[Prevalence and genotypic characteristics of anal papillomavirus infection in a cohort of HIV-positive men who have sex with men].

Q4 Medicine Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru Pub Date : 2024-01-01

Jaime A Collins, Miriam L Soria, José C Ballena, Raúl A Castillo

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Abstract

Objective: To determine the prevalence and genotypic characteristics of anal papillomaviruses in HIV-positive men who have sex with men (MSM).

Materials and methods: This is a prospective cross-sectional observational study of HIV-positive MSM at Almenara General Hospital between September 2017 and December 2018. HPV detection and typing was performed using a polymerase chain reaction technique that evaluated 21 genotypes stratified according to oncogenic risk into six low-risk and fifteen high-risk.

Results: we evaluated 214 HIV-positive MSM. The overall prevalence of anal infection by papillomavirus infection was 70% (150/214). 86% (129/150) were caused by high-risk genotypes, 79% (102/129) of them were affected by a two or more-papillomavirus genotype. The most frequent high-risk genotypes were HPV-16, 31% (46/150); HPV-52, 22% (33/150); HPV-33, 21% (31/150); HPV-58, 21% (31/150) and HPV-31, 20% (30/150). In addition, HPV-18 reached 7% (10/150). The most frequent low-risk genotypes were HPV-6, 30% (45/150) and HPV-11, 29% (44/150).

Conclusions: Prevalence of anal papillomavirus infection in HIV-positive MSM is very high in the hospital investigated. Most of these infections occurs with high-risk oncogenic genotypes. Papillomavirus 16 was the most frequent high-risk genotype.

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[男男性行为者艾滋病毒阳性人群中肛乳头瘤病毒感染的流行率和基因型特征]。

摘要确定 HIV 阳性男男性行为者（MSM）中肛乳头瘤病毒的流行率和基因型特征：这是一项前瞻性横断面观察研究，研究对象为 2017 年 9 月至 2018 年 12 月期间在阿尔梅纳拉综合医院就诊的 HIV 阳性 MSM。采用聚合酶链反应技术进行了HPV检测和分型，根据致癌风险将21种基因型分为6种低危基因型和15种高危基因型。肛门乳头瘤病毒感染的总发病率为 70%（150/214）。86%（129/150）是由高危基因型引起的，其中 79%（102/129）受到两种或两种以上乳头瘤病毒基因型的影响。最常见的高危基因型是 HPV-16，占 31%（46/150）；HPV-52，占 22%（33/150）；HPV-33，占 21%（31/150）；HPV-58，占 21%（31/150）；HPV-31，占 20%（30/150）。此外，HPV-18 达 7%（10/150）。最常见的低风险基因型是 HPV-6，30%（45/150）和 HPV-11，29%（44/150）：结论：在所调查的医院中，HIV 阳性 MSM 感染肛门乳头瘤病毒的比例非常高。这些感染大多发生在高危致癌基因型上。乳头瘤病毒 16 是最常见的高危基因型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru Medicine-Medicine (all)

CiteScore

0.40

自引率

0.00%

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期刊介绍： La REVISTA DE GASTROENTEROLOGíA DEL PERÚ, es la publicación oficial de la Sociedad de Gastroenterología del Perú que publica artículos originales, artículos de revisión, reporte de casos, cartas e información general de la especialidad; dirigido a los profesionales de la salud con especial interés en la gastroenterología. La Revista de Gastroenterología del Perú es una publicación de periodicidad trimestral y tiene como objetivo la publicación de artículos científicos inéditos en el campo de la gastroenterología, proporcionando información actualizada y relevante de la especialidad y áreas afines. La Revista de Gastroenterología del Perú publica artículos en dos idiomas, español e inglés, a texto completo en la versión impresa yelectrónica. Los artículos científicos son sometidos a revisores o árbitros nacionales e internacionales, especialistas que opinan bajo la modalidad de doble ciego y de manera anónima sobre la calidad y validez de los mismos. El número de revisores depende del tipo de artículo, dos revisores como mínimo para artículos originales y uno como mínimo para otros tipos de artículos.