Time-to-Event Endpoints in Imaging Biomarker Studies

IF 3.3 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Journal of Magnetic Resonance Imaging Pub Date : 2024-05-13 DOI:10.1002/jmri.29446

Ruizhe Chen PhD, Hao Wang PhD

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引用次数: 0

Abstract

Time-to-event endpoints are widely used as measures of patients' well-being and indicators of prognosis. In imaging-based biomarker studies, there are increasingly more studies that focus on examining imaging biomarkers' prognostic or predictive utilities on those endpoints, whether in a trial or an observational study setting. In this educational review article, we briefly introduce some basic concepts of time-to-event endpoints and point out potential pitfalls in the context of imaging biomarker research in hope of improving radiologists' understanding of related subjects. Besides, we have included some review and discussions on the benefits of using time-to-event endpoints and considerations on selecting overall survival or progression-free survival for primary analysis.

Level of Evidence

Technical Efficacy

Stage 3

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成像生物标记物研究中的事件时间终点。

时间到事件终点被广泛用作衡量患者健康状况和预后的指标。在基于成像的生物标记物研究中，越来越多的研究侧重于检查成像生物标记物对这些终点的预后或预测作用，无论是在试验中还是在观察性研究环境中。在这篇教育性综述文章中，我们简要介绍了时间到事件终点的一些基本概念，并指出了影像生物标志物研究中可能存在的误区，希望能提高放射科医生对相关课题的理解。此外，我们还对使用时间到事件终点的益处以及选择总生存期或无进展生存期作为主要分析的注意事项进行了回顾和讨论。证据级别：5 技术功效：第 3 阶段。

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来源期刊

Journal of Magnetic Resonance Imaging 医学-核医学

CiteScore

9.70

自引率

6.80%

发文量

494

审稿时长

2 months

期刊介绍： The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.