Thyroid cancer prognostic biomarker ARL4A and its relationship with immune infiltration.

IF 1.1 Q4 ONCOLOGY International journal of clinical and experimental pathology Pub Date : 2024-04-15 eCollection Date: 2024-01-01 DOI:10.62347/JEIV8228

Xiaoyong Han, Jianping Liao, Yaoping Zhou, Xiaohua Hu, Haishan Wu

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Abstract

Background: Thyroid cancer (THCA) is a prevalent form of cancer with high rates of morbidity and mortality. The small GTPase ADP-ribosylation factor-like 4A (ARL4A) is integral to various cellular processes, including cytoskeletal restructuring, vesicular transport, cell migration, and neuronal development. However, the role of ARL4A as a clinical predictor, particularly its relation to immune cell infiltration in THCA, remains unclear.

Methods: A combination of experimental studies and analysis of online databases was employed to investigate ARL4A expression in THCA. Clinical and pathological data from THCA patients were compiled for a comprehensive subgroup analysis. The Kaplan-Meier and Cox regression methods were utilized to evaluate the prognostic significance of ARL4A in THCA patients. Finally, the "Cancer Genome Atlas" was analyzed to explore the correlation between immune cell infiltration, ARL4A expression, and their joint impact on prognosis.

Results: ARL4A exhibited low expression in THCA. An elevated ARL4A was associated with poor prognosis. Moreover, the expression of ARL4A was correlated with the age, gender, and pathological stage of THCA patients. Finally, ARL4A expression was found to be negatively correlated with immune cell infiltration and influenced the prognosis of patients through changes in the immune environment.

Conclusion: ARL4A may serve as a potential biomarker for the diagnosis and treatment of THCA, impacting the prognosis of patients through the modulation of the immune microenvironment.

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甲状腺癌预后生物标志物 ARL4A 及其与免疫浸润的关系

背景：甲状腺癌（THCA）是一种发病率和死亡率都很高的常见癌症。小 GTPase ADP-ribosylation factor-like 4A (ARL4A) 是各种细胞过程（包括细胞骨架重组、囊泡运输、细胞迁移和神经元发育）不可或缺的组成部分。然而，ARL4A作为临床预测因子的作用，尤其是它与THCA中免疫细胞浸润的关系仍不清楚：方法：结合实验研究和在线数据库分析，研究 ARL4A 在 THCA 中的表达。对THCA患者的临床和病理数据进行了汇总，以进行综合亚组分析。利用 Kaplan-Meier 和 Cox 回归法评估 ARL4A 在 THCA 患者中的预后意义。最后，分析了 "癌症基因组图谱"，以探讨免疫细胞浸润、ARL4A表达之间的相关性及其对预后的共同影响：结果：ARL4A在THCA中低表达。结果：ARL4A在THCA中表现为低表达，ARL4A的升高与预后不良有关。此外，ARL4A的表达与THCA患者的年龄、性别和病理分期相关。最后，ARL4A的表达与免疫细胞浸润呈负相关，并通过免疫环境的变化影响患者的预后：ARL4A可作为诊断和治疗THCA的潜在生物标志物，通过调节免疫微环境影响患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International journal of clinical and experimental pathology ONCOLOGY-PATHOLOGY

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1 months

期刊介绍： The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.