Auris Nasus Larynx最新文献

{"title":"Response to \"Multi-institutional studies to enhance the understanding of primary salivary gland squamous cell carcinoma\".","authors":"Takumi Kumai, Ryosuke Sato, Miki Takahara","doi":"10.1016/j.anl.2025.02.005","DOIUrl":"https://doi.org/10.1016/j.anl.2025.02.005","url":null,"abstract":"","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Over three-year outcomes of Bonebridge implantation in children and adolescents with congenital bilateral conductive hearing loss","authors":"Yuan Wang,&nbsp;Jikai Zhu,&nbsp;Yujie Liu,&nbsp;Danni Wang,&nbsp;Shouqin Zhao","doi":"10.1016/j.anl.2025.02.007","DOIUrl":"10.1016/j.anl.2025.02.007","url":null,"abstract":"<div><h3>Objective</h3><div>Investigation of the long-term performance and safety of Bonebridge in children and adolescents with congenital bilateral conductive hearing loss (BCHL) over 3 years post-implantation.</div></div><div><h3>Methods</h3><div>20 children and adolescents diagnosed with congenital BCHL underwent Bonebridge implantation over 36 months were enrolled. Preoperative and final follow-up pure-tone average (PTA) results were recorded, and whether postoperative complications occurred. All patients tested under two listening conditions: (1) unaided, (2) Bonebridge aided. The speech reception thresholds (SRTs), speech discrimination scores (SDSs) and sound field hearing thresholds (SFHTs) were measured. The mean absolute error (MAE) of sound source localization was calculated to assess the sound localization accuracy.</div></div><div><h3>Results</h3><div>The median age of 20 patients underwent Bonebridge implantation was 9 years old, and follow-up time was 55 months. There were no difference in PTA air conduction and bone conduction between preoperative with postoperative. The performance in SRTs, SDSs and SFHTs were significantly higher in the Bonebridge aided condition than that in the unaided. Concerning sound source localization, the accuracy of localization exhibited a sharp decline when using a single side Bonebridge. However, their sound localization abilities on the Bonebridge implantation same side remained unaffected. One patient had implant exposure, and completed the experiment with the exposed Bonebridge, then underwent a revision surgery. All other complications were resolved by conservative treatment.</div></div><div><h3>Conclusion</h3><div>The performance and safety of Bonebridge were established in children and adolescents with congenital BCHL over 3 years post-implantation.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 3","pages":"Pages 207-215"},"PeriodicalIF":1.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-institutional studies to enhance the understanding of primary salivary gland squamous cell carcinoma.","authors":"Lazzeroni Matteo, Maniaci Antonino, Lentini Mario, Cristina Amaglio, Capaccio Pasquale","doi":"10.1016/j.anl.2025.02.006","DOIUrl":"https://doi.org/10.1016/j.anl.2025.02.006","url":null,"abstract":"","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A questionnaire survey for an orbital blowout fracture medical examination by Japanese otorhinolaryngologists","authors":"Yasushi Samukawa ,&nbsp;Kosuke Akiyama ,&nbsp;Kosuke Takabayashi ,&nbsp;Hiroshi Hoshikawa","doi":"10.1016/j.anl.2025.02.004","DOIUrl":"10.1016/j.anl.2025.02.004","url":null,"abstract":"<div><h3>Objective</h3><div>The status of orbital blowout fracture (BOF) management remains unclear due to the lack of standardized guidelines and limited data from individual facilities. Therefore, the present study aimed to assess current practices for diagnosing, treating, and evaluating BOF among Japanese otorhinolaryngologists.</div></div><div><h3>Methods</h3><div>A web-based questionnaire was distributed to 1,800 members of the Japanese Rhinologic Society and 621 designated clinical training hospitals. The survey was conducted between May 23 and August 31, 2024, and gathered information on diagnostic procedures, treatment approaches, post-operative evaluations, and complications associated with BOF surgery. Responses from 318 facilities, excluding duplicates, were analyzed.</div></div><div><h3>Results</h3><div>Out of 318 facilities, BOF surgery was performed in 129 by otolaryngologists. Computed tomography (CT) was the primary diagnostic modality used pre-operatively at all facilities, with Hess screen tests also being widely used (82.1 %). However, post-operative CT usage was significantly lower (55.8 %). Surgical indications were often decided within 1–2 weeks post-injury in most facilities. The most common complication was infra-orbital nerve disorder (19.4 %), followed by nasal bleeding (10.1 %) and anterior superior alveolar nerve disorder (9.3 %). An endoscopic endonasal approach was commonly performed for medial wall fractures, while a combined intra-/extra-nasal technique was frequently conducted for inferior wall fractures. Rigid reconstruction was performed on approximately 50 % of cases, using materials such as absorbable plates and autologous bone.</div></div><div><h3>Conclusion</h3><div>The present study highlighted significant variations in BOF management among facilities, indicating the need for standardization in evaluation methods and post-operative follow-up.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 3","pages":"Pages 201-206"},"PeriodicalIF":1.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143455135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The long-term stability after regeneration therapy for tympanic membrane perforation","authors":"Masahiro Takahashi,&nbsp;Shin-ichiro Oka,&nbsp;Sakiko Furutate,&nbsp;Syogo Oyamada,&nbsp;Satoshi Iwasaki","doi":"10.1016/j.anl.2025.02.003","DOIUrl":"10.1016/j.anl.2025.02.003","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the long-term stability of regenerative treatment for tympanic membrane perforation (TMP) using gelatin sponge, basic fibroblast growth factor (bFGF) and fibrin glue in a population with TMP closure.</div></div><div><h3>Material and methods</h3><div>Treatment could be performed up to four times until perforation closure was achieved. Cases in which perforation closure was finally achieved underwent 1 year of follow-up observation. Perforation closure rate was assessed more than 1 year after initial perforation closure, cases of reperforation were examined, and complications were considered.</div></div><div><h3>Results</h3><div>Postoperative observation after 1 year showed complete closure of the TM remained in 45 of the 54 cases (83.3 %). A high rate of perforation closure was thus maintained. Apart from five cases with small perforations, no complications such as dizziness, ear discharge, or cholesteatoma formation were observed.</div></div><div><h3>Conclusion</h3><div>These findings suggest the long-term stability of regeneration therapy using gelatin sponge, bFGF, and fibrin glue. This regeneration therapy appears feasible and safe, with a closure rate of TMP after this regeneration therapy equivalent to that of traditional tympanoplasty and myringoplasty.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 2","pages":"Pages 195-199"},"PeriodicalIF":1.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photoimmunotherapy for head and neck cancer: A systematic review","authors":"Isaku Okamoto","doi":"10.1016/j.anl.2025.01.005","DOIUrl":"10.1016/j.anl.2025.01.005","url":null,"abstract":"<div><div>Photoimmunotherapy is a new cancer treatment that uses cetuximab sarotalocan sodium, a conjugate of cetuximab and the light activatable dye, IR700, and red light at a wavelength of 690 nm.</div><div>In Japan, photoimmunotherapy for “unresectable locally advanced or locally recurrent head and neck cancer” has been covered by insurance since 2021. Although presently approved only for head and neck cancer, photoimmunotherapy is an important technology in the future of various cancer treatments. Photoimmunotherapy is an important technology for the future of various cancer treatments, and it is essential to strive for the development and widespread use of photoimmunotherapy in clinical practice.</div><div>In this review, we will explain the mechanism of photoimmunotherapy, treatment cases, clinical trial data, reports from real world data in Japan, and future issues and prospects as seen in actual clinical practice.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 2","pages":"Pages 186-194"},"PeriodicalIF":1.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for distant metastasis in papillary thyroid carcinoma: Association with lateral lymph node metastasis","authors":"Masataka Nakamura ,&nbsp;Nobuya Monden ,&nbsp;Tomonori Terada ,&nbsp;Nobuhiro Uwa ,&nbsp;Yuichiro Shinoda ,&nbsp;Junko Fukutake ,&nbsp;Hiroshi Kono ,&nbsp;Takehito Kishino ,&nbsp;Naoki Akisada ,&nbsp;Yuji Hayashi ,&nbsp;Kenzo Tsuzuki","doi":"10.1016/j.anl.2025.01.008","DOIUrl":"10.1016/j.anl.2025.01.008","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to clarify the characteristics of distant metastasis in patients with N1a and N1b papillary thyroid carcinoma (PTC) and the significance of lateral lymph node metastasis as a risk factor for distant metastasis.</div></div><div><h3>Methods</h3><div>Of the 537 patients with N1a and N1b PTC who underwent surgical treatment at Hyogo Medical University from January 2013 to December 2020 and Shikoku Cancer Center from January 2007 to December 2018, 283 (79 men and 204 women) with lymph node metastasis were analyzed in this study. The median age was 58 (range, 19–93) years, and the median observation period was 73 (range, 1–152) months after surgery.</div></div><div><h3>Results</h3><div>The incidence rate of distant metastasis was higher when metastases were detected at levels II or V. Multivariate analysis revealed that the factors that significantly increased the distant metastasis rate were age ≥ 55 years (<em>p</em> = 0.011), tumor size &gt; 4 cm (<em>p</em> = 0.034), and lymph node metastasis at levels II and V (<em>p</em> = 0.034).</div></div><div><h3>Conclusions</h3><div>For patients with N1b metastasis, specifically at levels II or V, total thyroidectomy with lateral neck dissection should be considered the primary choice for postoperative radioactive iodine therapy.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 2","pages":"Pages 174-178"},"PeriodicalIF":1.6,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of automated repositioning chair in refractory benign paroxysmal positional vertigo-a pilot study","authors":"Ozlem Bayram,&nbsp;Harun Kucuk,&nbsp;Burak Karabulut,&nbsp;Mustafa Canturk","doi":"10.1016/j.anl.2025.01.012","DOIUrl":"10.1016/j.anl.2025.01.012","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this study was to determine the overall success rate of automated canalith repositioning chair combined with videonystagmography (VNG) in the treatment of refractory benign paroxysmal positional vertigo (BPPV) patients who were initially treated unsuccessfully with conventionally performed canalith repositioning maneuvers (CRM) and whether can be a solution to enable easy CRM and make a difference in treatment success among BPPV subtypes.</div></div><div><h3>Methods</h3><div>Prospective study with 96 patients diagnosed with refractory benign paroxysmal positioning vertigo after initial CRM at primary health care centers between December 2022 and 2023 were treated by means of RMS™ combined with VNG as an automated repositioning chair at a tertiary university hospital in between December 2022 and 2023. Patients were deemed successfully treated if they displayed remission after three or less sessions within the span of a month.</div></div><div><h3>Results</h3><div>The mean number of required treatments was 1.42 with a success rate of 96.9%. Two horizontal canal and one multicanal BPPV needed more than three treatment sessions in one month span with 3.1 % treatment failure rate (defined as a need of &gt;3 sessions in one month)</div></div><div><h3>Conclusion</h3><div>RMS™ as an automated repositioning chair can be considered as an effective repositioning chair in the treatment of conventionally performed canalith repositioning maneuver resistant patients with success rates reaching 97 %.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 2","pages":"Pages 179-185"},"PeriodicalIF":1.6,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143386418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment outcomes of 73 cases of external auditory canal squamous cell carcinoma: A single-center six-year analysis in Japan","authors":"Tomoki Ooka ,&nbsp;Yosuke Ariizumi ,&nbsp;Takahiro Asakage ,&nbsp;Takeshi Tsutsumi","doi":"10.1016/j.anl.2025.02.001","DOIUrl":"10.1016/j.anl.2025.02.001","url":null,"abstract":"<div><h3>Objectives</h3><div>External auditory canal cancer (EAC) is a rare type among head and neck cancers, predominantly composed of squamous cell carcinoma (SCC) pathologically. Various comprehensive treatments including surgery, radiation therapy, and chemotherapy are conducted in many facilities for squamous cell carcinoma of the external auditory canal. However, due to its rarity, there is no established standard treatment. This study aimed to report the treatment outcomes at our single facility and prognostic factors post-surgery for EAC-SCC.</div></div><div><h3>Methods</h3><div>We conducted a retrospective analysis of 73 cases of EAC-SCC, which underwent initial treatment at our facility from July 2015 to November 2022. We utilized the modified Pittsburgh classification for TNM and staging.</div></div><div><h3>Results</h3><div>There were 37 male and 36 female cases, with a median age of 65 (ranging from 40 to 93). T1: 32 cases, T2: 5 cases, T3: 14 cases, T4: 10 cases. Stage Ⅰ: 28 cases, stage Ⅱ: 5 cases, stage Ⅲ: 12 cases, stage Ⅳ: 16 cases. The median follow-up period was 23.8 months (ranging from 2.8 to 93.6 months). There were 61 cases in the surgery group and 12 cases in the chemoradiotherapy (CRT) group. In survival analysis, the overall 3-year recurrence-free survival (RFS) rate was 81.9 %, and the 3-year disease-specific survival (DSS) rate was 89.1 %. For stage III/IV advanced cancers, the 3-year RFS rate was 78.3 % and DSS rate was 79.1 % in the surgery group, and in the CRT group, they were 66.7 % and 91.7 %, respectively. For T4 cases, the 3-year RFS rate was 58.3 % and DSS rate was 61.0 % in the surgery group, and in the primary CRT group, they were 75.0 % and 87.5 %, respectively. While there were no significant differences in treatment outcomes between the surgery and CRT groups overall, there was a trend suggesting better outcomes in the CRT group for T4 cases. In advanced cases (Stage III/IV, T3/4), younger females tended to be treated with CRT. Positive resection margins (HR: 11.97, 95 % CI: 1.80–79.70, <em>p</em> = 0.010) revealed to be a significant prognostic factor based on RFS.</div></div><div><h3>Conclusion</h3><div>We reported the treatment outcomes at a single facility and post-surgery prognostic factors. The treatment outcomes at our facility are comparable to other institutions, and in advanced cancers, the CRT group showed a tendency for better treatment outcomes. Post-surgery prognostic factor was positive resection margins.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 2","pages":"Pages 158-166"},"PeriodicalIF":1.6,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoglossal nerve stimulation with Inspire: An operative technique","authors":"Thomas Heineman ,&nbsp;Hirotaka Hara ,&nbsp;Seiichi Nakata ,&nbsp;Ayako Inoshita ,&nbsp;Nic Beckmann ,&nbsp;Hirokazu Uemura","doi":"10.1016/j.anl.2025.01.011","DOIUrl":"10.1016/j.anl.2025.01.011","url":null,"abstract":"<div><h3>Objective</h3><div>Obstructive sleep apnea is a chronic medical condition with a significant prevalence in Japan, estimated to be up to 22.3 % of the male working age population with moderate to severe OSA. Hypoglossal nerve stimulation (HNS) is now an established surgical treatment for obstructive sleep apnea. The surgical technique of the Inspire device has not been published in Japan.</div></div><div><h3>Methods</h3><div>This study involves combining existing best practice surgical techniques for hypoglossal stimulation implantation with the authors’ unique experiences.</div></div><div><h3>Results</h3><div>Surgical placement of the Inspire device is a safe and standardized operation. The surgery involves four principal steps: placement of the stimulation lead, placement of the sensing lead, tunneling of the stimulation lead with connection to the implantable pulse generator (IPG), and intraoperative functional testing. There is a standardized technique for these procedures which is discussed in detail. We also discuss known risks to the procedure.</div></div><div><h3>Conclusion</h3><div>Hypoglossal nerve stimulation with Inspire is a paradigm shift in the surgical treatment of obstructive sleep apnea. HNS is a surgery that can be readily learned and incorporated into a head and neck surgery practice with familiar technique and anatomy to other procedures within an otolaryngologists’ repertoire. A consistent surgical approach can maximize outcomes, reduce complications, and accelerate operative time.</div></div>","PeriodicalId":55627,"journal":{"name":"Auris Nasus Larynx","volume":"52 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}