Functional Localization of the Human Auditory and Visual Thalamus Using a Thalamic Localizer Functional Magnetic Resonance Imaging Task.

John C Williams, Philip N Tubiolo, Zu Jie Zheng, Eilon B Silver-Frankel, Dathy T Pham, Natalka K Haubold, Sameera K Abeykoon, Anissa Abi-Dargham, Guillermo Horga, Jared X Van Snellenberg
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Abstract

Functional magnetic resonance imaging (fMRI) of the auditory and visual sensory systems of the human brain is an active area of investigation in the study of human health and disease. The medial geniculate nucleus (MGN) and lateral geniculate nucleus (LGN) are key thalamic nuclei involved in the processing and relay of auditory and visual information, respectively, and are the subject of blood-oxygen-level-dependent (BOLD) fMRI studies of neural activation and functional connectivity in human participants. However, localization of BOLD fMRI signal originating from neural activity in MGN and LGN remains a technical challenge, due in part to the poor definition of boundaries of these thalamic nuclei in standard T1-weighted and T2-weighted magnetic resonance imaging sequences. Here, we report the development and evaluation of an auditory and visual sensory thalamic localizer (TL) fMRI task that produces participant-specific functionally-defined regions of interest (fROIs) of both MGN and LGN, using 3 Tesla multiband fMRI and a clustered-sparse temporal acquisition sequence, in less than 16 minutes of scan time. We demonstrate the use of MGN and LGN fROIs obtained from the TL fMRI task in standard resting-state functional connectivity (RSFC) fMRI analyses in the same participants. In RSFC analyses, we validated the specificity of MGN and LGN fROIs for signals obtained from primary auditory and visual cortex, respectively, and benchmark their performance against alternative atlas- and segmentation-based localization methods. The TL fMRI task and analysis code (written in Presentation and MATLAB, respectively) have been made freely available to the wider research community.

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利用丘脑定位器功能磁共振成像任务对人类听觉和视觉丘脑进行功能定位
人脑听觉和视觉感觉系统的功能磁共振成像(fMRI)是人类健康和疾病研究中一个活跃的研究领域。内侧膝状核(MGN)和外侧膝状核(LGN)是丘脑的关键核团,分别参与听觉和视觉信息的处理和传递,是血氧水平依赖性(BOLD)fMRI 研究的对象,用于研究人类参与者的神经激活和功能连接。然而,源于 MGN 和 LGN 神经活动的 BOLD fMRI 信号的定位仍然是一项技术挑战,部分原因是这些丘脑核在标准 T1 加权和 T2 加权磁共振成像序列中的边界界定不清。在此,我们报告了听觉和视觉丘脑定位器 (TL) fMRI 任务的开发和评估情况,该任务使用 3 特斯拉多波段 fMRI 和聚类稀疏时间采集序列,在不到 16 分钟的扫描时间内产生了 MGN 和 LGN 参与者特定功能定义的感兴趣区 (fROIs)。我们演示了如何将从 TL fMRI 任务中获得的 MGN 和 LGN fROIs 用于同一参与者的标准静息态功能连接 (RSFC) fMRI 分析。在 RSFC 分析中,我们验证了 MGN 和 LGN fROIs 对分别从初级听觉皮层和视觉皮层获得的信号的特异性,并将其性能与其他基于图谱和分割的定位方法进行了比较。TL fMRI 任务和分析代码(分别用 Presentation 和 MATLAB 编写)已免费提供给更广泛的研究团体。
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