Expression Profile and Relationships between microRNAs as Biomarkers in COPD Patients

IF 0.6 4区 生物学 Q4 GENETICS & HEREDITY Russian Journal of Genetics Pub Date : 2024-05-03 DOI:10.1134/s1022795424040082
N. Moattar-Husseini, N. Bahrami, F. Hosseini, H. Jamaati, M. Kazempour-Dizaji, Sh. Shafaghi, S. Noorali, A. Mohamadnia
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Abstract

Chronic obstructive pulmonary disease is a chronic inflammatory lung disease that causes airflow obstruction in the lungs. In fact, it is a lung disease that can cause involvement of respiratory tracts, lung tissue or blood vessels. There is still no accurate diagnostic tool for COPD. Among various biomarkers, the current review focuses on different types of miRNAs in COPD which have been studied. Many target cells and molecules, microRNAs are involved in the pathogenesis of COPD. MicroRNAs are a group of protected short single-stranded RNAs between 19 and 23 nucleotides and non-coding, which act as post-transcriptional regulators in animals, plants and viruses. In this article, the aim is to collect and categorize the studies conducted in the field of microRNA as biomarkers in COPD patients.

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慢性阻塞性肺病患者体内作为生物标记物的 microRNA 的表达谱及其相互关系
摘要 慢性阻塞性肺病是一种慢性炎症性肺病,会导致肺部气流阻塞。事实上,它是一种可累及呼吸道、肺组织或血管的肺部疾病。慢性阻塞性肺病至今仍没有准确的诊断工具。在各种生物标志物中,目前的综述侧重于慢性阻塞性肺病中已研究过的不同类型的 miRNA。许多靶细胞和分子、microRNA 都参与了慢性阻塞性肺病的发病机制。microRNAs是一组受保护的短单链RNA,介于19至23个核苷酸之间,非编码,在动物、植物和病毒中起转录后调节作用。本文旨在收集整理有关微RNA作为慢性阻塞性肺病患者生物标志物的研究。
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来源期刊
Russian Journal of Genetics
Russian Journal of Genetics 生物-遗传学
CiteScore
1.00
自引率
33.30%
发文量
126
审稿时长
1 months
期刊介绍: Russian Journal of Genetics is a journal intended to make significant contribution to the development of genetics. The journal publishes reviews and experimental papers in the areas of theoretical and applied genetics. It presents fundamental research on genetic processes at molecular, cell, organism, and population levels, including problems of the conservation and rational management of genetic resources and the functional genomics, evolutionary genomics and medical genetics.
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