{"title":"Reductionism and proxy failure: From neuroscience to target-based drug discovery.","authors":"Arash Sadri, Sepideh Paknezhad","doi":"10.1017/S0140525X23002893","DOIUrl":null,"url":null,"abstract":"<p><p>Reductionist methodologies reduce phenomena to some of their lower-level components. Researchers gradually shift their focus away from observing the actual object of study toward investigating and optimizing such lower-level proxies. Following reductionism, these proxies progressively diverge further from the original object of study. We vividly illustrate this in the evolution of target-based drug discovery from rational and phenotypic drug discovery.</p>","PeriodicalId":8698,"journal":{"name":"Behavioral and Brain Sciences","volume":"47 ","pages":"e83"},"PeriodicalIF":13.7000,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Behavioral and Brain Sciences","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1017/S0140525X23002893","RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Reductionist methodologies reduce phenomena to some of their lower-level components. Researchers gradually shift their focus away from observing the actual object of study toward investigating and optimizing such lower-level proxies. Following reductionism, these proxies progressively diverge further from the original object of study. We vividly illustrate this in the evolution of target-based drug discovery from rational and phenotypic drug discovery.
期刊介绍：
Behavioral and Brain Sciences (BBS) is a highly respected journal that employs an innovative approach called Open Peer Commentary. This format allows for the publication of noteworthy and contentious research from various fields including psychology, neuroscience, behavioral biology, and cognitive science. Each article is accompanied by 20-40 commentaries from experts across these disciplines, as well as a response from the author themselves. This unique setup creates a captivating forum for the exchange of ideas, critical analysis, and the integration of research within the behavioral and brain sciences, spanning topics from molecular neurobiology and artificial intelligence to the philosophy of the mind.
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