Nanocomplexes of the Anthracycline Antibiotic Daunomycin and Doxorubicin with Selenium Nanoparticles and Polyvinylpyrrolidone: Spectral and Dimensional Characteristics

Abstract

The influence of the hydroxyl group in the aglycone of the antitumor antibiotic doxorubicin on the spectrophotometric and dimensional characteristics of nanocomplexes of doxorubicin–polyvinylpyrrolidone–selenium nanoparticles is established. The involvement of components of ternary complexes in intermolecular interactions is assessed using the spectrophotometric method. The radii of gyration (40–60 nm) and hydrodynamic radii (20–70 nm) of the synthesized nanocomplexes are determined using static- and dynamic-light scattering methods. The hydroxyl group present in the structure of the antitumor antibiotic contributed to the formation in an aqueous environment of a more loose, permeable shell of the nanocomplex compared to the daunomycin–polyvinylpyrrolidone–selenium nanoparticles nanocomplexes. An increase in the Se concentration during the synthesis of nanocomplexes leads to expansion of the loose shell. The revealed patterns will further contribute to the development of methods for synthesizing nanocomplexes for the modification of water-soluble antitumor antibiotics.