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Dendranthema oreastrum (Hance) Y.Ling Attenuates Oxidative Stress and Airway Inflammation in a Murine Model of Lipopolysaccharide‐Induced Acute Lung Injury Dendranthema oreastrum (Hance) Y.Ling 在脂多糖诱导的急性肺损伤小鼠模型中减轻氧化应激和气道炎症
IF 4.5 3区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-04-23 DOI: 10.1002/tox.24520
Ji‐Hye Ha, Ba‐Wool Lee, Da‐Hye Yi, Seong‐Hun Jeong, Ju‐Hong Kim, Hyun‐Jae Jang, Ju Hwan Jeong, Ji‐Young Park, Hyung Jae Jeong, Hyung‐Jun Kwon, Young‐Bae Ryu, In‐Chul Lee
We examined the antioxidant and anti‐inflammatory effects of the methanolic extract of Dendranthema oreastrum (Hance) Y.Ling, commonly known as “Gu‐Jeol‐Cho” in Korea and widely found across East Asia, using an LPS‐induced acute lung injury (ALI) mouse model and TNF‐α‐stimulated NCI‐H292 cells. LPS was intratracheally administered at 20 μg/50 μL/mouse for 3 days. From test day 1 to 5, experimental mice were administered DO (100 and 200 mg/kg/day) or dexamethasone (3 mg/kg/day). DO treatment decreased pro‐inflammatory cytokines in bronchoalveolar lavage fluid and TNF‐α‐stimulated NCI‐H292 cells. Additionally, DO treatment decreased alveolar wall thickening and inflammatory cell infiltration in lung tissues. DO down‐regulated TXNIP expression, inhibiting NF‐κB activation. Furthermore, DO administration reduced NLRP3 inflammasome activity by preventing the activation of caspase‐1 and IL‐1β. Additionally, DO promoted the nuclear translocation of Nrf2‐related factors, leading to an upregulation of antioxidant enzymes. The study demonstrated that DO administration markedly decreased reactive oxygen species and lipid peroxidation. These observations indicate that DO is a therapeutic agent for ALI.
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引用次数: 0
RETRACTION: FOXA2 Suppresses Gallbladder Carcinoma Cell Migration, Invasion, and Epithelial‐Mesenchymal Transition by Targeting SERPINB5
IF 4.5 3区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-04-22 DOI: 10.1002/tox.24522
RETRACTION: L. Hong, M. Chen, M. Huang, W. Chen, X. Abudukeremu, F. She, and Y. Chen, “,” Environmental Toxicology 39, no. (2024): 708722, https://doi.org/10.1002/tox.23953.The above article, published online on 4 September 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor‐in‐Chief, April Rodd; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted. The authors have been informed of this decision.
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引用次数: 0
RETRACTION: Eosinophils and Risk of Ulcerative Colitis in European Population: Evidence from Mendelian Randomization Study
IF 4.5 3区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-04-22 DOI: 10.1002/tox.24526
RETRACTION: Y. Shao, C. Liu, X. Wang, and W. Zhu, “,” Environmental Toxicology 39, no. (2024): 46694676, https://doi.org/10.1002/tox.24314.The above article, published online on 29 April 2024 in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor‐in‐Chief, April Rodd; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted. The authors have been informed of this decision.
{"title":"RETRACTION: Eosinophils and Risk of Ulcerative Colitis in European Population: Evidence from Mendelian Randomization Study","authors":"","doi":"10.1002/tox.24526","DOIUrl":"https://doi.org/10.1002/tox.24526","url":null,"abstract":"<jats:mixed-citation publication-type=\"journal\">RETRACTION: <jats:string-name><jats:given-names>Y.</jats:given-names> <jats:surname>Shao</jats:surname></jats:string-name>, <jats:string-name><jats:given-names>C.</jats:given-names> <jats:surname>Liu</jats:surname></jats:string-name>, <jats:string-name><jats:given-names>X.</jats:given-names> <jats:surname>Wang</jats:surname></jats:string-name>, and <jats:string-name><jats:given-names>W.</jats:given-names> <jats:surname>Zhu</jats:surname></jats:string-name>, “,” <jats:source>Environmental Toxicology</jats:source> <jats:volume>39</jats:volume>, no. (<jats:year>2024</jats:year>): <jats:fpage>4669</jats:fpage>–<jats:lpage>4676</jats:lpage>, <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"https://doi.org/10.1002/tox.24314\">https://doi.org/10.1002/tox.24314</jats:ext-link>.</jats:mixed-citation>The above article, published online on 29 April 2024 in Wiley Online Library (<jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"http://onlinelibrary.wiley.com/\">http://onlinelibrary.wiley.com/</jats:ext-link>), has been retracted by agreement between the journal Editor‐in‐Chief, April Rodd; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted. The authors have been informed of this decision.","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"24 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RETRACTION: Elucidating the Molecular Mechanisms of Sepsis: Identifying Key Aging‐Related Biomarkers and Potential Therapeutic Targets in the Treatment of Sepsis
IF 4.5 3区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-04-22 DOI: 10.1002/tox.24524
RETRACTION: J. Zhou, J. Liu, C. Zhang, Y. Zhou, Z. Zheng, and H. Li, “,” Environmental Toxicology 39, no. (2024): 33413355, https://doi.org/10.1002/tox.24198.The above article, published online on 5 March 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor‐in‐Chief, April Rodd; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted. The authors have been informed of this decision.
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引用次数: 0
RETRACTION: Value of Hepatic Artery Digital Subtraction Angiography in the Detection of Small Hepatocellular Carcinoma Lesions
IF 4.5 3区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-04-22 DOI: 10.1002/tox.24527
RETRACTION: T. Bai, S. Lu, J. Chen, J. Ye, X. Wang, Z. Tang, H. Fu, L. Li, and F. Wu, “,” Environmental Toxicology 39, no. (2024): 47544762, https://doi.org/10.1002/tox.24316.The above article, published online on 20 August 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor‐in‐Chief, April Rodd; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted. The authors disagree with this decision.
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引用次数: 0
RETRACTION: Exosomal miRNA‐166‐5p Derived from G‐MDSCs Promotes Proliferation by Targeting ITM3E in Colorectal Cancer
IF 4.5 3区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-04-22 DOI: 10.1002/tox.24523
RETRACTION: T. Ma, J. Jiang, M. Shi, and H. Xu, “,” Environmental Toxicology 39, no. (2024): 803814, https://doi.org/10.1002/tox.23980.The above article, published online on 4 October 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), and its correction, has been retracted by agreement between the journal Editor‐in‐Chief, April Rodd; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Additionally, no ethical approval was provided for the human studies portion. Therefore, the article must be retracted. The authors agree with this decision.
撤回:T. Ma, J. Jiang, M. Shi, and H. Xu, "," Environmental Toxicology 39, no:803-814, https://doi.org/10.1002/tox.23980.The 上述文章于 2023 年 10 月 4 日在线发表于 Wiley Online Library (http://onlinelibrary.wiley.com/),根据期刊主编 April Rodd 和 Wiley Periodicals LLC 之间的协议,该文章及其更正已被撤回。经过出版商的调查,双方认为这篇文章被接受的唯一原因是同行评审程序有问题。此外,人体研究部分未获得伦理批准。因此,该文章必须撤回。作者同意这一决定。
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引用次数: 0
RETRACTION: Scoparone Inhibits the Development of Hepatocellular Carcinoma by Modulating the p38 MAPK/Akt/NF‐κB Signaling in Nonalcoholic Fatty Liver Disease Mice
IF 4.5 3区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-04-22 DOI: 10.1002/tox.24521
RETRACTION: M. Ye, C. Liu, J. Liu, F. Lu, J. Xue, F. Li, and Y. Tang, “,” Environmental Toxicology 39, no. (2024): 551561, https://doi.org/10.1002/tox.23851.The above article, published online on 12 July 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor‐in‐Chief, April Rodd; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted. The authors have been informed of this decision.
撤回:M. Ye, C. Liu, J. Liu, F. Lu, J. Xue, F. Li, and Y. Tang, "," Environmental Toxicology 39, no:551-561, https://doi.org/10.1002/tox.23851.The 上述文章于 2023 年 7 月 12 日在线发表于 Wiley Online Library (http://onlinelibrary.wiley.com/),经期刊主编 April Rodd 和 Wiley Periodicals LLC 协议,该文章已被撤回。经过出版商的调查,双方得出结论,这篇文章被接受的唯一依据是同行评议程序有问题。因此,该文章必须撤回。此决定已通知作者。
{"title":"RETRACTION: Scoparone Inhibits the Development of Hepatocellular Carcinoma by Modulating the p38 MAPK/Akt/NF‐κB Signaling in Nonalcoholic Fatty Liver Disease Mice","authors":"","doi":"10.1002/tox.24521","DOIUrl":"https://doi.org/10.1002/tox.24521","url":null,"abstract":"<jats:mixed-citation publication-type=\"journal\">RETRACTION: <jats:string-name><jats:given-names>M.</jats:given-names> <jats:surname>Ye</jats:surname></jats:string-name>, <jats:string-name><jats:given-names>C.</jats:given-names> <jats:surname>Liu</jats:surname></jats:string-name>, <jats:string-name><jats:given-names>J.</jats:given-names> <jats:surname>Liu</jats:surname></jats:string-name>, <jats:string-name><jats:given-names>F.</jats:given-names> <jats:surname>Lu</jats:surname></jats:string-name>, <jats:string-name><jats:given-names>J.</jats:given-names> <jats:surname>Xue</jats:surname></jats:string-name>, <jats:string-name><jats:given-names>F.</jats:given-names> <jats:surname>Li</jats:surname></jats:string-name>, and <jats:string-name><jats:given-names>Y.</jats:given-names> <jats:surname>Tang</jats:surname></jats:string-name>, “,” <jats:source>Environmental Toxicology</jats:source> <jats:volume>39</jats:volume>, no. (<jats:year>2024</jats:year>): <jats:fpage>551</jats:fpage>–<jats:lpage>561</jats:lpage>, <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"https://doi.org/10.1002/tox.23851\">https://doi.org/10.1002/tox.23851</jats:ext-link>.</jats:mixed-citation>The above article, published online on 12 July 2023, in Wiley Online Library (<jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"http://onlinelibrary.wiley.com/\">http://onlinelibrary.wiley.com/</jats:ext-link>), has been retracted by agreement between the journal Editor‐in‐Chief, April Rodd; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted. The authors have been informed of this decision.","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"3 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RETRACTION: Integrated Analysis of Gut Microbiota and Metabolomic Profiling in Colorectal Cancer Metastasis.
IF 4.5 3区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-04-21 DOI: 10.1002/tox.24525
Y. Xia, L. Duan, X.L. Zhang, Y.J. Niu, and X. Ling, "Integrated Analysis of Gut Microbiota and Metabolomic Profiling in Colorectal Cancer Metastasis," Environmental Toxicology 39, no. 10 (2024): 4467-4478, https://doi.org/10.1002/tox.24228. The above article, published online on 14 March 2024 in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, Christyn Bailey; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted.
{"title":"RETRACTION: Integrated Analysis of Gut Microbiota and Metabolomic Profiling in Colorectal Cancer Metastasis.","authors":"","doi":"10.1002/tox.24525","DOIUrl":"https://doi.org/10.1002/tox.24525","url":null,"abstract":"Y. Xia, L. Duan, X.L. Zhang, Y.J. Niu, and X. Ling, \"Integrated Analysis of Gut Microbiota and Metabolomic Profiling in Colorectal Cancer Metastasis,\" Environmental Toxicology 39, no. 10 (2024): 4467-4478, https://doi.org/10.1002/tox.24228. The above article, published online on 14 March 2024 in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, Christyn Bailey; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted.","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"12 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to “Hydroxysafflor Yellow A Attenuates Allergic Response of Ovalbumin Induced Allergic Rhinitis via Nrf2/HO‐1 and Inflammatory Signaling Pathways”
IF 4.5 3区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-04-16 DOI: 10.1002/tox.24518
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引用次数: 0
Analysis of PM2.5 Morphology, Composition and Health Risk in a Multi-Chair Dental Clinic.
IF 4.4 3区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-04-09 DOI: 10.1002/tox.24519
Fengqin Tang, Shengcai Qi, Xiaoshan Tang, Xueyun Wen, Yiming Zhang, Guotao Peng, Jieying Huang, Guangwei Shang, Xu Zhang, Fubo Chen, Yuanzhi Xu, Jing Cai

Particulate matter with aerodynamic diameter ≤ 2.5 μm (PM2.5) at high concentrations in dental clinics poses significant health risks to healthcare professionals. However, the morphology and chemical composition of PM2.5 in specific environments are not yet fully elucidated. In this study, we investigated the concentration, morphology, chemical composition, and health assessment of PM2.5 collected in a multi-chair dental clinic in Shanghai, China. Scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS) were performed to observe the morphology and elemental composition of indoor and outdoor PM2.5. Chemicals were measured for their concentrations using X-ray fluorescence spectrometry (XRF). In the dental clinic, the indoor PM2.5 concentration ranged from 2.01 to 114.59 μg/m3, with a mean of 23.31 μg/m3, while the outdoor PM2.5 concentration ranged from 2.88 to 157.4 μg/m3, with a mean of 30.98 μg/m3. Indoor particles showed more rough, irregular mineralization, which was confirmed as the dominant elements of Ca, P, Si, and zirconia (Zr) by EDS. The average concentrations of Ca, P, Cu, Sr, and Sb indoors were lower than those outdoors (p < 0.05). We also found that Cd, As, and Ni exceeded the annual limits of the Ambient Air Quality Standards of WHO. For the health assessment, the carcinogenic risks of Cd, As, and Cr were higher than the minimum acceptable level (1 × 10-6), with values of 3.68 × 10-5, 1.10 × 10,-5 and 5.52 × 10-6, respectively, and the non-carcinogenic risk of Cd was the highest, as illustrated by the Hazard Quotient of 2.04. These findings indicate that dental healthcare professionals may be exposed to PM2.5 containing high concentrations of toxic metals and carcinogenic elements over the long term. This study highlights the importance of protective measures (e.g., the adoption of efficient air purification systems) to minimize the risk of particle inhalation for both patients and professionals.

牙科诊所中空气动力学直径≤ 2.5 μm(PM2.5)的颗粒物浓度较高,对医护人员的健康构成重大威胁。然而,特定环境中 PM2.5 的形态和化学成分尚未完全阐明。在这项研究中,我们调查了在中国上海一家多椅牙科诊所中收集到的 PM2.5 的浓度、形态、化学成分和健康评估。通过扫描电子显微镜(SEM)和能量色散 X 射线光谱(EDS)来观察室内和室外 PM2.5 的形态和元素组成。使用 X 射线荧光光谱法(XRF)测量了化学物质的浓度。在牙科诊所,室内 PM2.5 浓度范围为 2.01 至 114.59 μg/m3,平均值为 23.31 μg/m3,而室外 PM2.5 浓度范围为 2.88 至 157.4 μg/m3,平均值为 30.98 μg/m3。室内颗粒呈现出更粗糙、不规则的矿化现象,经 EDS 确认,主要元素为 Ca、P、Si 和氧化锆(Zr)。室内钙、磷、铜、锶和锑的平均浓度低于室外(p -6),分别为 3.68 × 10-5、1.10 × 10,-5 和 5.52 × 10-6,镉的非致癌风险最高,危害商数为 2.04。这些研究结果表明,牙科医护人员可能长期暴露于含有高浓度有毒金属和致癌元素的 PM2.5。这项研究强调了采取防护措施(如采用高效空气净化系统)的重要性,以尽量减少患者和专业人员吸入微粒的风险。
{"title":"Analysis of PM<sub>2.5</sub> Morphology, Composition and Health Risk in a Multi-Chair Dental Clinic.","authors":"Fengqin Tang, Shengcai Qi, Xiaoshan Tang, Xueyun Wen, Yiming Zhang, Guotao Peng, Jieying Huang, Guangwei Shang, Xu Zhang, Fubo Chen, Yuanzhi Xu, Jing Cai","doi":"10.1002/tox.24519","DOIUrl":"https://doi.org/10.1002/tox.24519","url":null,"abstract":"<p><p>Particulate matter with aerodynamic diameter ≤ 2.5 μm (PM<sub>2.5</sub>) at high concentrations in dental clinics poses significant health risks to healthcare professionals. However, the morphology and chemical composition of PM<sub>2.5</sub> in specific environments are not yet fully elucidated. In this study, we investigated the concentration, morphology, chemical composition, and health assessment of PM<sub>2.5</sub> collected in a multi-chair dental clinic in Shanghai, China. Scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS) were performed to observe the morphology and elemental composition of indoor and outdoor PM<sub>2.5</sub>. Chemicals were measured for their concentrations using X-ray fluorescence spectrometry (XRF). In the dental clinic, the indoor PM<sub>2.5</sub> concentration ranged from 2.01 to 114.59 μg/m<sup>3</sup>, with a mean of 23.31 μg/m<sup>3</sup>, while the outdoor PM<sub>2.5</sub> concentration ranged from 2.88 to 157.4 μg/m<sup>3</sup>, with a mean of 30.98 μg/m<sup>3</sup>. Indoor particles showed more rough, irregular mineralization, which was confirmed as the dominant elements of Ca, P, Si, and zirconia (Zr) by EDS. The average concentrations of Ca, P, Cu, Sr, and Sb indoors were lower than those outdoors (p < 0.05). We also found that Cd, As, and Ni exceeded the annual limits of the Ambient Air Quality Standards of WHO. For the health assessment, the carcinogenic risks of Cd, As, and Cr were higher than the minimum acceptable level (1 × 10<sup>-6</sup>), with values of 3.68 × 10<sup>-5</sup>, 1.10 × 10,<sup>-5</sup> and 5.52 × 10<sup>-6</sup>, respectively, and the non-carcinogenic risk of Cd was the highest, as illustrated by the Hazard Quotient of 2.04. These findings indicate that dental healthcare professionals may be exposed to PM<sub>2.5</sub> containing high concentrations of toxic metals and carcinogenic elements over the long term. This study highlights the importance of protective measures (e.g., the adoption of efficient air purification systems) to minimize the risk of particle inhalation for both patients and professionals.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Environmental Toxicology
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