Hedyotis diffusa Willd inhibits inflammation and oxidative stress to protect against chronic prostatitis via the NRF2/ARE signaling pathway

IF 4.4 3区医学 Q2 ENVIRONMENTAL SCIENCES Environmental Toxicology Pub Date : 2024-05-13 DOI:10.1002/tox.24298

Junfu Mo, Kang Xia, Chaokui Wu

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Abstract

Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a common and serious disease with unclear pathogenesis and recurrent symptoms. Hedyotis diffusa Willd (HDW) has been recognized for its potential in managing various chronic inflammatory diseases. This research aimed to interrogate the mechanism of HDW in treating CP/CPPS. Complete Freund Adjuvant (CFA) and LPS were utilized to establish the rat and cell models of CP/CPPS. Results showed that HDW decreased levels of inflammation-related factors in CP rat prostate tissue and LPS-elicited RWPE-1 cell injury model. Moreover, HDW administration impaired oxidative stress in the prostate and RWPE-1 cells. In addition, HDW treatment activated the NRF2/ARE signaling in rat prostate tissue and cell models. Interestingly, NRF2/ARE pathway inhibitor ML385 reversed the inhibition effects of cell apoptosis, inflammation, and oxidative stress triggered by HDW. In summary, HDW alleviated inflammation and oxidative stress by activating NRF2/ARE signaling in CP/CPPS rat model and human prostate epithelial cell injury model.

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Hedyotis diffusa Willd 可通过 NRF2/ARE 信号通路抑制炎症和氧化应激，从而预防慢性前列腺炎。

慢性前列腺炎/慢性盆腔疼痛综合征（CP/CPPS）是一种常见的严重疾病，发病机制不明，症状反复发作。Hedyotis diffusa Willd（HDW）被认为具有治疗各种慢性炎症的潜力。本研究旨在探讨HDW治疗CP/CPPS的机制。研究人员利用全氟佐剂（CFA）和LPS建立了CP/CPPS大鼠和细胞模型。结果表明，HDW能降低CP大鼠前列腺组织和LPS诱导的RWPE-1细胞损伤模型中炎症相关因子的水平。此外，服用 HDW 还能减轻前列腺和 RWPE-1 细胞中的氧化应激。此外，HDW 还能激活大鼠前列腺组织和细胞模型中的 NRF2/ARE 信号传导。有趣的是，NRF2/ARE 通路抑制剂 ML385 逆转了 HDW 对细胞凋亡、炎症和氧化应激的抑制作用。总之，在 CP/CPPS 大鼠模型和人类前列腺上皮细胞损伤模型中，HDW 通过激活 NRF2/ARE 信号传导缓解了炎症和氧化应激。

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来源期刊

Environmental Toxicology 环境科学-毒理学

CiteScore

7.10

自引率

8.90%

发文量

261

审稿时长

4.5 months

期刊介绍： The journal publishes in the areas of toxicity and toxicology of environmental pollutants in air, dust, sediment, soil and water, and natural toxins in the environment.Of particular interest are: Toxic or biologically disruptive impacts of anthropogenic chemicals such as pharmaceuticals, industrial organics, agricultural chemicals, and by-products such as chlorinated compounds from water disinfection and waste incineration; Natural toxins and their impacts; Biotransformation and metabolism of toxigenic compounds, food chains for toxin accumulation or biodegradation; Assays of toxicity, endocrine disruption, mutagenicity, carcinogenicity, ecosystem impact and health hazard; Environmental and public health risk assessment, environmental guidelines, environmental policy for toxicants.