Hydrogels Based on Gellan and a Graft Copolymer of Pullulan with Poly(2-methyl-2-oxazoline) Side Groups

IF 0.8 Q3 Engineering Nanotechnologies in Russia Pub Date : 2024-03-23 DOI:10.1134/S2635167623601481
A. A. Lezov, V. B. Rogozhin, A. A. Lezova, N. G. Mikusheva, I. Yu. Perevyazko, G. E. Polushina, A. S. Gubarev, I. M. Zorin, N. V. Tsvetkov
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Abstract

In this work, a three-component system is obtained based on gellan, a graft copolymer of pullulan with side chains of poly(2-methyl-2-oxazoline), and CaCl2, which is capable of forming gels upon contact with an aqueous solution of NaCl. Such a composition can be used for medical purposes, in particular for the treatment of ophthalmological diseases. In this work, the molecular characteristics of the initial components of the gel are obtained and its viscoelastic properties are studied. It was established that graft copolymers of pullulan with poly(2-methyl-2-oxazoline) are integrated into the gel composition, while an increase in their proportion reduces its elastic properties. The obtained gel retain elastic properties upon heating up to 70°C.

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基于结冷胶和普鲁兰与聚(2-甲基-2-噁唑啉)侧基的接枝共聚物的水凝胶
摘要 在这项工作中,获得了一种基于结冷胶(一种带有聚(2-甲基-2-噁唑啉)侧链的拉鲁拉接枝共聚物)和 CaCl2 的三组分体系,该体系在与 NaCl 水溶液接触时能够形成凝胶。这种组合物可用于医疗目的,特别是用于治疗眼科疾病。这项研究获得了凝胶初始成分的分子特征,并对其粘弹性能进行了研究。结果表明,拉普兰与聚(2-甲基-2-噁唑啉)的接枝共聚物与凝胶成分融为一体,而增加其比例则会降低凝胶的弹性特性。所获得的凝胶在加热至 70°C 时仍能保持弹性特性。
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来源期刊
Nanotechnologies in Russia
Nanotechnologies in Russia NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
1.20
自引率
0.00%
发文量
0
期刊介绍: Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.
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