Toll-Like Receptor Gene Polymorphisms in a Population-Based Study of HIV and Tuberculosis Patients from Eastern Europe and Central Asia

IF 0.6 4区生物学 Q4 GENETICS & HEREDITY Russian Journal of Genetics Pub Date : 2024-05-03 DOI:10.1134/s1022795424040124

S. A. Salamaikina, V. I. Korchagin, K. O. Mironov, E. I. Kulabukhova, V. N. Zimina, A. V. Kravtchenko

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Abstract

Genetic diversity of human populations is determined by polymorphic variants of immune response genes and can be linked to the variation in responses to infectious agents. This study compared allele and genotype frequencies of polymorphic variants of the TLR1, TLR2, TLR4, TLR6, and TLR8 genes between samples from Eastern Europe and Central Asia. We included 680 unrelated individuals from Eastern Slavic (n = 308), Armenian (n = 137), Tajik (n = 138), and Kyrgyz (n = 97) samples of patients with confirmed diagnoses of HIV and tuberculosis. The international 1000 Genomes Project data—samples of Caucasians (EUR) and countries of eastern (EAS) and southern (SAS) Asia—were used for comparison. Despite the lack of genetic diversity and population differences in allele frequencies of the analyzed genes, the samples differed in a number of loci both from each other and from EAS and SAS samples.

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东欧和中亚艾滋病毒和结核病患者人群研究中的 Toll-Like 受体基因多态性

摘要人类种群的遗传多样性由免疫反应基因的多态变异决定，并可能与对感染性病原体的反应差异有关。本研究比较了东欧和中亚样本中 TLR1、TLR2、TLR4、TLR6 和 TLR8 基因多态变体的等位基因和基因型频率。我们纳入了来自东斯拉夫语（n = 308）、亚美尼亚语（n = 137）、塔吉克语（n = 138）和吉尔吉斯语（n = 97）样本中的 680 个无亲属关系的人，这些样本都是确诊为 HIV 和结核病的患者。国际千人基因组计划数据--高加索人（EUR）以及亚洲东部（EAS）和南部（SAS）国家的样本--用于比较。尽管所分析基因的等位基因频率缺乏遗传多样性和人群差异，但样本之间以及样本与东亚和南亚样本之间在一些位点上存在差异。

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来源期刊

Russian Journal of Genetics 生物-遗传学

CiteScore

1.00

自引率

33.30%

发文量

126

审稿时长

1 months

期刊介绍： Russian Journal of Genetics is a journal intended to make significant contribution to the development of genetics. The journal publishes reviews and experimental papers in the areas of theoretical and applied genetics. It presents fundamental research on genetic processes at molecular, cell, organism, and population levels, including problems of the conservation and rational management of genetic resources and the functional genomics, evolutionary genomics and medical genetics.