酶Q治疗后,观察到运动能力显著下降(42.80% ± 18.03),TMSC水平显著下降(28.22 × 106 ± 15.16):结论:与单独使用辅酶Q相比,辅酶Q+EA组合对精子活力和TMSC水平的影响更为明显。这些发现强调了辅酶Q+EA和辅酶Q对精子活力和TMSC水平的不同影响,对男性生殖健康具有潜在的治疗意义。今后还需要进行更大规模的样本研究,以验证和扩展这些结果。
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引用次数: 0
Happiness among university students and associated factors: A cross-sectional study in Vietnam. 大学生的幸福感及相关因素:越南横断面研究。
IF 1.6 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-08-30 eCollection Date: 2024-07-01 DOI: 10.1177/22799036241272402
Pham Tien Nam, Pham Thanh Tung, Bui Phuong Linh, Nguyen Hanh Dung, Hoang Van Minh

Background: Happiness is among the fundamental concepts in mental health that have an impact on different aspects of university students. In this study, we aimed to estimate the prevalence of happiness among university students in Vietnam and to identify the factors influencing happiness.

Design and methods: A cross-sectional survey was conducted on undergraduate students in 8 universities and colleges in Hanoi, Vietnam. Happiness was measured using the Subjective Happiness Scale (SHS), and we used imputed Poisson regression to evaluate associations between happiness and associated factors.

Results: Among 9120 participants students (95.1% response rate), the prevalence of "happier group" was 80.9% (95% CI: 80.1-81.7). In the multivariable regression models, factors associated with being "less happy" on SHS were the perceived financial burden, year in university, academic motivation profile, and self-reported depression and anxiety.

Conclusions: University healthcare providers should pay attention to these associated factors while designing mental health care programs to promote happiness among university students.

背景:幸福感是心理健康的基本概念之一,对大学生的各个方面都有影响。在这项研究中,我们旨在估计越南大学生的幸福感,并确定影响幸福感的因素:对越南河内市 8 所大学和学院的本科生进行了横断面调查。幸福感采用主观幸福感量表(SHS)进行测量,我们使用归因泊松回归法评估幸福感与相关因素之间的关联:结果:在 9120 名参与调查的学生中(回复率为 95.1%),"更幸福群体 "的发生率为 80.9%(95% CI:80.1-81.7)。在多变量回归模型中,经济负担感知、大学年级、学习动机特征以及自我报告的抑郁和焦虑是与社会健康调查中 "不那么快乐 "相关的因素:结论:大学医护人员在设计心理保健计划时应注意这些相关因素,以提高大学生的幸福感。
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引用次数: 0
Knowledge, attitude, and practice towards dengue fever among medical students in Sudan: A cross-sectional study. 苏丹医科学生对登革热的认识、态度和实践:横断面研究。
IF 1.6 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-08-27 eCollection Date: 2024-07-01 DOI: 10.1177/22799036241270370
Muhannad Bushra Masaad Ahmed, Ahmed Balla M Ahmed, Salma Alrawa, Ahmed A Yeddi, Asim Jamal Mustafa Talha, Sohaib Mohammed Mokhtar Ahmed

Background: Dengue fever, a neglected tropical disease, exhibits a total seroprevalence of 27% in Sudan. During the recent outbreak, medical students actively participated in health education and community outreach programs. This study aims to assess the knowledge, attitude, and practice (KAP) of medical students regarding Dengue Fever (DF) during its current outbreak in Sudan.

Design and methods: We conducted a cross-sectional study involving medical students from more than 15 Sudanese universities, encompassing 11 states. Data collection took place between October 23 and November 10, 2023, utilizing a Google Form questionnaire. A convenient sampling technique was employed to reach students due to its accessibility and feasibility during the ongoing conflict in Sudan. Correlation and regression analyses were used to identify predictors of KAP and establish associations between KAP domains and socio-demographic factors.

Results: Of 694 medical students, 11% reported a previous infection with DF. Among the participants, 58% demonstrated good knowledge, 74.1% exhibited a positive attitude, and less than half (46.7%) demonstrated good preventive practices. There was a positive correlation between knowledge and attitude levels with the practice level (p < 0.001). Gender, age, and previous DF infection emerged as significant predictors (p < 0.05) of the overall KAP level in multiple logistic regression.

Conclusions: Our study revealed a commendable level of knowledge and attitude but a suboptimal level of practice regarding DF among medical students. This inadequacy in practice, particularly among medical students who are expected to set an example, is concerning and warrants further investigation.

背景:登革热是一种被忽视的热带疾病,在苏丹的总血清流行率为 27%。在最近的疫情爆发期间,医科学生积极参与了健康教育和社区外展计划。本研究旨在评估苏丹登革热疫情爆发期间医科学生对登革热的认识、态度和实践(KAP):我们开展了一项横断面研究,涉及苏丹 11 个州超过 15 所大学的医学生。数据收集工作于 2023 年 10 月 23 日至 11 月 10 日期间进行,使用的是谷歌表格问卷。由于苏丹冲突仍在持续,因此采用了方便抽样技术来接触学生。相关分析和回归分析用于确定 KAP 的预测因素,并建立 KAP 领域与社会人口因素之间的关联:在 694 名医科学生中,11% 的学生报告曾感染过 DF。其中,58%的学生表现出良好的知识水平,74.1%的学生表现出积极的态度,不到一半的学生(46.7%)表现出良好的预防措施。知识和态度水平与实践水平呈正相关(P P 结论):我们的研究显示,医学生对 DF 的认知和态度水平值得称赞,但实践水平却不尽如人意。这种实践上的不足令人担忧,尤其是在被期望树立榜样的医学生中,值得进一步研究。
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引用次数: 0
Dissemination and implementation science frameworks and strategies to increase breast cancer screening for at-risk women in the United States: A scoping review. 传播与实施科学框架和战略,以增加美国高危妇女的乳腺癌筛查:范围审查。
IF 1.6 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-08-05 eCollection Date: 2024-07-01 DOI: 10.1177/22799036241268841
Meera Rao, Sebastian Densley, Adeife Marciniak, Sara Burgoa, Yasmine Zerrouki, Goodness Okwaraji, Diana Lobaina, Vama Jhumkhawala, Michelle Knecht, Panagiota Kitsantas, Lea Sacca

Dissemination and implementation science (D&I) can help bridge the gap between research and practice by addressing how to facilitate and maintain pre-existing evidence-based interventions (EBIs) in various contexts within different fields, including that of breast cancer screening and treatment. Yet, despite the availability of D&I frameworks and strategies, there is a lack of studies exploring knowledge transfer dissemination and implementation models, strategies, and frameworks in the setting of breast cancer care. There is a need for studies that create guidelines and roadmaps built on theoretical foundations of D&I research to scale up successful D&I of strategies, frameworks, and protocols proven to cater to the needs of all breast cancer patients when seeking screening and treatment services. The Arksey and O'Malley (2005) York methodology was used as guidance for this review: (1) identifying research questions; (2) searching for relevant studies; (3) selecting studies relevant to the research questions; (4) charting the data; (5) collating, summarizing, and reporting results. Most cited barriers (n = 46) sorted into the category of "Recruitment, Measurement, and Delivery Challenges." The predominant ERIC strategy, featured in a noteworthy 84% of studies, was "Tailor strategies" (#16), which belongs to the "Adapt and tailor to context: culture, language, data analysis, collection" domain. This study can guide researchers, physicians, and community workers in improving accessibility, affordability, and quality of breast cancer screening and adequate follow-up opportunities through D&I strategies and models improving the reach and sustainability of evidence-based programs in at-risk female populations.

传播与实施科学(D&I)可以帮助缩小研究与实践之间的差距,解决如何在不同领域(包括乳腺癌筛查和治疗领域)的各种情况下促进和维持已有的循证干预措施(EBIs)。然而,尽管有 D&I 框架和策略,却缺乏在乳腺癌护理环境中探索知识转移传播和实施模式、策略和框架的研究。有必要开展研究,在设计与创新研究的理论基础上制定指导方针和路线图,以推广成功的设计与创新战略、框架和方案,这些战略、框架和方案已被证明能够满足所有乳腺癌患者在寻求筛查和治疗服务时的需求。本综述以 Arksey 和 O'Malley(2005 年)的约克方法论为指导:(1)确定研究问题;(2)搜索相关研究;(3)选择与研究问题相关的研究;(4)绘制数据图表;(5)整理、总结和报告结果。引用最多的障碍(n = 46)归类为 "招募、测量和交付挑战"。值得注意的是,有 84% 的研究采用了 ERIC 的主要策略,即 "量身定制策略"(第 16 项),该策略属于 "根据具体情况进行调整和定制:文化、语言、数据分析和收集 "领域。这项研究可以指导研究人员、医生和社区工作者通过 D&I 策略和模式提高乳腺癌筛查的可及性、可负担性和质量,并提供充分的随访机会,从而改善循证项目在高危女性群体中的覆盖面和可持续性。
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引用次数: 0
Social support in recently diagnosed diabetic patients: Risk factor for depression? 新近确诊的糖尿病患者的社会支持:抑郁症的风险因素?
IF 1.6 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-06-24 eCollection Date: 2024-04-01 DOI: 10.1177/22799036241262296
Mayut Delgado-Galeano, Lina-Maria Vera-Cala

Background: social support is important for adaptation in chronic diseases, such as diabetes and depression, because it favors recovery and adherence to treatment. Introducing its evaluation in the follow-up of diabetic patients can reduce complications derived from secondary non-adherence. Aims: to establish social support in diabetic patients and its correlation with depressive symptoms. Methods: a cross-sectional analytical study nested in a cohort of 173 recently diagnosed diabetic patients (<6 months) in Colombia over 18 years of age, treated in a cardiovascular risk program in 2022. The Chronic Illness Social Support Inventory was used. Results: Most of the participants were women (77.5%); single(83.8%), age (mean = 62.6 years (SD 12.3)); glycemia (mean = 146.4 (SD 65.5)), glycosylated hemoglobin (mean = 7.6 (SD 1.7)). Cronbach's α coefficient for the general scale of the social support instrument was 0.9859. The mean social support was 168.5 (SD 37.4), range 38-228. The total social support score was normally distributed (Shapiro Wilk p > 0.05). The correlation between domains was statistically significant. The PHQ9 total score was significantly associated with the domains of Personal Interaction and Guide but did not significantly correlate with the overall social support score. The respondents who were at risk of developing depression were referred for treatment. Conclusions: findings suggest that perceived social support may play a significant role in the prevention and treatment of depression in diabetic patients. It is desirable that health professionals consider evaluating and enhancing social support to improve their mental health. More research is needed to gain a comprehensive understanding of this relationship.

背景:社会支持对糖尿病和抑郁症等慢性疾病的适应非常重要,因为它有利于康复和坚持治疗。在对糖尿病患者进行随访时对其进行评估,可减少因继发性不坚持治疗而引起的并发症。目的:确定糖尿病患者的社会支持及其与抑郁症状的相关性。方法:一项横断面分析研究,嵌套于 173 名近期确诊的糖尿病患者队列中(结果:大部分参与者为女性(77.5%);单身(83.8%);年龄(平均 = 62.6 岁(标清 12.3));血糖(平均 = 146.4(标清 65.5));糖化血红蛋白(平均 = 7.6(标清 1.7))。社会支持工具一般量表的 Cronbach's α 系数为 0.9859。社会支持的平均值为 168.5 (SD 37.4),范围为 38-228。社会支持总分呈正态分布(Shapiro Wilk p > 0.05)。各领域之间的相关性具有统计学意义。PHQ9 总分与 "人际交往 "和 "向导 "领域有明显相关性,但与社会支持总分无明显相关性。有患抑郁症风险的受访者被转介接受治疗。结论:研究结果表明,感知到的社会支持可能在预防和治疗糖尿病患者抑郁症方面发挥重要作用。医护人员最好考虑评估和加强社会支持,以改善他们的心理健康。要全面了解这种关系,还需要进行更多的研究。
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引用次数: 0
Corrigendum. 更正。
IF 2.3 Q3 Medicine Pub Date : 2024-06-15 eCollection Date: 2024-04-01 DOI: 10.1177/22799036241264072

[This corrects the article DOI: 10.1177/22799036241246701.].

[此处更正了文章 DOI:10.1177/22799036241246701]。
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引用次数: 0
The association between neighborhood disadvantage and frailty: A retrospective case series. 邻里劣势与体弱之间的关系:回顾性病例系列
IF 1.6 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-06-10 eCollection Date: 2024-04-01 DOI: 10.1177/22799036241258876
David Fenton, Amani Allen, Johnathan R Kent, Rachel Nordgren, Allison Liu, Nihar Rama, Ally Wang, Daniel Rubin, Lauren J Gleason, A Justine Landi, Megan Huisingh-Scheetz, Mark K Ferguson, Maria Lucia L Madariaga

Background: Frailty predicts poorer outcomes in surgical patients. Recent studies have found socioeconomic status to be an important characteristic for surgical outcomes. We evaluated the association of Area Deprivation Index (ADI) and Social Vulnerability Index (SVI), two geospatial atlases that provide a multidimensional evaluation of neighborhood deprivation, with frailty in a surgery population.

Design & methods: A retrospective study of patients undergoing routine frailty screening was conducted 12/2020-8/2022. Frailty was measured using Fried's Frailty Phenotype (FFP) and the five-item Modified Frailty Index (mFI-5). ADI and SVI quartiles were determined using patient residence. Logistic regression models were used to evaluated associations of FFP (frail only vs not frail) and mFI-5 (≥2 vs 0-1) with ADI and SVI (α = 0.05).

Results: Of 372 screened patients, 41% (154) were women, median age was 68% (63-74), and 46% (170) identified as non-White. Across ADI and SVI quartiles, higher number of comorbidities, decreasing median income, and frailty were associated with increasing deprivation (p < 0.01). When controlling for age, sex, comorbidities, and BMI category, frailty by FFP was associated with the most deprived two quartiles of ADI (OR 2.61, CI: [1.35-5.03], p < 0.01) and the most deprived quartile of SVI (OR 2.33, [1.10-4.95], p < 0.05). These trends were also seen with mFI-5 scores ≥2 (ADI: OR 1.64, [1.02-2.63], p < 0.05; SVI: OR 1.71, [1.01-2.91], p < 0.05).

Conclusions: Surgical patients living in socioeconomically deprived neighborhoods are more likely to be frail. Interventions may include screening of disadvantaged populations and resource allocation to vulnerable neighborhoods.

背景:虚弱预示着手术患者的预后较差。最近的研究发现,社会经济状况是影响手术效果的一个重要特征。我们评估了地区贫困指数(ADI)和社会脆弱性指数(SVI)与手术人群虚弱程度的关系:2020 年 12 月至 2022 年 8 月,对接受常规虚弱筛查的患者进行了一项回顾性研究。虚弱程度采用弗里德虚弱表型(FFP)和五项修正虚弱指数(mFI-5)进行测量。ADI 和 SVI 四分位数根据患者居住地确定。采用逻辑回归模型评估 FFP(仅虚弱 vs 不虚弱)和 mFI-5(≥2 vs 0-1)与 ADI 和 SVI 的相关性(α = 0.05):在 372 名接受筛查的患者中,41%(154 人)为女性,年龄中位数为 68%(63-74 岁),46%(170 人)为非白人。在 ADI 和 SVI 四分位数中,合并症数量增加、收入中位数下降和体弱与贫困程度增加相关(p p p p p 结论:生活在社会经济贫困地区的手术患者更有可能体弱多病。干预措施可包括筛查弱势人群和为弱势社区分配资源。
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引用次数: 0
Predictors and components of inpatient asthma hospital cost: A retrospective cohort study. Analysis from a sample of 14 Belgian hospitals. 哮喘住院病人费用的预测因素和组成部分:一项回顾性队列研究。对比利时 14 家医院的抽样分析。
IF 2.3 Q3 Medicine Pub Date : 2024-05-05 eCollection Date: 2024-04-01 DOI: 10.1177/22799036241243270
Jehan Seret, Arnaud Bruyneel, Lionel Larcin, Fabienne Gooset, Djohra Azzi, Dimitri Martins, Julie Van Den Bulcke, Pol Leclercq, Magali Pirson

Background: Addressing the challenges of asthma has involved various approaches, including the examination of costs associated with hospitalization. However, there is a limited number of studies that have investigated the actual expenses incurred by hospital settings in caring for asthma patients. This study aims to describe the costs, predictors, and breakdown of expenditures in different categories.

Design and methods: A retrospective cohort study was conducted, involving 314 hospital stays of patients over 12 years old who were admitted for asthma and classified under APR-DRG 141 (asthma). Univariate and multiple linear regression analyses were performed.

Results: The median cost, regardless of DRG severity, amounted to 2.314€ (1.550€-3.847€). Significant variations were observed when the sample was stratified based on the severity of DRG, revealing a cost gradient that increases with severity. The length of stay followed a similar trend. Six predictors were identified: age, admission to intensive care, asthma severity, severity level of the DRG, winter admission, and length of stay. The cost breakdown showed that 44% constituted direct costs, 25% were indirect costs, 26% were attributed to medical procedures performed outside the patient unit, and 5% were related to medication administration.

Conclusions: This study initiates a discussion on the role of reducing hospital costs in strategies aiming at controlling asthma-related costs. We argue that cost reduction cannot be achieved solely at the hospital level but must be approached from a public health perspective. This includes promoting high-quality outpatient care and addressing factors leading to poor adherence to the care plan.

背景:应对哮喘挑战的方法多种多样,其中包括检查与住院相关的费用。然而,对医院在护理哮喘病人方面的实际支出进行调查的研究数量有限。本研究旨在描述不同类别的费用、预测因素和支出明细:本研究进行了一项回顾性队列研究,涉及 314 名因哮喘入院并被归入 APR-DRG 141(哮喘)的 12 岁以上住院患者。研究进行了单变量和多元线性回归分析:无论 DRG 严重程度如何,费用中位数均为 2.314 欧元(1.550-3.847 欧元)。如果根据 DRG 的严重程度对样本进行分层,则会观察到显著的差异,揭示出费用随严重程度而增加的梯度。住院时间也呈类似趋势。确定了六个预测因素:年龄、入住重症监护室、哮喘严重程度、DRG 的严重程度、冬季入院和住院时间。成本明细显示,44%为直接成本,25%为间接成本,26%归因于病房外的医疗程序,5%与用药有关:这项研究引发了关于降低医院成本在控制哮喘相关成本战略中的作用的讨论。我们认为,降低成本不能仅在医院层面实现,而必须从公共卫生的角度出发。这包括促进高质量的门诊护理,并解决导致护理计划执行不力的因素。
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引用次数: 0
Corrigendum. 更正。
IF 2.3 Q3 Medicine Pub Date : 2024-05-03 eCollection Date: 2024-04-01 DOI: 10.1177/22799036241254171

[This corrects the article DOI: 10.1177/22799036221106580.].

[此处更正了文章 DOI:10.1177/22799036221106580]。
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引用次数: 0
Mumps vaccination and immune status among Japanese university students: A multicenter cross-sectional study. 日本大学生的腮腺炎疫苗接种和免疫状况:一项多中心横断面研究
IF 2.3 Q3 Medicine Pub Date : 2024-05-01 eCollection Date: 2024-04-01 DOI: 10.1177/22799036241246702
Jiro Takeuchi, Iwata Ozaki, Kokichi Hata, Manami Nozawa, Kanami Fukushima, Norio Fukumori, Mie Imanaka, Yuta Sakanishi, Masayuki Shima, Takeshi Morimoto

Background: During the mumps outbreak in Japan in 2016, 159,031 cases were reported. In a survey conducted in 2015, mumps vaccination rates for the first dose were 30%-40%. However, the rates for two or more doses were not determined. We assessed the mumps vaccination rates and mumps infection prevalence according to vaccine doses received.

Design and methods: This was a multicenter cross-sectional study. Students from three universities participated in 2019. Informed consent was obtained from the students and their guardians. The primary outcome was the prevalence of breakthrough mumps infection according to the number of doses of vaccine received. We collected data on past illnesses of vaccine-preventable diseases and vaccination history using a questionnaire, photocopies of the Maternal and Child Health Handbook from the guardians, and virus antibody titers from the universities' health centers.

Results: This study assessed 2004 eligible students and included 593 (29.6%); of these, 250 (42.7%) had a mumps infection history. Furthermore, 264 (44.6%), 31 (5.2%), and 2 (0.3%) students received the first, second, and third doses of mumps vaccine, respectively. The mumps seropositivity prevalence was 43.2% (n = 127), 36.7% (n = 97), 26.7% (n = 8), and 100% (n = 2) for the no-, first-, second-, and third-dose groups, respectively (p for trend = 0.09). The mumps infection prevalence rates were 69.8% (n = 203), 11.3% (n = 28), 3.9% (n = 1), and 0% for the no-, first-, second-, and third-dose groups, respectively.

Conclusions: Approximately 1 in 10 students who had received only one dose of mumps-containing vaccine had a breakthrough infection history.

背景:2016 年日本流行性腮腺炎爆发期间,共报告了 159031 例病例。在 2015 年进行的一项调查中,第一剂腮腺炎疫苗的接种率为 30%-40%。但是,两剂或更多剂的接种率尚未确定。我们根据接种疫苗的剂量评估了腮腺炎疫苗接种率和腮腺炎感染率:这是一项多中心横断面研究。来自三所大学的学生参加了2019年的研究。研究获得了学生及其监护人的知情同意。主要结果是根据接种疫苗的剂量计算突破性腮腺炎感染率。我们通过问卷调查、监护人提供的《母子健康手册》复印件以及大学卫生中心提供的病毒抗体滴度,收集了有关既往患疫苗可预防疾病和疫苗接种史的数据:本研究对 2004 名符合条件的学生进行了评估,共纳入 593 人(29.6%),其中 250 人(42.7%)有流行性腮腺炎感染史。此外,分别有 264 名(44.6%)、31 名(5.2%)和 2 名(0.3%)学生接种了第一、第二和第三剂流行性腮腺炎疫苗。未接种组、接种第一剂、第二剂和第三剂组的腮腺炎血清阳性率分别为 43.2%(127 人)、36.7%(97 人)、26.7%(8 人)和 100% (2 人)(趋势 p = 0.09)。未注射、第一、第二和第三剂量组的腮腺炎感染率分别为 69.8%(n = 203)、11.3%(n = 28)、3.9%(n = 1)和 0%:结论:每10名只接种过一剂腮腺炎疫苗的学生中,约有1人有过突破性感染史。
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Journal of Public Health Research
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