{"title":"Conversion of flat to cylindrical hydrogel structures by asymmetric crosslinking and ionic exchange","authors":"Shumin Liang , Qing Chen , Xiaowen Huang , Bingbing Yang , Yicheng Guo , Panče Naumov , Lidong Zhang","doi":"10.1016/j.cej.2024.151906","DOIUrl":null,"url":null,"abstract":"<div><p>The similarity of hydrogels with human soft tissues serves a two-fold purpose: they are convenient, humane tissue substitutes for biomedical testing, while they are also a reliable platform for the development of biocompatible implantable devices and organoids. However, these assets come with challenges with reproducible processing of stable hollow structures that are common transducers of liquids in living organisms, from two-dimensional polymeric precursors. Here, we describe a protocol for film-to-tube transformation that is devoid of templates, catalysts, 3D printing, heating, and light, and can be used to prepare hollow hydrogel structures. The resulting hydrogel tubes have tensile strength of up to 45 MPa, turning these materials into the most robust hydrogel materials reported to date. The flexibility and elasticity favor the resulting hydrogel tubes for catheterization of artificial intestinal demonstrating the potential for medical applications. The approach can be applied to prepare structure/function-mimetic organoids such as branched blood vessels and nephrons with higher resolution than additive manufacturing. Then hollow structures are degradable in alkaline solution, and the solution can be recycled to recover the tubular structures. The convenience of the approach described overcomes some of the most challenging aspects of preparation of hollow hydrogel elements.</p></div>","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":null,"pages":null},"PeriodicalIF":13.3000,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Engineering Journal","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S138589472403393X","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}
引用次数: 0
Abstract
The similarity of hydrogels with human soft tissues serves a two-fold purpose: they are convenient, humane tissue substitutes for biomedical testing, while they are also a reliable platform for the development of biocompatible implantable devices and organoids. However, these assets come with challenges with reproducible processing of stable hollow structures that are common transducers of liquids in living organisms, from two-dimensional polymeric precursors. Here, we describe a protocol for film-to-tube transformation that is devoid of templates, catalysts, 3D printing, heating, and light, and can be used to prepare hollow hydrogel structures. The resulting hydrogel tubes have tensile strength of up to 45 MPa, turning these materials into the most robust hydrogel materials reported to date. The flexibility and elasticity favor the resulting hydrogel tubes for catheterization of artificial intestinal demonstrating the potential for medical applications. The approach can be applied to prepare structure/function-mimetic organoids such as branched blood vessels and nephrons with higher resolution than additive manufacturing. Then hollow structures are degradable in alkaline solution, and the solution can be recycled to recover the tubular structures. The convenience of the approach described overcomes some of the most challenging aspects of preparation of hollow hydrogel elements.
期刊介绍:
The Chemical Engineering Journal is an international research journal that invites contributions of original and novel fundamental research. It aims to provide an international platform for presenting original fundamental research, interpretative reviews, and discussions on new developments in chemical engineering. The journal welcomes papers that describe novel theory and its practical application, as well as those that demonstrate the transfer of techniques from other disciplines. It also welcomes reports on carefully conducted experimental work that is soundly interpreted. The main focus of the journal is on original and rigorous research results that have broad significance. The Catalysis section within the Chemical Engineering Journal focuses specifically on Experimental and Theoretical studies in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. These studies have industrial impact on various sectors such as chemicals, energy, materials, foods, healthcare, and environmental protection.