The relationship between cognitive phenotypes of compulsivity and impulsivity and clinical variables in obsessive-compulsive disorder: A systematic review and Meta-analysis

IF 4.3 2区医学 Q1 PSYCHIATRY Comprehensive psychiatry Pub Date : 2024-04-27 DOI:10.1016/j.comppsych.2024.152491

Aaron T. Clarke , Naomi A. Fineberg , Luca Pellegrini , Keith R. Laws

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Abstract

Background

This systematic review and meta-analysis explored the relationship between cognitive phenotypes of compulsivity and impulsivity and clinical variables in obsessive-compulsive disorder (OCD).

Methods

We searched Pubmed, Scopus, Cochrane Library and PsychINFO databases until February 2023 for studies comparing patients with OCD and healthy controls on cognitive tests of compulsivity and impulsivity. The study followed PRISMA guidelines and was pre-registered on PROSPERO (CRD42021299017).

Results

Meta-analyses of 112 studies involving 8313 participants (4289 patients with OCD and 4024 healthy controls) identified significant impairments in compulsivity (g = −0.58, [95%CI -0.68, −0.47]; k = 76) and impulsivity (g = −0.48, [95%CI -0.57, −0.38]; k = 63); no significant difference between impairments. Medication use and comorbid psychiatric disorders were not significantly related to impairments. No associations were revealed with OCD severity, depression/anxiety, or illness duration.

Conclusion

Cognitive phenotypes of compulsivity and impulsivity in patients with OCD appear to be orthogonal to clinical variables, including severity of OCD symptomatology. Their clinical impact is poorly understood and may require different clinical assessment tools and interventions.

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强迫症患者强迫和冲动的认知表型与临床变量之间的关系：系统回顾与元分析。

背景：本系统综述和荟萃分析探讨了强迫症患者的强迫和冲动认知表型与临床变量之间的关系：本系统综述和荟萃分析探讨了强迫症（OCD）患者强迫性和冲动性认知表型与临床变量之间的关系：我们检索了Pubmed、Scopus、Cochrane Library和PsychINFO数据库中截至2023年2月关于强迫症患者与健康对照组在强迫性和冲动性认知测试方面的比较研究。该研究遵循了PRISMA指南，并在PROSPERO（CRD42021299017）上进行了预注册：对涉及 8313 名参与者（4289 名强迫症患者和 4024 名健康对照者）的 112 项研究进行了元分析，发现强迫性（g = -0.58，[95%CI -0.68，-0.47]；k = 76）和冲动性（g = -0.48，[95%CI -0.57，-0.38]；k = 63）存在显著损伤；损伤之间无显著差异。药物使用和合并精神障碍与障碍无明显关系。与强迫症严重程度、抑郁/焦虑或病程没有关联：结论：强迫症患者的强迫性和冲动性认知表型似乎与临床变量（包括强迫症症状的严重程度）正交。对它们的临床影响还不甚了解，可能需要不同的临床评估工具和干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Comprehensive psychiatry 医学-精神病学

CiteScore

12.50

自引率

1.40%

发文量

审稿时长

29 days

期刊介绍： "Comprehensive Psychiatry" is an open access, peer-reviewed journal dedicated to the field of psychiatry and mental health. Its primary mission is to share the latest advancements in knowledge to enhance patient care and deepen the understanding of mental illnesses. The journal is supported by a diverse team of international editors and peer reviewers, ensuring the publication of high-quality research with a strong focus on clinical relevance and the implications for psychopathology. "Comprehensive Psychiatry" encourages authors to present their research in an accessible manner, facilitating engagement with clinicians, policymakers, and the broader public. By embracing an open access policy, the journal aims to maximize the global impact of its content, making it readily available to a wide audience and fostering scientific collaboration and public awareness beyond the traditional academic community. This approach is designed to promote a more inclusive and informed dialogue on mental health, contributing to the overall progress in the field.