Association of 18F- fluorodeoxyglucose uptake with the expression of metabolism-related molecules in papillary thyroid cancer

IF 1.6 4区医学 Q2 OTORHINOLARYNGOLOGY Auris Nasus Larynx Pub Date : 2024-05-10 DOI:10.1016/j.anl.2024.04.008

Tomomi Yoshikawa, Kazuhira Endo, Makiko Moriyama-Kita, Takayoshi Ueno, Yosuke Nakanishi, Hirotomo Dochi, Daisuke Uno, Satoru Kondo, Tomokazu Yoshizaki

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Abstract

Objectives

¹⁸F-fluorodeoxyglucose positron emission tomography-computed tomography (¹⁸F-FDG-PET/CT) is a diagnostic imaging method that is based on the Warburg effect, which is the increased uptake of glucose through aerobic glycolysis in cancer cells. The diagnostic value of ¹⁸F-FDG-PET/CT for thyroid cancer is controversial. However, uptake of ¹⁸F-FDG and the corresponding maximum standardized uptake value (SUVmax) is expected to reflect the metabolic status of cancer cells. In the present study, we sought to determine the relationship between ¹⁸F-FDG uptake and tumor metabolism- associated factors.

Methods

This was a single-center retrospective study. In the present study, SUVmax was compared with the expression of hexokinase 2 (HK2), glucose transporter 1 (GLUT1), vascular endothelial growth factor (VEGF), and glutaminase 1 (GLS1) in 41 patients with thyroid cancer.

Results

GLS1 expression was found to be moderately correlated with SUVmax (p < 0.001, r = 0.51), whereas HK2 and VEGF expression were weakly correlated (p = 0.011, r = 0.28, p = 0.008, r = 0.29, respectively) and GLUT1 did not correlate with SUVmax (p = 0.62, r = 0.06).

Conclusion

Our findings suggest ¹⁸F-FDG PET/CT reflects GLS1 expression in thyroid cancer and could be used to select suitable candidates for GLS1 inhibitor treatment.

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甲状腺乳头状癌中 18F- 氟脱氧葡萄糖摄取与代谢相关分子表达的关系

目的18F-氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描（18F-FDG-PET/CT）是一种基于沃伯格效应的诊断成像方法，沃伯格效应是指癌细胞通过有氧糖酵解增加对葡萄糖的摄取。18F-FDG-PET/CT 对甲状腺癌的诊断价值还存在争议。然而，18F-FDG的摄取量和相应的最大标准化摄取值（SUVmax）有望反映癌细胞的代谢状况。在本研究中，我们试图确定 18F-FDG 摄取与肿瘤代谢相关因素之间的关系。在本研究中，41 例甲状腺癌患者的 SUVmax 与己糖激酶 2 (HK2)、葡萄糖转运体 1 (GLUT1)、血管内皮生长因子 (VEGF) 和谷氨酰胺酶 1 (GLS1) 的表达进行了比较。51），而HK2和VEGF的表达呈弱相关（分别为p = 0.011，r = 0.28，p = 0.008，r = 0.29），GLUT1与SUVmax无相关性（p = 0.62，r = 0.06）。

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来源期刊

Auris Nasus Larynx 医学-耳鼻喉科学

CiteScore

3.40

自引率

5.90%

发文量

169

审稿时长

30 days

期刊介绍： The international journal Auris Nasus Larynx provides the opportunity for rapid, carefully reviewed publications concerning the fundamental and clinical aspects of otorhinolaryngology and related fields. This includes otology, neurotology, bronchoesophagology, laryngology, rhinology, allergology, head and neck medicine and oncologic surgery, maxillofacial and plastic surgery, audiology, speech science. Original papers, short communications and original case reports can be submitted. Reviews on recent developments are invited regularly and Letters to the Editor commenting on papers or any aspect of Auris Nasus Larynx are welcomed. Founded in 1973 and previously published by the Society for Promotion of International Otorhinolaryngology, the journal is now the official English-language journal of the Oto-Rhino-Laryngological Society of Japan, Inc. The aim of its new international Editorial Board is to make Auris Nasus Larynx an international forum for high quality research and clinical sciences.