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Retrograde cricopharyngeal dysfunction: Two case reports and a literature review 逆行环咽功能障碍:2例报告及文献复习。
IF 1.5 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2026-02-01 DOI: 10.1016/j.anl.2025.12.011
Maria Angela S. Dealino , Rumi Ueha , Kyohei Horikiri , Takao Goto , Masanobu Kumada , Kenji Kondo
Retrograde cricopharyngeal dysfunction (RCPD) is a fairly recently described condition that has been gaining traction online. Majority of patients arrive at the diagnosis themselves, after undergoing numerous inconclusive investigations, indicating that widespread dissemination within the medical community remains to be seen. We present two cases, the first describes the successful medical management of a 17-year-old male who was treated with rikkunshito, a Kampo medicine, combined with mosapride, an established prokinetic agent. The second case involves a 30-year-old female with refractory symptoms who was effectively managed with endoscopic cricopharyngeal myotomy. She had previously undergone percutaneous botulinum toxin injection that initially provided temporary relief. Both patients experienced a lifelong inability to belch, and had previous unrevealing diagnostic evaluations. Prior to treatment, high-resolution manometry was performed on both patients, showing elevated basal upper esophageal sphincter (UES) pressure and absence of UES relaxation with attempted belching. These findings finally led to a diagnosis of RCPD. Increased clinician awareness of RCPD could potentially spare patients from a meandering clinical course. Alternative medicine, such as rikkunshito, could be a potential adjunct for patients unwilling to undergo procedures. For refractory cases and those intolerant of repeated injections, more extensive surgery, including cricopharyngeal myotomy, may be offered.
逆行环咽功能障碍(RCPD)是一个相当最近描述的条件,已获得牵引力在线。大多数患者在经历了许多不确定的调查之后,自己得出了诊断,这表明在医学界广泛传播仍有待观察。我们提出了两个案例,第一个描述了一个成功的医疗管理17岁的男性谁接受治疗的rikkunshito,一种柬埔寨药,联合莫沙必利,一种既定的促动力剂。第二例患者为30岁女性,症状难治性,经内镜环咽肌切开术有效治疗。她之前接受过经皮肉毒杆菌毒素注射,最初提供了暂时的缓解。这两名患者都经历了终生无法打嗝的经历,并且之前的诊断评估没有透露任何信息。治疗前,对两名患者进行了高分辨率测压,显示基底上食管括约肌(UES)压力升高,并没有UES松弛和企图打嗝。这些结果最终导致了RCPD的诊断。提高临床医生对RCPD的认识可能会使患者免于曲折的临床过程。对于不愿接受手术的患者来说,立医等替代医学可能是一种潜在的辅助手段。对于难治性病例和反复注射不耐受的患者,可以进行更广泛的手术,包括环咽肌切开术。
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引用次数: 0
Epithelial tumors of the lacrimal drainage system: A narrative review 泪道引流系统上皮性肿瘤:综述。
IF 1.5 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2026-02-01 DOI: 10.1016/j.anl.2025.12.018
Takahiro Wakasaki , Ryuji Yasumatsu
In this review, we aimed to provide a comprehensive and up-to-date overview of epithelial tumors of the lacrimal drainage system (LDS)—rare but clinically significant entities that are often misdiagnosed as benign obstructions—by integrating recent evidence regarding epidemiology, clinical manifestations, diagnostic approaches, histopathological and molecular diversity as well as warning signs and imaging and biopsy strategies. According to the available data, squamous cell carcinoma is the predominant subtype, including both human papillomavirus (HPV)-positive non-keratinizing (transitional-type) variants with p16 overexpression and phosphatidylinositol 3-kinase, catalytic subunit alpha (PIK3CA)/fibroblast growth factor receptor 3 (FGFR3) alterations and HPV-negative keratinizing forms with tumor protein p53 (TP53) mutations. Management emphasizes complete en bloc resection aiming for negative margins supported by adjuvant radiotherapy. Organ-preserving chemoradiotherapy may be feasible in p16-positive cases, whereas proton or carbon-ion therapy has been shown to allow for precise dosing at anatomically constrained sites. Prognosis depends mainly on extent, margin status, perineural invasion, nodal involvement, histological subtype, and HPV status. Earlier recognition through awareness of “red flags” and standardized work-ups can significantly improve outcomes by reducing resection extent and morbidity risk. The integration of HPV status assessment and molecular profiling now allows biologically informed risk stratification and opens up new avenues for targeted and immune therapies, and proton and carbon-ion radiotherapies extend curative options to anatomically constrained regions. Important future research directions include designing molecularly informed therapeutic trials and prioritizing the development and establishment of standardized diagnostic frameworks and multicenter registries.
在这篇综述中,我们旨在通过整合流行病学、临床表现、诊断方法、组织病理学和分子多样性、警告信号、成像和活检策略等方面的最新证据,对泪道引流系统(LDS)上皮性肿瘤(罕见但临床上重要的实体,经常被误诊为良性梗阻)进行全面和最新的概述。根据现有数据,鳞状细胞癌是主要亚型,包括人乳头瘤病毒(HPV)阳性的非角化(过渡型)变异,p16过表达,磷脂酰肌醇3-激酶,催化亚单位α (PIK3CA)/成纤维细胞生长因子受体3 (FGFR3)改变,HPV阴性的角化形式,肿瘤蛋白p53 (TP53)突变。治疗强调以阴性切缘为目标的全组切除,并辅以辅助放疗。在p16阳性病例中,保留器官的放化疗可能是可行的,而质子或碳离子治疗已被证明可以在解剖受限的部位精确给药。预后主要取决于范围、边缘状况、神经周围浸润、淋巴结受累、组织学亚型和HPV状态。通过意识到“危险信号”和标准化的检查,早期识别可以通过减少切除范围和发病率风险显着改善结果。HPV状态评估和分子谱的整合现在允许生物学知情的风险分层,并为靶向和免疫治疗开辟了新的途径,质子和碳离子放疗将治疗选择扩展到解剖学受限的区域。未来重要的研究方向包括设计分子知情的治疗试验,优先发展和建立标准化诊断框架和多中心注册。
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引用次数: 0
Comments on “Physical therapy for peripheral facial palsy: A systematic review and meta-analysis” “周围性面瘫的物理治疗:系统回顾和荟萃分析”评论。
IF 1.5 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2026-02-01 DOI: 10.1016/j.anl.2025.11.001
Run-cheng Wang , Li-hua Xuan
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引用次数: 0
Authors’ reply: Comments on “Physical therapy for peripheral facial palsy: A systematic review and meta-analysis” 作者回复:对“周围性面瘫的物理治疗:一个系统回顾和荟萃分析”的评论。
IF 1.5 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2026-02-01 DOI: 10.1016/j.anl.2025.11.002
Haruki Nakano , Takashi Fujiwara , Yasushi Tsujimoto , Naohito Morishima , Takashi Kasahara , Misato Ameya , Keita Tachibana , Shota Sanada , Saori Toufukuji , Naohito Hato
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引用次数: 0
Removal of submandibular hilar stones using a sialendoscope and a high-definition endoscope: Our experience and outcomes 使用鼻内窥镜和高清晰度内窥镜去除下颌门下结石:我们的经验和结果。
IF 1.5 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2026-02-01 DOI: 10.1016/j.anl.2025.12.019
Takahiro Suzuki, Teruyuki Sato, Yutaka Tateda, Nobuo Ohta

Objective

Sialendoscopy is a minimally invasive approach that enables better visualisation of the salivary ductal system, as well as treatment of salivary stones. A high-definition endoscope (HDE) is excellent for observing deep areas of the oral cavity. We have used these two types of endoscopes for the treatment of submandibular hilar stones. The aim of this study was to review the treatment outcomes of sialendoscopy with/without an HDE for submandibular hilar stones in our patient population.

Methods

We conducted a retrospective review of 74 cases of submandibular hilar stones that were treated at our hospital. The following factors were investigated in these cases: age, gender, stone size, removal method, success rates, postoperative complications, and rate of improvement in symptoms postoperatively. Regarding the removal method, stone retrieval via the Wharton's duct using the sialendoscope was classified as sialendoscopy alone, while endoscopic stone removal using a transoral approach with the assistance of the sialendoscope was classified as the combined approach.

Results

Median patient age was 35.5 years. There were 30 males and 44 females. Stone size ranged from 1 to 18 mm, with a median size of 6 mm. The stones were successfully removed transorally in 71 (96 %) of the 74 patients. Stone retrieval was performed by sialendoscopy alone in 10 cases, while a combined approach was required in the remaining 61 cases. Of these 61 cases, the stone location could be identified under a magnified view with HDE in 46 cases. In the remaining 15 cases, the stone location was identified by the simultaneous use of a sialendoscope and HDE. Regarding postoperative complications, ranula, transient lingual nerve paralysis and neck abscess were observed in three (4 %), two (2.7 %) and one (1.3 %) patient, respectively. In terms of the rate of symptom improvement, 67 of the 71 cases (94 %) in whom transoral stone removal was successful showed complete resolution of symptoms, while four cases (6 %) exhibited mild symptoms of obstruction.

Conclusion

Sialendoscopy is an effective method for removing submandibular hilar stones, with a low incidence of postoperative complications. Using an HDE during transoral surgery enhances its efficacy by aiding precise localisation of the stone, facilitating its removal and detecting residual fragments or stones.
目的:唾液内镜是一种微创的方法,可以更好地观察唾液导管系统,以及治疗唾液结石。高清晰度内窥镜(HDE)非常适合观察口腔深处。我们已经使用这两种内窥镜治疗下颌骨门下结石。本研究的目的是回顾在我们的患者群体中,有/没有HDE的咽镜检查治疗下颌骨门结石的结果。方法:对我院收治的74例下颌骨门结石进行回顾性分析。在这些病例中,我们调查了以下因素:年龄、性别、结石大小、取出方法、成功率、术后并发症和术后症状改善率。在取石方式上,经沃顿氏管鼻内窥镜取石归为单独鼻内窥镜,经口鼻内窥镜联合取石归为联合取石。结果:患者中位年龄为35.5岁。男性30人,女性44人。石头的大小从1到18毫米不等,中间大小为6毫米。74例患者中有71例(96%)经口成功取出结石。10例患者单独行咽镜取石,其余61例需要联合取石。在这61例中,有46例在HDE的放大视图下可以确定结石的位置。在其余15例患者中,通过同时使用鼻内窥镜和HDE来确定结石的位置。术后并发症中出现ranula 3例(4%),一过性舌神经麻痹2例(2.7%),颈部脓肿1例(1.3%)。在症状改善率方面,71例经口结石取出成功的患者中67例(94%)症状完全缓解,4例(6%)出现轻度梗阻症状。结论:鼻内镜是一种有效的下颌门下结石清除方法,术后并发症发生率低。在经口手术中使用HDE通过帮助结石的精确定位,促进其清除和检测残余碎片或结石来提高其疗效。
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引用次数: 0
Evaluation of ear structures on fetal MRI: A comparative analysis at 1.5-T and 3-T 胎儿MRI对耳部结构的评价:1.5 t和3 t的比较分析。
IF 1.5 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2026-02-01 DOI: 10.1016/j.anl.2025.12.017
Said Sonmez , Omer Orak , Sumeyye Guzeloglu Orak , Edanur Karapinar , Mehmet Barburoglu , Tugba Sarac Sivrikoz , Tuğba Kalaycı , Umit Tuzun , Mehmet Celik , Beldan Polat , Yahya Guldiken , Derya Umit Talas , Kadir Serkan Orhan

Objectives

To compare the visualization of fetal ear structures on 1.5-Tesla (T) and 3-T fetal MRI (feMRI) using a staging system, and to measure cochlear height (CH) at 3-T.

Methods

Between 2009–2024, 147 feMRI examinations were retrospectively evaluated; after excluding 25 suboptimal scans, 122 studies were analyzed (1.5-T = 80; 3-T = 42). The cochlea, vestibule–semicircular canals (V-SCC), middle ear–ossicular chain (ME-OC), and external auditory canal (EAC) were systematically staged by a blinded neuroradiologist. CH was measured on 3-T. Categorical and group comparisons, correlation and ROC analysis were performed.

Results

Mean gestational week (GW) was 29.1 ± 3.7 weeks with no between-group difference (p = 0.101). Staging scores were higher at 3-T for the cochlea and V-SCC (both p < 0.001) and for ME-OC (p = 0.019), with no difference for EAC (p = 0.317). At 3-T, cochlear turns were identifiable in 83.3%, the lateral semicircular canal in 61.9%, and ossicles in 73.8%; at least one EAC was visualized in 71.4%. GW correlated with V-SCC (rₛ=0.220, p = 0.015) and EAC (rₛ=0.330, p < 0.001). ROC analysis identified 29.5 GW as the optimal cutoff for EAC visualization (AUC=0.718; 95% CI, 0.626–0.809; sensitivity, 57.3%; specificity, 75.0%; p < 0.001). At 3-T, CH averaged 5.17 ± 0.53 mm and showed no correlation with GW (r = 0.041, p = 0.794).

Conclusion

Compared with 1.5-T, 3-T feMRI provides superior visualization of inner and middle ear structures, with similar EAC performance. In suspected anomalies, a focused ear assessment within feMRI improves prenatal ear evaluation, alongside ultrasonography.
目的:采用分期系统比较1.5-Tesla (T)和3-T胎儿MRI (feMRI)上胎儿耳廓结构的显示,并测量3-T时耳蜗高度(CH)。方法:回顾性评价2009-2024年间147例feMRI检查;在排除了25次次优扫描后,分析了122项研究(1.5-T = 80; 3-T = 42)。耳蜗、前庭-半规管(V-SCC)、中耳-听骨链(ME-OC)和外耳道(EAC)由盲法神经放射学家系统分期。用3-T法测定CH。进行分类比较、分组比较、相关分析和ROC分析。结果:平均妊娠周(GW)为29.1±3.7周,组间差异无统计学意义(p = 0.101)。耳蜗和V-SCC的3-T分期评分较高(p < 0.001), ME-OC分期评分较高(p = 0.019), EAC分期评分无差异(p = 0.317)。3-T时,耳蜗转弯占83.3%,外侧半规管占61.9%,听骨占73.8%;71.4%的患者至少有一例EAC可见。GW与V-SCC (rₛ=0.220,p = 0.015)、EAC (rₛ=0.330,p < 0.001)相关。ROC分析确定29.5 GW为EAC可视化的最佳临界值(AUC=0.718; 95% CI, 0.626-0.809;敏感性57.3%;特异性75.0%;p < 0.001)。在3-T时,CH平均为5.17±0.53 mm,与GW无相关性(r = 0.041, p = 0.794)。结论:与1.5-T相比,3-T feMRI能更好地显示内耳和中耳结构,具有相似的EAC性能。在可疑的异常中,在feMRI内进行集中的耳部评估可以改善产前耳部评估,同时进行超声检查。
{"title":"Evaluation of ear structures on fetal MRI: A comparative analysis at 1.5-T and 3-T","authors":"Said Sonmez ,&nbsp;Omer Orak ,&nbsp;Sumeyye Guzeloglu Orak ,&nbsp;Edanur Karapinar ,&nbsp;Mehmet Barburoglu ,&nbsp;Tugba Sarac Sivrikoz ,&nbsp;Tuğba Kalaycı ,&nbsp;Umit Tuzun ,&nbsp;Mehmet Celik ,&nbsp;Beldan Polat ,&nbsp;Yahya Guldiken ,&nbsp;Derya Umit Talas ,&nbsp;Kadir Serkan Orhan","doi":"10.1016/j.anl.2025.12.017","DOIUrl":"10.1016/j.anl.2025.12.017","url":null,"abstract":"<div><h3>Objectives</h3><div>To compare the visualization of fetal ear structures on 1.5-Tesla (T) and 3-T fetal MRI (feMRI) using a staging system, and to measure cochlear height (CH) at 3-T.</div></div><div><h3>Methods</h3><div>Between 2009–2024, 147 feMRI examinations were retrospectively evaluated; after excluding 25 suboptimal scans, 122 studies were analyzed (1.5-<em>T</em> = 80; 3-<em>T</em> = 42). The cochlea, vestibule–semicircular canals (V-SCC), middle ear–ossicular chain (ME-OC), and external auditory canal (EAC) were systematically staged by a blinded neuroradiologist. CH was measured on 3-T. Categorical and group comparisons, correlation and ROC analysis were performed.</div></div><div><h3>Results</h3><div>Mean gestational week (GW) was 29.1 ± 3.7 weeks with no between-group difference (<em>p</em> = 0.101). Staging scores were higher at 3-T for the cochlea and V-SCC (both <em>p</em> &lt; 0.001) and for ME-OC (<em>p</em> = 0.019), with no difference for EAC (<em>p</em> = 0.317). At 3-T, cochlear turns were identifiable in 83.3%, the lateral semicircular canal in 61.9%, and ossicles in 73.8%; at least one EAC was visualized in 71.4%. GW correlated with V-SCC (rₛ=0.220, <em>p</em> = 0.015) and EAC (rₛ=0.330, <em>p</em> &lt; 0.001). ROC analysis identified 29.5 GW as the optimal cutoff for EAC visualization (AUC=0.718; 95% CI, 0.626–0.809; sensitivity, 57.3%; specificity, 75.0%; <em>p</em> &lt; 0.001). At 3-T, CH averaged 5.17 ± 0.53 mm and showed no correlation with GW (<em>r</em> = 0.041, <em>p</em> = 0.794).</div></div><div><h3>Conclusion</h3><div>Compared with 1.5-T, 3-T feMRI provides superior visualization of inner and middle ear structures, with similar EAC performance. In suspected anomalies, a focused ear assessment within feMRI improves prenatal ear evaluation, alongside ultrasonography.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"53 1","pages":"Pages 137-145"},"PeriodicalIF":1.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145945684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human otoacariasis by Amblyomma testudinarium identified with 16S rRNA gene sequencing 用16S rRNA基因测序鉴定人耳螨病。
IF 1.5 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2026-02-01 DOI: 10.1016/j.anl.2025.12.013
Mika Nakano , Tomokatsu Udagawa , Kayoko Yamaji , Munenari Itoh , Hirotaka Kanuka , Mamoru Yoshikawa
Human otoacariasis caused by tick bites in the external auditory canal is rarely reported in Japan, despite the recent increase in the movement of wild animals, known hosts of ticks into human living areas due to global warming. We report a case of human otoacariasis caused by Amblyomma testudinarium, genetically identified using 16S rRNA gene sequencing. A 43-year-old man presented to an urban hospital in Tokyo with left-sided otalgia. An endoscopic examination revealed a tick anchored to the skin of the external auditory canal, which showed erythema and swelling. Initial attempts to remove the tick were unsuccessful because it was firmly attached by a cement-like substance. Thereafter, the patient was treated with antibiotic and corticosteroid ear drops, which resulted in tick death and a reduction in inflammation. The shrunken tick was then successfully removed, and polymerase chain reaction analysis confirmed its species as Amblyomma testudinarium. Although a stereomicroscopic examination revealed a small defect in the tick mouthparts, no symptoms were observed during a follow-up period of more than one month. This case highlights the clinical importance of accurate tick species identification, even in urban environment, due to the potential risk of tick-borne diseases such as severe fever with thrombocytopenia syndrome.
尽管由于全球变暖,野生动物(已知的蜱虫宿主)进入人类生活区的活动最近有所增加,但日本很少报道由外耳道蜱虫叮咬引起的人类耳虫病。我们报告一例人类耳螨病引起的无瘤鼠,遗传鉴定使用16S rRNA基因测序。一名43岁男子因左侧耳痛被送往东京一家城市医院。内窥镜检查发现外耳道皮肤上有一只蜱虫,并出现红斑和肿胀。最初的尝试没有成功,因为它被一种类似水泥的物质牢牢地附着在上面。此后,患者接受抗生素和皮质类固醇滴耳液治疗,导致蜱虫死亡,炎症减轻。然后成功地去除萎缩的蜱虫,聚合酶链反应分析证实它的物种为斑点钝瘤。虽然体视显微镜检查发现蜱口器有小缺陷,但在一个多月的随访期间未观察到任何症状。该病例强调了准确识别蜱虫种类的临床重要性,即使在城市环境中也是如此,因为蜱虫传播疾病(如严重发热伴血小板减少综合征)的潜在风险。
{"title":"Human otoacariasis by Amblyomma testudinarium identified with 16S rRNA gene sequencing","authors":"Mika Nakano ,&nbsp;Tomokatsu Udagawa ,&nbsp;Kayoko Yamaji ,&nbsp;Munenari Itoh ,&nbsp;Hirotaka Kanuka ,&nbsp;Mamoru Yoshikawa","doi":"10.1016/j.anl.2025.12.013","DOIUrl":"10.1016/j.anl.2025.12.013","url":null,"abstract":"<div><div>Human otoacariasis caused by tick bites in the external auditory canal is rarely reported in Japan, despite the recent increase in the movement of wild animals, known hosts of ticks into human living areas due to global warming. We report a case of human otoacariasis caused by <em>Amblyomma testudinarium</em>, genetically identified using 16S rRNA gene sequencing. A 43-year-old man presented to an urban hospital in Tokyo with left-sided otalgia. An endoscopic examination revealed a tick anchored to the skin of the external auditory canal, which showed erythema and swelling. Initial attempts to remove the tick were unsuccessful because it was firmly attached by a cement-like substance. Thereafter, the patient was treated with antibiotic and corticosteroid ear drops, which resulted in tick death and a reduction in inflammation. The shrunken tick was then successfully removed, and polymerase chain reaction analysis confirmed its species as <em>Amblyomma testudinarium</em>. Although a stereomicroscopic examination revealed a small defect in the tick mouthparts, no symptoms were observed during a follow-up period of more than one month. This case highlights the clinical importance of accurate tick species identification, even in urban environment, due to the potential risk of tick-borne diseases such as severe fever with thrombocytopenia syndrome.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"53 1","pages":"Pages 157-160"},"PeriodicalIF":1.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Survival analysis of initially inserted Kobayashi plugs in patulous Eustachian tube: A retrospective study of 297 ears 初步置入Kobayashi耳塞于扩张性耳咽管的生存分析:回顾性研究297耳
IF 1.5 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2026-01-31 DOI: 10.1016/j.anl.2026.01.005
Takeshi Oshima , Marin Yoshida , Hidetoshi Oshima , Hideshi Shindo , Ryoji Hirai

Objectives

Kobayashi Plug Surgery (KPS) is widely performed in Japan for refractory patulous Eustachian tube (PET). However, the duration of retention and long-term stability of the initially inserted plug have not been fully evaluated. Therefore, this study aimed to analyze plug retention (plug survival) and assess the validity of preoperative sonotubometry (ST) probe tone levels as an indicator for plug size selection.

Methods

A retrospective review was conducted of 237 patients (297 ears) who underwent initial KPS between January 2020 and August 2025. Ears were categorized by initial plug size: group A (size 3), group B (size 4), and group C (size ≥5). Plug removal or replacement (upsizing or downsizing) was defined as an event, and survival was analyzed using the Kaplan–Meier method. Multivariate Cox regression and Weibull parametric models were applied to identify predictors of plug survival. Preoperative ST values were compared among groups and correlated with postoperative outcomes.

Results

At initial surgery, size 4 plugs were most frequently used (61%). During follow-up, 42 events occurred (14.1%). Kaplan–Meier analysis showed a mean survival time of 900.6 days and a 75% survival time of 1076 days, with no significant differences among groups (log-rank test, p = 0.61). Weibull analysis revealed a shape parameter (β) <1, indicating high early postoperative risk followed by long-term stability. Cox regression showed no significant effects of plug size, age, or ST values on survival. Among the 181 ears treated with a size 4 plug, 96 were followed for more than one year without events, and 92 of these were classified as long-term favorable cases. Preoperative ST values differed among size groups but did not predict postoperative course, particularly in size 4 cases.

Conclusion

KPS demonstrated durable long-term effectiveness, with most plugs remaining stable beyond the early postoperative period. While ST levels guide initial size selection, long-term outcomes appear influenced by additional anatomical and clinical factors, underscoring the need for complementary diagnostics and individualized follow-up.
目的小林塞手术在日本广泛应用于难治性扩张性咽鼓管(PET)的治疗。然而,最初插入的桥塞的保留时间和长期稳定性尚未得到充分评估。因此,本研究旨在分析耳塞保留(耳塞存活),并评估术前超声管测音(ST)探头音调水平作为耳塞尺寸选择指标的有效性。方法回顾性分析2020年1月至2025年8月期间接受首次KPS治疗的237例患者(297耳)。耳塞按初始尺寸分为A组(尺寸3)、B组(尺寸4)和C组(尺寸≥5)。将堵头移除或更换(放大或缩小)定义为一个事件,并使用Kaplan-Meier方法分析存活情况。多变量Cox回归和威布尔参数模型用于确定堵塞存活的预测因子。组间比较术前ST值并与术后预后相关。结果首次手术时,最常使用4号桥塞(61%)。随访期间共发生42例(14.1%)。Kaplan-Meier分析显示,平均生存时间为9000.6天,75%的生存时间为1076天,组间差异无统计学意义(log-rank检验,p = 0.61)。Weibull分析显示形状参数(β) <1,表明术后早期风险高,随后长期稳定。Cox回归显示栓子大小、年龄或ST值对生存率无显著影响。在接受4号耳塞治疗的181只耳朵中,96只耳朵随访超过一年没有发生任何事件,其中92只耳朵被归类为长期有利病例。术前ST值在大小组之间存在差异,但不能预测术后病程,特别是在4大小的病例中。结论kps具有持久的长期疗效,大多数桥塞在术后早期保持稳定。虽然ST水平指导了最初的大小选择,但长期结果似乎受到其他解剖学和临床因素的影响,强调了补充诊断和个性化随访的必要性。
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引用次数: 0
Clinical relevance of the new classification for mastoid progression in the staging and classification criteria for middle ear cholesteatoma proposed by the Japan Otological society. 日本耳科学会提出的中耳胆脂瘤分期及分类标准中乳突进展新分类的临床意义
IF 1.5 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2026-01-31 DOI: 10.1016/j.anl.2026.01.011
Yuka Morita, Tatsuya Yamagishi, Masahiro Takahashi, Yasuhiro Tanaka, Kuniyuki Takahashi, Tsukasa Ito, Yusuke Ayani, Natsumi Uehara, Manabu Komori, Yoshihiko Hiraga, Naoki Ohishi, Akira Ganaha, Yutaka Yamamoto, Shin-Ichi Haginomori, Tetsuya Tono

Objective: To evaluate the clinical significance of the newly proposed Japan Otological Society (JOS) classification for mastoid extension (M subdivision: M0, M1, M2) in patients with middle ear cholesteatoma.

Methods: Patients with newly diagnosed middle ear cholesteatoma who underwent primary surgery at participating institutions between January 2021 and December 2022 were included. The extent of disease was classified according to the 2015 JOS staging system, with mastoid extension further subdivided into M0 (no mastoid extension), M1 (limited to the antrum), and M2 (extending beyond the antrum or the lateral SCC).

Results: A total of 527 patients from 11 institutions were registered. Among them, 332 ears (63%) had pars flaccida cholesteatoma, 59 (11%) had pars tensa cholesteatoma, 69 (13%) had congenital cholesteatoma, 40 (8%) had cholesteatoma secondary to pars tensa perforation, and 27 (5%) were unclassifiable. Staging distribution included 112 ears (22%) classified as Stage I, 350 (66%) as Stage II, and 65 (12%) as Stage III; none were Stage IV. Mastoid extension was classified as M0 in 245 ears (46.2%), M1 in 123 (23.8%), and M2 in 159 (30.0%). Mastoid involvement was significantly more common in pars flaccida cholesteatoma, and higher M subdivision correlated with higher JOS stage. The transcanal atticotomy was most often used for M0 cases, whereas canal wall up and canal wall down tympanoplasty predominated in M1 and M2 groups. The use of transcanal endoscopic ear surgery decreased significantly with greater mastoid extension. No significant differences in recurrence rates or postoperative hearing outcomes were observed among the M subdivisions.

Conclusion: The JOS classification of mastoid extension provides a practical and meaningful framework for assessing middle ear cholesteatoma. Although it did not affect short-term outcomes, the M subdivision offers useful guidance for surgical planning and reflects disease extent more precisely.

目的:评价新提出的日本耳科学会(JOS)乳突延伸分型(M细分:M0、M1、M2)对中耳胆脂瘤患者的临床意义。方法:纳入2021年1月至2022年12月在参与机构行初级手术的新诊断中耳胆脂瘤患者。根据2015年JOS分期系统对疾病程度进行分类,乳突扩张进一步细分为M0(无乳突扩张)、M1(局限于上颌窦腔)和M2(超出上颌窦腔或外侧SCC)。结果:共纳入11所医院527例患者。其中,松弛部胆脂瘤332例(63%),张力部胆脂瘤59例(11%),先天性胆脂瘤69例(13%),张力部穿孔继发胆脂瘤40例(8%),无法分型27例(5%)。分期分布:ⅰ期112例(22%),ⅱ期350例(66%),ⅲ期65例(12%);乳突延伸245例(46.2%)为M0, 123例(23.8%)为M1, 159例(30.0%)为M2。乳突受累在松弛部胆脂瘤中更为常见,较高的M细分与较高的JOS分期相关。M0组多采用经鼻心室切开术,而M1组和M2组以鼓室上壁和下壁成形术为主。经鼻内窥镜耳部手术的使用随着乳突的扩大而显著减少。在复发率和术后听力结果方面,M组间无显著差异。结论:乳突膨出的JOS分型为中耳胆脂瘤的诊断提供了一个实用而有意义的框架。虽然它不影响短期预后,但M细分为手术计划提供了有用的指导,并更准确地反映了疾病的程度。
{"title":"Clinical relevance of the new classification for mastoid progression in the staging and classification criteria for middle ear cholesteatoma proposed by the Japan Otological society.","authors":"Yuka Morita, Tatsuya Yamagishi, Masahiro Takahashi, Yasuhiro Tanaka, Kuniyuki Takahashi, Tsukasa Ito, Yusuke Ayani, Natsumi Uehara, Manabu Komori, Yoshihiko Hiraga, Naoki Ohishi, Akira Ganaha, Yutaka Yamamoto, Shin-Ichi Haginomori, Tetsuya Tono","doi":"10.1016/j.anl.2026.01.011","DOIUrl":"https://doi.org/10.1016/j.anl.2026.01.011","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical significance of the newly proposed Japan Otological Society (JOS) classification for mastoid extension (M subdivision: M0, M1, M2) in patients with middle ear cholesteatoma.</p><p><strong>Methods: </strong>Patients with newly diagnosed middle ear cholesteatoma who underwent primary surgery at participating institutions between January 2021 and December 2022 were included. The extent of disease was classified according to the 2015 JOS staging system, with mastoid extension further subdivided into M0 (no mastoid extension), M1 (limited to the antrum), and M2 (extending beyond the antrum or the lateral SCC).</p><p><strong>Results: </strong>A total of 527 patients from 11 institutions were registered. Among them, 332 ears (63%) had pars flaccida cholesteatoma, 59 (11%) had pars tensa cholesteatoma, 69 (13%) had congenital cholesteatoma, 40 (8%) had cholesteatoma secondary to pars tensa perforation, and 27 (5%) were unclassifiable. Staging distribution included 112 ears (22%) classified as Stage I, 350 (66%) as Stage II, and 65 (12%) as Stage III; none were Stage IV. Mastoid extension was classified as M0 in 245 ears (46.2%), M1 in 123 (23.8%), and M2 in 159 (30.0%). Mastoid involvement was significantly more common in pars flaccida cholesteatoma, and higher M subdivision correlated with higher JOS stage. The transcanal atticotomy was most often used for M0 cases, whereas canal wall up and canal wall down tympanoplasty predominated in M1 and M2 groups. The use of transcanal endoscopic ear surgery decreased significantly with greater mastoid extension. No significant differences in recurrence rates or postoperative hearing outcomes were observed among the M subdivisions.</p><p><strong>Conclusion: </strong>The JOS classification of mastoid extension provides a practical and meaningful framework for assessing middle ear cholesteatoma. Although it did not affect short-term outcomes, the M subdivision offers useful guidance for surgical planning and reflects disease extent more precisely.</p>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"53 2","pages":"239-244"},"PeriodicalIF":1.5,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146101078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metachronous development of bilateral external auditory canal cancer 双侧外耳道癌的异时性发展
IF 1.5 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2026-01-30 DOI: 10.1016/j.anl.2026.01.008
Hiroaki Masuda , Kazushi Fujiyama , Sanami Azuma , Toshiyuki Mukai , Anjin Mori , Sadahiro Kishishita , Sakiko Miura , Teppei Morikawa , Kazunari Nakao
Cancer originating from the external auditory canal (EAC) is rare, which precludes a clear understanding of the disease and its management approaches. We present an extremely rare case of bilateral auditory canal carcinoma that occurred heterochronously. Bilateral treatments resulted in good disease control and EAC structure preservation, which could accommodate various hearing aid options after cancer treatment. While disease control is the most crucial aspect to be considered when choosing a treatment of EAC cancer, one should also consider potential hearing ability in patients post-surgery, particularly in those with bilateral lesions, as it greatly influences the quality of life.
起源于外耳道(EAC)的癌症是罕见的,这妨碍了对疾病及其治疗方法的明确认识。我们报告一例极为罕见的双侧听道癌异时发生的病例。双侧治疗可以很好地控制疾病,保留EAC结构,可以适应癌症治疗后的各种助听器选择。虽然疾病控制是选择EAC癌症治疗方案时要考虑的最重要方面,但也应考虑术后患者的潜在听力能力,特别是双侧病变患者,因为这极大地影响了生活质量。
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Auris Nasus Larynx
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