Comprehensive psychiatry最新文献

{"title":"Problematic usage of the internet and borderline personality disorder: A survey study in the United States.","authors":"Laurie Avila, Sophie Boutouis, Megha Neelapu, Jon E Grant","doi":"10.1016/j.comppsych.2026.152690","DOIUrl":"https://doi.org/10.1016/j.comppsych.2026.152690","url":null,"abstract":"<p><strong>Introduction: </strong>Adults with borderline personality disorder (BPD) are often diagnosed with co-occurring substance use disorders, but research regarding comorbid behavioral addictions, such as problematic usage of the internet (PUI), is sparse. Therefore, this study investigates the extent to which individuals with probable BPD struggle with PUI within an online community sample.</p><p><strong>Methods: </strong>An online survey titled \"Personality, Mental Health, and Well-Being\" was conducted using Prolific among a non-clinical sample of 300 adults (ages 18-76) from the United States in 2024. Probable BPD was identified using the McLean Screening Instrument for BPD (MSI-BPD). Participants with probable BPD were compared to those without probable BPD on demographics, Internet Severity and Activities Addiction Questionnaire (ISAAQ-10) severity scores, engagement in various online activities measured by the ISAAQ-10, dating app use, and responses to exploratory questions.</p><p><strong>Results: </strong>Of the 289 adults who completed the MSI-BPD, 13.1% (n = 38) screened positive for probable BPD. Compared to those without probable BPD, those with probable BPD scored higher on the ISAAQ-10 and were significantly more likely to meet our exploratory threshold for elevated PUI (33.3% versus 7.8%). Dating app use was more prevalent among individuals with probable BPD. In exploratory analyses, few reliable differences were observed across other specific online activities.</p><p><strong>Conclusion: </strong>Individuals with probable BPD reported higher levels of problematic internet use. Future studies should explore why and how people with BPD use the internet, especially whether online behaviors help with emotional regulation, avoidance, or validation-seeking.</p>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"147 ","pages":"152690"},"PeriodicalIF":4.2,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esports bettors versus traditional sports bettors: Differences in demographics, impulsivity, psychopathological symptoms, and gaming and gambling behavior","authors":"Harshdeep S. Mangat ,&nbsp;Orsolya Király ,&nbsp;Róbert Urbán ,&nbsp;Shu M. Yu ,&nbsp;Mark D. Griffiths ,&nbsp;Borbála Paksi ,&nbsp;Katalin Felvinczi ,&nbsp;Zsolt Demetrovics ,&nbsp;Andrea Czakó","doi":"10.1016/j.comppsych.2026.152667","DOIUrl":"10.1016/j.comppsych.2026.152667","url":null,"abstract":"<div><h3>Background and aims</h3><div>Esports betting (i.e., betting on the outcome of professional competitive videogaming matches) has become a regular feature of most online gambling websites in recent years. The present study compared differences between esports bettors and traditional sports bettors, in addition to exploring factors that predict participation in esports betting.</div></div><div><h3>Methods</h3><div>Data regarding demographics, impulsivity, psychopathological symptoms, gaming, and gambling among 359 esports bettors (mean age = 37.98 years [SD = 13.64]; 86.9% male) and 326 sports bettors (mean age = 43.79 years [SD = 13.75]; 91.7% male) from the United Kingdom, Hungary, and Canada were collected through surveys via two gambling service providers (<em>Betway</em> and <em>Midnite</em>) and a gaming magazine.</div></div><div><h3>Results</h3><div>Compared to sports bettors, esports bettors were significantly younger, scored higher on gambling risk severity, and had more gaming disorder symptoms. Esports bettors were also more likely than sports bettors to report higher levels of stress, anxiety, and depression symptoms, and impulsivity, as well as be driven by coping, social, and financial motives to engage in betting. In an unadjusted binary regression model, being younger, being driven by coping, social, and financial motives, and reporting elevated levels of impulsivity, depression, anxiety, and stress symptoms were predictors of esports betting. Higher rates of problem gambling severity and gaming disorder symptoms were also predictors of esports betting.</div></div><div><h3>Conclusions</h3><div>The findings suggest that esports bettors are a distinct betting group, and vulnerable to multiple gaming/gambling-related harms and psychopathological harms.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"146 ","pages":"Article 152667"},"PeriodicalIF":4.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loneliness in borderline personality disorder: The role of misalignments between self-view and social expectations in social value orientation and justice sensitivity","authors":"R. Vonderlin ,&nbsp;C. Claus ,&nbsp;S. Hanraths ,&nbsp;A.S. Lerchl ,&nbsp;B. Senyüz ,&nbsp;N. Kleindienst ,&nbsp;T. Boritz ,&nbsp;S. McMain ,&nbsp;T. Teismann ,&nbsp;P. Kirsch ,&nbsp;M. Bohus ,&nbsp;S. Lis","doi":"10.1016/j.comppsych.2026.152663","DOIUrl":"10.1016/j.comppsych.2026.152663","url":null,"abstract":"<div><h3>Background</h3><div>Loneliness is a pervasive and distressing feeling that characterizes social relationships in individuals with Borderline Personality Disorder (BPD). Previous research suggests that a misalignment between an individual's heightened prosocial self-view and their negative social expectations might contribute to loneliness. In the current quasi-experimental study, we investigated this discrepancy for social value orientation (SVO) and justice sensitivity (JS) and their relationship with loneliness.</div></div><div><h3>Methods</h3><div>A total of 120 participants (60 treatment-seeking individuals diagnosed with BPD, 60 non-clinical controls) assessed their SVO with the SVO-Slider-Task and their JS with the Justice-Sensitivity Inventory for experiencing injustice as a victim, observer, beneficiary and perpetrator. Additionally, participants rated their expectations about the SVO and JS of other people. We measured the individuals' level of loneliness with the UCLA Loneliness scale.</div></div><div><h3>Results</h3><div>Participants with BPD reported a stronger difference between self-view and social expectations compared to non-clinical controls for SVO (<em>r</em> = 0.18, <em>p</em> = .043) and other-oriented perspectives of JS (observer [<em>r</em> = 0.34], beneficiary [<em>r</em> = 0.48] and perpetrator [<em>r</em> = 0.27], all <em>p ≤</em> .003). A greater difference in observer and beneficiary JS was associated with higher levels of loneliness in the BPD group (observer: <em>r</em> = 0.31, <em>p</em> = .017, beneficiary: <em>r</em> = 0.44, <em>p</em> &lt; .001).</div></div><div><h3>Conclusion</h3><div>Alterations in self-views and social expectations in individuals with BPD might foster a vicious cycle of misunderstanding and disappointment in social relationships resulting in heightened feelings of loneliness. To improve interpersonal functioning and reduce loneliness, psychosocial interventions should target both the individual's heightened prosocial self-views and their negative expectations towards others.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"146 ","pages":"Article 152663"},"PeriodicalIF":4.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric comorbidities of posttraumatic stress disorder among adolescent refugees in Uganda: A latent class analysis of patterns and covariates","authors":"Herbert E. Ainamani ,&nbsp;Anne Wanjiru Mbwayo ,&nbsp;Muthoni Mathai ,&nbsp;Jonathan Hall ,&nbsp;Godfrey Z. Rukundo ,&nbsp;Florian Scharpf","doi":"10.1016/j.comppsych.2026.152672","DOIUrl":"10.1016/j.comppsych.2026.152672","url":null,"abstract":"<div><h3>Background</h3><div>Although psychiatric comorbidities are common among trauma-exposed individuals with PTSD, their patterns and covariates among refugee adolescents in low-resource settings remain understudied. This study aimed to identify distinct patterns of psychiatric comorbidities and their associated factors among adolescent refugees with PTSD in Nakivale refugee settlement, Uganda.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, 325 refugee youth were assessed on various PTSD psychiatric comorbidities and covariates of (age, gender, war trauma, post-migration stressors) using MINI International Neuropsychiatric Interview 7.02 and standardized measures of war trauma and post-migration stressors. Latent class analysis (LCA) was used to identify patterns and covariates of comorbidity.</div></div><div><h3>Results</h3><div>Of 269 adolescents with PTSD, 97% had at least one comorbid disorder: panic disorder (88.9%), generalized anxiety disorder (84%), agoraphobia (75.1%), depressive disorder (62.8%), obsessive compulsive disorder (60.6%), attention deficit disorder (43.9%), oppositional defiant disorder (40.9%), conduct disorder (33.8%), and alcohol use disorder (10.8%). LCA revealed three classes: low-moderate comorbidity (<em>n</em> = 66, 24.5%), high internalizing comorbidity (<em>n</em> = 101, 37.5%) with high probabilities of depression and anxiety disorders, and high overall comorbidity (<em>n</em> = 102, 37.9%) with relatively high probabilities of all disorders. The high overall comorbidity class had more girls than the other two classes. Both high comorbidity classes had higher war trauma and post-migration stressors than the low-moderate comorbidity class.</div></div><div><h3>Conclusions</h3><div>Adolescent refugees with PTSD exhibit high psychiatric comorbidity that clusters in distinct patterns. These findings highlight the need for interventions that address the identified comorbidity patterns, consider gender disparities, and account for cumulative trauma and post-migration stressors to effectively support traumatized youth.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"146 ","pages":"Article 152672"},"PeriodicalIF":4.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substance use behaviours among sexual and gender minorities with a history of adverse childhood experiences: a systematic review and narrative-synthesis","authors":"Eleanor J. Ong ,&nbsp;Kuhanesan N.C. Naidu ,&nbsp;Mervin Tee ,&nbsp;Rayner Kay Jin Tan ,&nbsp;Natasha Howard","doi":"10.1016/j.comppsych.2026.152669","DOIUrl":"10.1016/j.comppsych.2026.152669","url":null,"abstract":"<div><h3>Background and aims</h3><div>Adverse childhood experiences (ACEs) are linked to poor behavioural and mental health outcomes, including substance use, and disproportionately affect sexual and gender minorities (SGM). However, the relationship between ACEs and substance use in this population remains underexplored. This review investigates associations between ACEs and substance use outcomes in SGM adults.</div></div><div><h3>Design</h3><div>Registered with PROSPERO (CRD42024493936), we systematically searched six databases from inception to 13 April 2025. Following PRISMA guidelines, two authors independently screened studies and extracted data comparing substance use outcomes in SGM adults with and without ACEs histories. Due to heterogeneity, we conducted a narrative synthesis. Risk of bias was assessed using the 2019 Mixed Methods Appraisal Tool (MMAT).</div></div><div><h3>Participants and measurements</h3><div>Included studies involved SGM adults (≥18 years) who experienced at least one ACEs before age 18. SGM status encompassed lesbian, gay, bisexual, transgender, queer, intersex, non-binary, and other identities. Outcomes included any substance use (drug, alcohol, tobacco), with ACEs exposure as the primary variable.</div></div><div><h3>Findings</h3><div>Thirty-two studies (<em>N</em> = 43,197) were included. Twenty-nine epidemiological studies showed consistent associations between ACEs and negative substance use outcomes across SGM sub-groups and substances. Three qualitative studies highlighted links between substance use and child sexual abuse, heterosexism, and intersecting oppressions such as racism and institutionalization.</div></div><div><h3>Conclusions</h3><div>ACEs are associated with adverse substance use outcomes in SGM adults. Further research is needed on how intersecting marginalizations shape these associations.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"146 ","pages":"Article 152669"},"PeriodicalIF":4.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trauma-related pathways in obsessive-compulsive disorder: A systematic review of aetiology, symptom dimensions and severity","authors":"Margherita Zenoni ,&nbsp;Marina Rodriguez Lopez ,&nbsp;Stephanie Archer ,&nbsp;Amy L. Milton","doi":"10.1016/j.comppsych.2026.152664","DOIUrl":"10.1016/j.comppsych.2026.152664","url":null,"abstract":"<div><h3>Background</h3><div>Accumulating evidence suggests traumatic life experiences could influence the onset, symptomatology, and severity of Obsessive Compulsive Disorder (OCD). However, comprehensive insights into the relationship between trauma and OCD remain fragmented.</div></div><div><h3>Objectives</h3><div>To systematically examine the relationship between trauma and OCD across three critical domains: (1) the role of trauma in the aetiology of OCD; (2) the associations between specific trauma types and distinct OCD symptom dimensions; and (3) the impact of trauma on OCD severity and comorbid psychopathologies.</div></div><div><h3>Methods</h3><div>We conducted a systematic review following the PRISMA guidelines. Electronic searches were conducted in September 2025 using MEDLINE®, PsycINFO, and EMBASE, as it was forward citation tracking via Scopus.</div></div><div><h3>Results</h3><div>Twenty-eight studies met inclusion criteria from an initial pool of 157 identified papers. Evidence consistently indicated significant associations between traumatic life experiences – particularly emotional neglect, physical abuse, and sexual trauma - and the onset and exacerbation of OCD symptoms. Specific types of trauma predicted OCD symptom profiles. Interpersonal traumas were predominantly associated with obsessions of unacceptable thoughts and responsibility for harm, while non-interpersonal traumas were more strongly linked to contamination themes. Trauma exposure also increased OCD severity and psychiatric comorbidity risk.</div></div><div><h3>Conclusions</h3><div>Trauma seems to significantly amplify OCD symptom severity and influence symptom presentation. Trauma-informed clinical assessment and tailored interventions should be integral to OCD treatment.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"146 ","pages":"Article 152664"},"PeriodicalIF":4.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Habit as a therapeutic component in psychological treatment for obsessive-compulsive disorder: A randomised controlled feasibility study1","authors":"Ana Maria Frota Lisboa Pereira de Souza ,&nbsp;Davis Mpavaenda ,&nbsp;Paula Banca ,&nbsp;David Wellsted ,&nbsp;Janine Hopkins ,&nbsp;Aleya A. Marzuki ,&nbsp;Monika Lee ,&nbsp;Evmorfia Karafylli ,&nbsp;Olga Bardsley ,&nbsp;Sabina Mazoruk ,&nbsp;Stefanie Skalecki ,&nbsp;Shanti Boodhun ,&nbsp;Hannah Mendoza-Wolfson ,&nbsp;Claire Crispin ,&nbsp;Rebecca Aloneftis ,&nbsp;Deela Monji-Patel ,&nbsp;Eduardo Cinosi ,&nbsp;Luca Pellegrini ,&nbsp;Arun Enara ,&nbsp;Seema Panjwani ,&nbsp;Naomi A. Fineberg","doi":"10.1016/j.comppsych.2026.152666","DOIUrl":"10.1016/j.comppsych.2026.152666","url":null,"abstract":"<div><h3>Introduction</h3><div>Cognitive-behavioural therapy (CBT) with exposure and response prevention (ERP) represents a first-line intervention for obsessive-compulsive disorder (OCD), but many patients either do not tolerate or respond to it. Habit-reversal therapy (HRT) is used to treat a variety of disorders characterised by repetitive behaviours. HRT involves learning a non-pathological motor habit to help extinguish repetitive behaviour. Augmenting ERP with components of HRT represents a novel candidate treatment approach for OCD.</div></div><div><h3>Aims</h3><div>A randomised controlled trial (RCT) investigating the feasibility, acceptability, tolerability, and effectiveness of CBT + ERP augmented with a non-pathological habit in patients with OCD.</div></div><div><h3>Methods</h3><div>Forty-five treatment-seeking individuals with OCD were randomly allocated to 12 weeks CBT + ERP augmented with a smartphone-induced habit, comprising a learnt finger sequence, applied during exposure (<em>N</em> = 22) or 12 weeks CBT + ERP (<em>N</em> = 23) as the control. Participants randomised to the experimental arm underwent 6–8 weeks habit-training first. Participants were assessed using blinded-raters for OCD severity (Yale-Brown Obsessive-Compulsive Scale; Y-BOCS) (primary outcome), depression (Montgomery-Åsberg Depression Rating Scale; MADRS), anxiety (State-Trait Anxiety Inventory-State; STAI-S), intolerance of uncertainty (Intolerance of Uncertainty Scale; IUS), and functional disability (Sheehan Disability Scale; SDS). We applied a conservative, intent-to-treat (ITT) analysis using the last observation carried forward (LOCF).</div></div><div><h3>Results</h3><div>Twenty-eight (62%) participants (CBT + ERP + Habit = 11; CBT + ERP = 17) completed the trial. There was a significant reduction in Y-BOCS during habit-training (<em>p</em> &lt; .05), prior to initiation of any psychological treatment. There were no significant between-arm differences on the Y-BOCS or any other clinical rating, nor in premature discontinuation rates at the endpoint. However, a larger number of participants dropped out during the habit training phase (7/22). Reported adverse events (measured during the treatment phase) were significantly fewer in the experimental arm (<em>p</em> &lt; .001). Equivalent within-group improvement was seen in both arms on the Y-BOCS and IUS (all <em>p</em> &lt; .05). Only those within the control arm experienced improvement in the MADRS (<em>p</em> &lt; .01) and SDS (p &lt; .05). Anxiety did not change in either arm.</div></div><div><h3>Conclusion</h3><div>This small feasibility study limited by methodological confounds suggests habit-augmented CBT could be efficacious and well-tolerated in OCD. The improvements resulting from habit-training alone were unexpected and suggest novel treatment-approaches activating motor systems for OCD merit further investigation.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"146 ","pages":"Article 152666"},"PeriodicalIF":4.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146212423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empirical support for recognizing pathological buying/shopping as a mental disorder","authors":"Astrid Müller ,&nbsp;Matthias Brand ,&nbsp;Tobias A. Thomas ,&nbsp;Annica Kessling ,&nbsp;Anna M. Schmid ,&nbsp;Susana Jiménez-Murcia ,&nbsp;Elisa Wegmann ,&nbsp;Silke M. Müller ,&nbsp;Sabine Steins-Loeber","doi":"10.1016/j.comppsych.2026.152673","DOIUrl":"10.1016/j.comppsych.2026.152673","url":null,"abstract":"<div><h3>Objective</h3><div>To address the question of whether pathological buying/shopping differs from both risky and non-problematic buying/shopping.</div></div><div><h3>Method</h3><div>Post-hoc analysis of data collected within the Addiction Research Unit FOR2974. Three predefined groups, as determined by face-to-face diagnostic interviews, were compared: with pathological (pBSh, <em>n</em> = 62), risky (rBSh, n = 62), and non-problematic (control group, CG, <em>n</em> = 117) buying/shopping. Questionnaires were used to assess symptom severity (according to ICD-11 criteria for disorders due to addictive behaviors), functional impairment, craving, experience of gratification/compensation (all modified for buying/shopping), self-esteem, materialism, anxiety, depression, impulsiveness, and self-directedness. The laboratory testing included a cue reactivity paradigm and Go/No-Go affective shifting task with shopping-related cues, and standard tests for general cognitive functions (Stroop test, modified card sorting test, game of dice task, delay discounting task).</div></div><div><h3>Results</h3><div>The pBSh group exhibited more pathological scores in the questionnaires assessing ICD-11 criteria/features for disorders due to addictive behaviors (including distress, harm, gratification/compensation), self-esteem, anxiety, depression and steeper delay discounting than the other groups. Moreover, the pBSh group scored higher on materialism and impulsiveness, showed higher craving, and poorer performance in the Go/No-Go task than the CG. Applying Bonferroni corrected <em>p</em>-values, the groups did not differ in the Stroop test, modified card sorting test and game of dice task.</div></div><div><h3>Conclusion</h3><div>Pathological buying/shopping represents a distinct clinical syndrome that reflects underlying affective and cognitive dysfunctions and results in clinically significant distress and impairments. The findings provide further evidence of its classification as a disorder due to addictive behaviors.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"146 ","pages":"Article 152673"},"PeriodicalIF":4.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146257682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between borderline personality disorder symptomatology and major depressive disorder: Insights from a general population study","authors":"Eline Eigenhuis ,&nbsp;Margreet ten Have ,&nbsp;Marlous Tuithof ,&nbsp;Rosa E. Boeschoten ,&nbsp;Anna D.T. Muntingh ,&nbsp;Patricia C. van Oppen ,&nbsp;Neeltje M. Batelaan","doi":"10.1016/j.comppsych.2026.152670","DOIUrl":"10.1016/j.comppsych.2026.152670","url":null,"abstract":"<div><div>Understanding factors influencing the onset and course of major depressive disorder (MDD) is critical due to its frequently unfavorable prognosis. While Borderline Personality Disorder (BPD) seems to negatively affect the course of MDD, the role of subthreshold BPD symptoms remains unclear. This study investigated the impact of subthreshold BPD symptoms on the onset and persistence of MDD over a three-year follow-up in a general population sample of 4618 participants from the Netherlands Mental Health Survey and Incidence Study. MDD was assessed using the Composite International Diagnostic Interview 3.0 and BPD symptoms via the International Personality Examination. Logistic regression models were used. Respondents with 1–2 BPD symptoms (OR = 2.36, 95% CI = 1.56–3.56) and 3–4 BPD symptoms (OR = 4.36, 95% CI = 2.22–8.58) had significantly higher odds of developing MDD compared to those without BPD symptoms. These results remained robust after adjustment for potential confounders. Sensitivity analyses indicated BPD symptoms were linked to increased risk for both first onset and recurrence of MDD, with a seemingly stronger effect on recurrence. BPD symptoms were not significantly associated with MDD persistence, but limited power may have influenced this result. A significant dose-response relationship was observed for onset and recurrence, but not persistence. These findings suggest individuals with subthreshold BPD symptoms have elevated risk for new and recurrent depressive episodes, while no consistent association was observed with persistence of depression. Targeting BPD symptoms in (relapse) prevention may improve MDD outcomes.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"146 ","pages":"Article 152670"},"PeriodicalIF":4.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attentional bias in people with moderate-to-severe cannabis use disorder","authors":"Marianna Quinones-Valera ,&nbsp;Gary Chan ,&nbsp;Madeleine I. Fraser ,&nbsp;Andrew Jones ,&nbsp;Tom P. Freeman ,&nbsp;Chandni Hindocha ,&nbsp;Hannah Thomson ,&nbsp;Eugene McTavish ,&nbsp;Hannah Sehl ,&nbsp;Adam Clemente ,&nbsp;Janna Cousijn ,&nbsp;Izelle Labuschagne ,&nbsp;Peter Rendell ,&nbsp;Gill Terrett ,&nbsp;Lisa-Marie Greenwood ,&nbsp;Govinda Poudel ,&nbsp;Chao Suo ,&nbsp;Victoria Manning ,&nbsp;Valentina Lorenzetti","doi":"10.1016/j.comppsych.2025.152658","DOIUrl":"10.1016/j.comppsych.2025.152658","url":null,"abstract":"<div><h3>Background</h3><div>Attentional bias to cannabis images is posited to drive loss of control over cannabis use and relapse in cannabis use disorder (CUD), but the literature is mixed and limited by inconsistent measurement of CUD and of confounders, including alcohol and nicotine use. This study examined attentional bias in moderate-to-severe CUD (<em>n</em> = 66) compared to controls (<em>n</em> = 42), and its relationship with cannabis/nicotine use, accounting for alcohol use.</div></div><div><h3>Methods</h3><div>We measured attentional bias using the visual probe task, as the difference in reaction times (RTs) for cannabis versus neutral images, in order to account for individual variability. Linear mixed effect models examined how RTs were affected by (i) group (CUD, control), image type (cannabis, neutral), group-by-image type, and group-by-image type-by-Stimulus Onset Asynchrony (SOA, 200/500 milliseconds) in the whole sample; and (ii) by image type, SOA, and moderators in the CUD group only (i.e., Cannabis Use Disorder Identification Test-Revised [CUDIT-R], subjective craving, arousal/valence ratings of the task’s cannabis/neutral images, and nicotine). All models were adjusted for alcohol use.</div></div><div><h3>Results</h3><div>There were no significant group differences in attentional bias. In the CUD group, image type-by-CUDIT-R subgroups differed on RTs (β = −0.748, <em>p</em> = .014), whereby the high-CUDIT-R versus lower CUDIT-R subgroups had significantly faster RTs to cannabis versus neutral images (<em>p</em> = .034, <em>d</em> = −0.10), but this effect did not survive Bonferroni correction for multiple comparisons. No other results were significant.</div></div><div><h3>Conclusion</h3><div>Attentional bias might not be a robust feature of CUD, though this notion requires validation in a larger sample using more direct measures of attentional bias.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"146 ","pages":"Article 152658"},"PeriodicalIF":4.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145963090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}