Dynamic free fraction: concept, methodology and impact on hepatic clearance prediction using the well-stirred model

IF 2.7 4区医学 Q2 PHARMACOLOGY & PHARMACY Drug Metabolism and Pharmacokinetics Pub Date : 2024-04-01 DOI:10.1016/j.dmpk.2023.100821

Li Ma, Pasquale Carione, Julie Huang, Nicky Hwang, Zhengyin Yan

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动态游离分数：概念、方法及其对使用井式搅拌模型预测肝清除率的影响

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来源期刊

Drug Metabolism and Pharmacokinetics 医学-药学

CiteScore

4.80

自引率

9.50%

发文量

审稿时长

69 days

期刊介绍： DMPK publishes original and innovative scientific papers that address topics broadly related to xenobiotics. The term xenobiotic includes medicinal as well as environmental and agricultural chemicals and macromolecules. The journal is organized into sections as follows: - Drug metabolism / Biotransformation - Pharmacokinetics and pharmacodynamics - Toxicokinetics and toxicodynamics - Drug-drug interaction / Drug-food interaction - Mechanism of drug absorption and disposition (including transporter) - Drug delivery system - Clinical pharmacy and pharmacology - Analytical method - Factors affecting drug metabolism and transport - Expression of genes for drug-metabolizing enzymes and transporters - Pharmacogenetics and pharmacogenomics - Pharmacoepidemiology.

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