{"title":"Deciphering CD4<sup>+</sup> T cell-mediated responses against cancer.","authors":"Catherine Kirkpatrick, Yong-Chen William Lu","doi":"10.1002/mc.23730","DOIUrl":null,"url":null,"abstract":"<p><p>It's been long thought that CD8<sup>+</sup> cytotoxic T cells play a major role in T cell-mediated antitumor responses, whereas CD4<sup>+</sup> T cells merely provide some assistance to CD8<sup>+</sup> T cells as the \"helpers.\" In recent years, numerous studies support the notion that CD4<sup>+</sup> T cells play an indispensable role in antitumor responses. Here, we summarize and discuss the current knowledge regarding the roles of CD4<sup>+</sup> T cells in antitumor responses and immunotherapy, with a focus on the molecular and cellular mechanisms behind these observations. These new insights on CD4<sup>+</sup> T cells may pave the way to further optimize cancer immunotherapy.</p>","PeriodicalId":19003,"journal":{"name":"Molecular Carcinogenesis","volume":null,"pages":null},"PeriodicalIF":3.0000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11166516/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Carcinogenesis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/mc.23730","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/9 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
It's been long thought that CD8+ cytotoxic T cells play a major role in T cell-mediated antitumor responses, whereas CD4+ T cells merely provide some assistance to CD8+ T cells as the "helpers." In recent years, numerous studies support the notion that CD4+ T cells play an indispensable role in antitumor responses. Here, we summarize and discuss the current knowledge regarding the roles of CD4+ T cells in antitumor responses and immunotherapy, with a focus on the molecular and cellular mechanisms behind these observations. These new insights on CD4+ T cells may pave the way to further optimize cancer immunotherapy.
长期以来，人们一直认为 CD8+ 细胞毒性 T 细胞在 T 细胞介导的抗肿瘤反应中发挥着主要作用，而 CD4+ T 细胞作为 "助手 "只是为 CD8+ T 细胞提供一些帮助。近年来，大量研究支持 CD4+ T 细胞在抗肿瘤反应中发挥不可或缺的作用这一观点。在此，我们总结并讨论了目前有关 CD4+ T 细胞在抗肿瘤反应和免疫疗法中作用的知识，重点是这些观察结果背后的分子和细胞机制。这些关于 CD4+ T 细胞的新见解可能会为进一步优化癌症免疫疗法铺平道路。
期刊介绍：
Molecular Carcinogenesis publishes articles describing discoveries in basic and clinical science of the mechanisms involved in chemical-, environmental-, physical (e.g., radiation, trauma)-, infection and inflammation-associated cancer development, basic mechanisms of cancer prevention and therapy, the function of oncogenes and tumors suppressors, and the role of biomarkers for cancer risk prediction, molecular diagnosis and prognosis.
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