Follow-up of Methanol-related Visual Defects in a Cohort Study: Initial Severity Predicts Long-term Outcome.

IF 0.8 Q4 PHARMACOLOGY & PHARMACY Journal of Research in Pharmacy Practice Pub Date : 2024-04-30 eCollection Date: 2023-07-01 DOI:10.4103/jrpp.jrpp_80_22
Farzad Gheshlaghi, Anselm Wong, Rezvan Firuzfar, Keyvan Jenab, Shayan Gheshlaghi, Golnoosh Shahverdi, Nastaran Eizadi-Mood
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Abstract

Objective: Methanol poisoning can occur either intentionally through the consumption of methanol-containing products or accidentally through ingestion, resulting in visual impairment. We assessed the long-term visual sequelae in patients with methanol poisoning.

Methods: This prospective cohort study was conducted at referral centers, Khorshid and Alzahra University Hospitals, affiliated with Isfahan University of Medical Sciences, Isfahan, Iran. The study included patients hospitalized for methanol poisoning from June 22, 2018, to June 21, 2020, with follow-up extended until June 2021. Toxico-clinical and ophthalmologic examination data were collected from patients upon hospital admission, discharge, and during follow-up.

Findings: Thirty-nine patients were assessed in this study. The majority of them (94.9%) were male, with an average age of 34 years. Patients who presented with reduced visual acuity (VA) upon admission subsequently showed abnormalities (in acuity and visual fields) during follow-up (n = 13). Among the patients who displayed visual field defects on admission, bilateral optic disc atrophy was observed in follow-up (n = 13). Conversely, patients who reported blurred vision, with or without photophobia upon admission, had normal results in their follow-up eye examinations. Among the 36 patients who underwent dialysis, 14 (38.9%) exhibited visual impairment during follow-up examinations. Additionally, 38 patients received sodium bicarbonate, and 14 of them (36.85%) also presented ocular abnormalities.

Conclusion: Patients who demonstrated VA deficits upon admission are more likely to experience long-term VA and visual field defects, as well as optic disc atrophy. Patients who solely complained of blurred vision, with or without photophobia, during admission were less likely to develop long-term visual defects.

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一项队列研究中甲醇相关视力缺陷的随访:最初的严重程度可预测长期结果。
目的:甲醇中毒可因有意食用含甲醇的产品或意外摄入而导致视力受损。我们对甲醇中毒患者的长期视觉后遗症进行了评估:这项前瞻性队列研究在伊朗伊斯法罕市伊斯法罕医科大学附属霍尔希德和阿尔扎赫拉大学医院转诊中心进行。研究对象包括 2018 年 6 月 22 日至 2020 年 6 月 21 日期间因甲醇中毒住院的患者,随访期延长至 2021 年 6 月。研究收集了患者入院、出院和随访期间的毒物临床和眼科检查数据:本研究评估了 39 名患者。其中大部分(94.9%)为男性,平均年龄为 34 岁。入院时视力(VA)下降的患者在随访期间出现视力和视野异常(13 人)。在入院时出现视野缺损的患者中,随访期间观察到双侧视盘萎缩(13 人)。相反,入院时报告视力模糊并伴有或不伴有畏光的患者,其后续眼科检查结果均正常。在接受透析的 36 名患者中,有 14 人(38.9%)在随访检查中出现视力障碍。此外,38 名患者接受了碳酸氢钠治疗,其中 14 人(36.85%)也出现了眼部异常:结论:入院时出现视力障碍的患者更有可能出现长期视力和视野缺损以及视盘萎缩。入院时仅主诉视力模糊、伴有或不伴有畏光的患者出现长期视力缺陷的可能性较小。
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来源期刊
Journal of Research in Pharmacy Practice
Journal of Research in Pharmacy Practice PHARMACOLOGY & PHARMACY-
自引率
0.00%
发文量
8
审稿时长
21 weeks
期刊介绍: The main focus of the journal will be on evidence-based drug-related medical researches (with clinical pharmacists’ intervention or documentation), particularly in the Eastern Mediterranean region. However, a wide range of closely related issues will be also covered. These will include clinical studies in the field of pharmaceutical care, reporting adverse drug reactions and human medical toxicology, pharmaco-epidemiology and toxico-epidemiology (poisoning epidemiology), social aspects of pharmacy practice, pharmacy education and economic evaluations of treatment protocols (e.g. cost-effectiveness studies). Local reports of medication utilization studies at hospital or pharmacy levels will only be considered for peer-review process only if they have a new and useful message for the international pharmacy practice professionals and readers.
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