HYL1's multiverse: A journey through miRNA biogenesis and beyond canonical and non-canonical functions of HYL1

IF 8.3 2区 生物学 Q1 PLANT SCIENCES Current opinion in plant biology Pub Date : 2024-05-07 DOI:10.1016/j.pbi.2024.102546
Lucia Gonzalo , Axel J. Giudicatti , Pablo A. Manavella
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Abstract

A delicate balance in gene expression, a process highly controlled by post-transcriptional gene silencing mediated by miRNAs, is vital during plant growth and responses to stress. Within the miRNA biogenesis pathway, HYL1 is one of the most important proteins, initially recognized for its role as a cofactor of DCL1. Yet, HYL1's functions extend beyond miRNA processing, encompassing transcriptional regulation and protein translation between other recently discovered functions. This review comprehensively examines our current knowledge of HYL1 functions in plants, looking at its structure, the complex biochemistry behind it, and its involvement in a variety of cellular processes. We also explored the most compelling open questions regarding HYL1 biology and the further perspectives in its study. Unraveling HYL1 functional details could better understand how plants grow, face environmental stresses, and how the miRNA pathway adapts its outcome to the plant growing conditions.

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HYL1 的多重宇宙:穿越 miRNA 的生物发生,超越 HYL1 的规范和非规范功能
基因表达的微妙平衡是一个由 miRNA 介导的转录后基因沉默高度控制的过程,在植物生长和应对胁迫的过程中至关重要。在 miRNA 生物发生途径中,HYL1 是最重要的蛋白质之一,最初被认为是 DCL1 的辅助因子。然而,HYL1 的功能并不局限于 miRNA 处理,还包括转录调控和蛋白质翻译等新发现的功能。这篇综述全面考察了我们目前对 HYL1 在植物中功能的了解,研究了它的结构、背后复杂的生物化学以及它在各种细胞过程中的参与。我们还探讨了有关 HYL1 生物学的最引人注目的开放性问题以及进一步研究的前景。揭示 HYL1 的功能细节可以更好地了解植物如何生长、如何面对环境压力以及 miRNA 途径如何使其结果适应植物生长条件。
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来源期刊
Current opinion in plant biology
Current opinion in plant biology 生物-植物科学
CiteScore
16.30
自引率
3.20%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Current Opinion in Plant Biology builds on Elsevier's reputation for excellence in scientific publishing and long-standing commitment to communicating high quality reproducible research. It is part of the Current Opinion and Research (CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy - of editorial excellence, high-impact, and global reach - to ensure they are a widely read resource that is integral to scientists' workflow.
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