{"title":"A pH/Redox Dual-Responsive Nanocarrier for Hypoxia-Activated Prodrug and Anticancer Prodrug in Cancer Treatment","authors":"Jhin Chen Ho, Ching-Yi Chen","doi":"10.1002/macp.202470018","DOIUrl":null,"url":null,"abstract":"<p><b>Front Cover</b>: A pH/redox dual-responsive and dual chemotherapeutic PNA and hypoxia-activated AQ4N prodrug micelle is developed for targeting endogenous tumor microenvironment heterogeneity. This new micelle system provides an effective strategy to increase the drug stability and reduce toxicity or side effects under physiological conditions, trigger intracellular release of potent drugs as well as enhance the therapeutic efficiency via combined chemotherapy and hypoxia-activated cancer treatment. More details can be found in article number 2300386 by Jhin Chen Ho and Ching-Yi Chen.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":"225 9","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/macp.202470018","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Macromolecular Chemistry and Physics","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/macp.202470018","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
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Abstract
Front Cover: A pH/redox dual-responsive and dual chemotherapeutic PNA and hypoxia-activated AQ4N prodrug micelle is developed for targeting endogenous tumor microenvironment heterogeneity. This new micelle system provides an effective strategy to increase the drug stability and reduce toxicity or side effects under physiological conditions, trigger intracellular release of potent drugs as well as enhance the therapeutic efficiency via combined chemotherapy and hypoxia-activated cancer treatment. More details can be found in article number 2300386 by Jhin Chen Ho and Ching-Yi Chen.
期刊介绍：
Macromolecular Chemistry and Physics publishes in all areas of polymer science - from chemistry, physical chemistry, and physics of polymers to polymers in materials science. Beside an attractive mixture of high-quality Full Papers, Trends, and Highlights, the journal offers a unique article type dedicated to young scientists – Talent.
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