Hypo-Albuminemia and Perioperative Renal Transplant-Related Infections: A Systematic Review and Meta-Analysis.

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY Urology Journal Pub Date : 2024-10-12 DOI:10.22037/uj.v21i.7943

Abdolreza Mohammadi, Seyed Hassan Inanloo, AhmadReza Rezaeian, Iman Menbari Oskouie, Alireza Khajavi, Akram Mirzaei, Mahin Ahmadi Pishkuhi, Leonardo Oliveira Reis, Seyed Mohammad Kazem Aghamir

{"title":"Hypo-Albuminemia and Perioperative Renal Transplant-Related Infections: A Systematic Review and Meta-Analysis.","authors":"Abdolreza Mohammadi, Seyed Hassan Inanloo, AhmadReza Rezaeian, Iman Menbari Oskouie, Alireza Khajavi, Akram Mirzaei, Mahin Ahmadi Pishkuhi, Leonardo Oliveira Reis, Seyed Mohammad Kazem Aghamir","doi":"10.22037/uj.v21i.7943","DOIUrl":null,"url":null,"abstract":"Objective: to review the literature regarding the relationship between pre- and post-transplant hypo-Albuminemia with various renal transplant-related infections.Materials and methods: In a systematic review, we included the following keywords in the search: (Albumin*) AND (infection*) AND (\"renal transplant\" OR \"renal transplantation\" OR \"renal transplants\") OR (\"kidney transplant\" OR \"kidney transplantation\" OR \"kidney transplants\") OR \"kidney grafting\") with investigating databases including ProQuest, PubMed, Scopus, and Web of Science to May 2023. All adult patients who had renal transplantation were included. Albumin levels of infected (bacterial, fungal, or viral) patients and the type of infection should be reported in the included studies. The search strategy used in this review was reported by Preferred Reporting Items for Systematic Reviews and Meta-Analyses literature search extension (PRISMA-S). To conduct Meta-analyses, Stata version 17 was used. Also, DerSimonian-Laird random-effects models were used for this study. In our study, heterogeneity was quantified with I2 and τ2 statistics. Inconsistency across studies is quantified by I2 statistics, and the impact of heterogeneity on the meta-analysis is assessed by this quantification.Results: Overall, 18 studies were found to be reporting measures of association including risk ratio, odds ratio, and, hazard ratio. Among them, 10 and 8 studies reported bacterial and viral types of infection. The combined risk ratios were not statistically significant, in either type of infection. The mean (SD) of ages for bacterial and viral infections were found to be 45.3 (6.4) and 50.5 (7.6) years old, respectively.Conclusion: Hypoalbuminemia is not related to post-transplantation infections, and it seems that with adherence to proper pretransplant screening of recipients, vaccination, and post-transplant surveillance and prophylaxis, the impact of infections may be reduced.","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":"274-282"},"PeriodicalIF":1.5000,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Urology Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.22037/uj.v21i.7943","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: to review the literature regarding the relationship between pre- and post-transplant hypo-Albuminemia with various renal transplant-related infections.

Materials and methods: In a systematic review, we included the following keywords in the search: (Albumin*) AND (infection*) AND ("renal transplant" OR "renal transplantation" OR "renal transplants") OR ("kidney transplant" OR "kidney transplantation" OR "kidney transplants") OR "kidney grafting") with investigating databases including ProQuest, PubMed, Scopus, and Web of Science to May 2023. All adult patients who had renal transplantation were included. Albumin levels of infected (bacterial, fungal, or viral) patients and the type of infection should be reported in the included studies. The search strategy used in this review was reported by Preferred Reporting Items for Systematic Reviews and Meta-Analyses literature search extension (PRISMA-S). To conduct Meta-analyses, Stata version 17 was used. Also, DerSimonian-Laird random-effects models were used for this study. In our study, heterogeneity was quantified with I2 and τ2 statistics. Inconsistency across studies is quantified by I2 statistics, and the impact of heterogeneity on the meta-analysis is assessed by this quantification.

Results: Overall, 18 studies were found to be reporting measures of association including risk ratio, odds ratio, and, hazard ratio. Among them, 10 and 8 studies reported bacterial and viral types of infection. The combined risk ratios were not statistically significant, in either type of infection. The mean (SD) of ages for bacterial and viral infections were found to be 45.3 (6.4) and 50.5 (7.6) years old, respectively.

Conclusion: Hypoalbuminemia is not related to post-transplantation infections, and it seems that with adherence to proper pretransplant screening of recipients, vaccination, and post-transplant surveillance and prophylaxis, the impact of infections may be reduced.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

低白蛋白血症与肾移植围手术期相关感染：系统回顾与元分析》。

目的：回顾有关移植前后低白蛋白血症与各种肾移植相关感染之间关系的文献：在一项系统性综述中，我们在检索中包含了以下关键词：（白蛋白*）和（感染*）和（"肾移植 "或 "肾移植 "或 "肾移植"）或（"肾移植 "或 "肾移植 "或 "肾移植"）或 "肾移植"），调查数据库包括 ProQuest、PubMed、Scopus 和 Web of Science，检索期至 2023 年 5 月。所有接受肾移植的成年患者均被纳入研究范围。纳入的研究应报告感染（细菌、真菌或病毒）患者的白蛋白水平以及感染类型。本综述采用的检索策略由系统综述和Meta分析文献检索扩展报告（Preferred Reporting Items for Systematic Reviews and Meta-Analyses，PRISMA-S）提供。进行 Meta 分析时使用了 Stata 17 版本。本研究还使用了 DerSimonian-Laird 随机效应模型。在我们的研究中，异质性通过 I2 和 τ2 统计量进行量化。各研究之间的不一致性通过 I2 统计量进行量化，异质性对元分析的影响通过该量化进行评估：总体而言，有 18 项研究报告了相关性指标，包括风险比、几率比和危险比。其中，分别有 10 项和 8 项研究报告了细菌和病毒感染类型。两种感染类型的综合风险比均无统计学意义。细菌和病毒感染的平均（标清）年龄分别为 45.3 (6.4) 岁和 50.5 (7.6)岁：低白蛋白血症与移植后感染无关，只要坚持对受者进行适当的移植前筛查、疫苗接种以及移植后监测和预防，似乎可以减少感染的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Urology Journal UROLOGY & NEPHROLOGY-

CiteScore

2.60

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： As the official journal of the Urology and Nephrology Research Center (UNRC) and the Iranian Urological Association (IUA), Urology Journal is a comprehensive digest of useful information on modern urology. Emphasis is on practical information that reflects the latest diagnostic and treatment techniques. Our objectives are to provide an exceptional source of current and clinically relevant research in the discipline of urology, to reflect the scientific work and progress of our colleagues, and to present the articles in a logical, timely, and concise format that meets the diverse needs of today’s urologist. Urology Journal publishes manuscripts on urology and kidney transplantation, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. Accordingly, original articles, case reports, and letters to editor are encouraged.