Nicholas J Short, Elias Jabbour, Nitin Jain, Hagop Kantarjian
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引用次数: 0
Abstract
Inotuzumab ozogamicin (INO) is an anti-CD22 antibody-drug conjugate that was first evaluated in B-cell lymphomas but was subsequently shown to be highly effective in acute lymphoblastic leukemia (ALL). INO improved response rates and survival in a randomized study in adults with relapsed/refractory B-cell ALL, leading to its regulatory approval in the United States in 2017. While the formal approval for INO is as monotherapy in relapsed/refractory ALL, subsequent studies with INO administered in combination with chemotherapy and/or blinatumomab both in the frontline and salvage settings have yielded promising results. In this review, we discuss the clinical development of INO in ALL, highlighting lessons learned from the initial clinical trials of INO, as well as the many ongoing studies that are seeking to expand the role of INO in ALL.
伊诺珠单抗-奥佐加米星（INO）是一种抗 CD22 抗体-药物共轭物，首先在 B 细胞淋巴瘤中进行了评估，但随后被证明对急性淋巴细胞白血病（ALL）非常有效。在一项针对复发/难治B细胞ALL成人患者的随机研究中，INO提高了应答率和生存率，因此于2017年在美国获得监管部门批准。虽然INO是作为复发/难治性ALL的单一疗法获得正式批准的，但INO与化疗和/或blinatumomab联合用于一线和挽救性治疗的后续研究也取得了令人鼓舞的结果。在这篇综述中，我们将讨论 INO 在 ALL 中的临床开发，重点介绍 INO 初期临床试验的经验教训，以及许多正在进行的、旨在扩大 INO 在 ALL 中作用的研究。
期刊介绍：
The Journal of Hematology & Oncology, an open-access journal, publishes high-quality research covering all aspects of hematology and oncology, including reviews and research highlights on "hot topics" by leading experts.
Given the close relationship and rapid evolution of hematology and oncology, the journal aims to meet the demand for a dedicated platform for publishing discoveries from both fields. It serves as an international platform for sharing laboratory and clinical findings among laboratory scientists, physician scientists, hematologists, and oncologists in an open-access format. With a rapid turnaround time from submission to publication, the journal facilitates real-time sharing of knowledge and new successes.
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