Assessment of particle contamination in vancomycin syringe pumps following fluid withdrawal using three diverse aseptic reconstitution techniques

Abstract

The recommended approach for administering vancomycin involves intermittent peripheral infusion at a concentration of 5 mg/mL,1 while continuous central venous infusion has gained ground due to the reduced risk of renal injury and heightened probability of attaining pharmacokinetic objectives compared with intermittent dosing.2 However, adhering to the recommended concentration of 5 mg/mL for continuous vancomycin administration notably increases the total volume and necessitates frequent syringe replacements compared with concentrations ≥20 mg/mL. Within our hospital setting, vancomycin is administered via continuous infusion at a concentration of 40 mg/mL to mitigate fluid overload and reduce the need for frequent syringe changes. Recently, Masse et al demonstrated that non-filtered vancomycin solutions at concentrations ranging from 25 to 80 mg/mL diluted in sodium chloride (NaCl) 0.9% and water for injections exceeded the European Pharmacopoeia …