A decentralized solid compound storage facility managed by a centralized electronic platform at a growing drug discovery company

IF 2.5 4区 医学 Q3 BIOCHEMICAL RESEARCH METHODS SLAS Technology Pub Date : 2024-05-11 DOI:10.1016/j.slast.2024.100143
Ting Qin, Sergio Ernesto Ruiz Hernandez, Jason Shiers, Matthew Crittall, Andrew Novak, Colin Sambrook Smith
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Abstract

Within a growing drug discovery company, scientists acquire (either through in house synthesis or purchase) then store, retrieve, and ship solid compound samples daily between multiple locations. The efficient management and tracking of this entire process to support drug discovery is a significant challenge. This article describes a decentralized and cost-effective inventory facility that simplifies the solid compound storage and retrieval process. Standardized storage cabinets from the market are utilized, providing a cost-effective physical infrastructure. The cabinets can be distributed across storage rooms at multiple sites and arranged into spaces with a variety of dimensions, allowing the system to be retrofitted into existing facilities and scaled up easily. We can provide storage close to work areas at each location, minimizing both unnecessary movement of staff and transportation of substances. We have applied a systematic barcoding method to the compound batch identifier that correlates with its compound location. This simplifies the compound registration process as well as the process of finding and returning compounds. Additionally, a centralized electronic platform has been employed to store, update and track solid compound information, such as properties, location and quantity. Compound shipment may be initiated from different sites, and a centralized electronic platform assists the information retrieval process, ensuring each location possesses up-to-date information. The electronic platform we present streamlines the management of compound registration, location tracking, weight updates and shipment information, facilitating seamless record sharing among all stakeholders. Every step of the process can be tracked in real time by the project team. The platform can be flexibly configured to adapt to an evolving set of storage locations, with all information and processes being audited.

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一家成长型药物研发公司的分散式固体化合物存储设施,由中央电子平台管理。
在一家不断发展壮大的药物研发公司中,科学家们每天都要在多个地点之间获取(通过内部合成或购买)固体化合物样品,然后进行存储、检索和运输。如何有效管理和跟踪整个流程以支持药物发现是一项重大挑战。本文介绍了一种可简化固体化合物存储和检索流程的分散式高性价比库存设施。利用市场上的标准化存储柜,可提供经济高效的物理基础设施。这些柜子可以分布在多个地点的储藏室中,并被安排在不同尺寸的空间内,从而使该系统可以很容易地改装到现有设施中并扩大规模。我们可以在每个地点的工作区附近提供存储空间,最大限度地减少不必要的人员流动和物质运输。我们对化合物批次标识符采用了系统条形码方法,使其与化合物位置相关联。这简化了化合物登记流程以及寻找和归还化合物的过程。此外,还采用了中央电子平台来存储、更新和跟踪固体化合物信息,如属性、位置和数量。化合物的运输可能从不同地点启动,中央电子平台可协助信息检索过程,确保每个地点都拥有最新信息。我们介绍的电子平台简化了化合物注册、位置跟踪、重量更新和装运信息的管理,便于所有利益相关者无缝共享记录。项目团队可实时跟踪流程的每一个步骤。该平台可灵活配置,以适应不断变化的存储地点,所有信息和流程均可审计。
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来源期刊
SLAS Technology
SLAS Technology Computer Science-Computer Science Applications
CiteScore
6.30
自引率
7.40%
发文量
47
审稿时长
106 days
期刊介绍: SLAS Technology emphasizes scientific and technical advances that enable and improve life sciences research and development; drug-delivery; diagnostics; biomedical and molecular imaging; and personalized and precision medicine. This includes high-throughput and other laboratory automation technologies; micro/nanotechnologies; analytical, separation and quantitative techniques; synthetic chemistry and biology; informatics (data analysis, statistics, bio, genomic and chemoinformatics); and more.
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