Bilastine for the treatment of allergic rhinoconjunctivitis and urticaria: results from an international Delphi study.

Q2 Pharmacology, Toxicology and Pharmaceutics Drugs in Context Pub Date : 2024-05-01 eCollection Date: 2024-01-01 DOI:10.7573/dic.2024-2-3
Giorgio Walter Canonica, Piotr Kuna, Marcus Maurer, Ralph Mösges, Zoltan Novak, Nikolaus Papadopoulos, Pablo Rodriguez Del Rio
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Abstract

Background: Second-generation oral H1-antihistamines, including bilastine, represent the emerging treatments of allergic rhinitis (including rhinoconjunctivitis) and chronic urticaria in both adults and children. This study analyses available evidence supporting the use of bilastine amongst second-generation antihistamines for the symptomatic treatment of allergic rhinitis and urticaria in adults and children.

Methods: Consensus amongst experts from 17 countries on the ideal treatment of rhinitis and urticaria, and the specific role of bilastine was measured by means of a modified Delphi process. A total of 12 statements were voted on by the experts using a five-point Likert scale (1 = strongly disagree; 2 = disagree; 3 = undecided; 4 = agree; 5 = strongly agree). The definition of consensus was set at a minimum of 80% concordance for 4+5 scores (agree or strongly agree).

Results: All proposed statements reached consensus, with a concordance of ≥98% for five statements and ≥96% for seven.

Conclusions: The wide consensus obtained for the proposed statements suggests a prominent role for bilastine in the management of allergic rhinitis and urticaria.

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治疗过敏性鼻结膜炎和荨麻疹的比拉斯汀:一项国际德尔菲研究的结果。
背景:包括比拉斯汀在内的第二代口服 H1 抗组胺药是治疗成人和儿童过敏性鼻炎(包括鼻结膜炎)和慢性荨麻疹的新兴药物。本研究分析了支持使用第二代抗组胺药中的比拉斯汀对成人和儿童过敏性鼻炎和荨麻疹进行对症治疗的现有证据:方法:来自 17 个国家的专家就鼻炎和荨麻疹的理想治疗方法以及比拉斯汀的具体作用达成了共识。专家们采用李克特五点量表(1 = 非常不同意;2 = 不同意;3 = 未决定;4 = 同意;5 = 非常同意)对总共 12 项陈述进行了投票。共识的定义是 4+5 分(同意或非常同意)至少 80% 一致:结果:所有建议声明都达成了共识,其中 5 项声明的一致性≥98%,7 项声明的一致性≥96%:结论:拟议声明获得的广泛共识表明,比拉斯汀在过敏性鼻炎和荨麻疹的治疗中发挥着重要作用。
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来源期刊
Drugs in Context
Drugs in Context Medicine-Medicine (all)
CiteScore
5.90
自引率
0.00%
发文量
63
审稿时长
9 weeks
期刊介绍: Covers all phases of original research: laboratory, animal and human/clinical studies, health economics and outcomes research, and postmarketing studies. Original research that shows positive or negative results are welcomed. Invited review articles may cover single-drug reviews, drug class reviews, latest advances in drug therapy, therapeutic-area reviews, place-in-therapy reviews, new pathways and classes of drugs. In addition, systematic reviews and meta-analyses are welcomed and may be published as original research if performed per accepted guidelines. Editorials of key topics and issues in drugs and therapeutics are welcomed. The Editor-in-Chief will also consider manuscripts of interest in areas such as technologies that support diagnosis, assessment and treatment. EQUATOR Network reporting guidelines should be followed for each article type. GPP3 Guidelines should be followed for any industry-sponsored manuscripts. Other Editorial sections may include Editorial, Case Report, Conference Report, Letter-to-the-Editor, Educational Section.
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