A comprehensive review of the Desmodium genus: An innovative exploration of its phytopharmacological characteristics, hepatoprotective capabilities, underlying mechanisms of action and possible applications

IF 7.3 2区 生物学 Q1 PLANT SCIENCES Phytochemistry Reviews Pub Date : 2024-05-11 DOI:10.1007/s11101-024-09963-7
Anju Rani George, Aarthi Jeganathan, Anju Byju, Sradha Sajeev, Kavimani Thangasamy, Paulpandi Manickam, Geetha Natesan
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Abstract

Liver disease is a significant global health concern, leading to around two million fatalities annually. This disorder encompasses a broad range of causes, including both well-established factors such as lifestyle choices, as well as less understood origins such as pre-existing medical diseases. In the present scenario, liver cancer poses a significant worldwide health concern, with projections indicating that the number of cases is expected to exceed one million by the year 2025. According to the World Health Organization, numerous developing nations, such as India, continue to rely on the utilization of plants and plant-derived substances for the treatment of diverse ailments. Desmodium Desv., a genus within the Fabaceae family, encompasses about 350 species that are primarily found in tropical and subtropical regions worldwide. These plants have a long-standing history of traditional medicinal use in India, Thailand, and China, particularly for the treatment of liver diseases. The objective of this review is to provide a comprehensive overview of the ethnobotanical applications, phytoconstituents, and hepatoprotective properties associated with all species of Desmodium. The research employed various methodologies. Data on the Desmodium genus was collected up until the year 2022 through the examination of research articles, patents, and diverse online bibliographic databases such as PubMed, Research Gate, PubChem, Science Direct, Scopus, Wiley Online Library, Web of Science, eOL, POWO, and IUCN. The online search was conducted using the following keywords: Desmodium species, review articles, ethnobotanical uses, phytochemical constituents, and hepatoprotective property. In conclusion, it can be inferred that Ethnobotanical research has revealed that these particular species possess diverse pharmacological attributes, including anti-oxidant, anti-inflammatory, anti-bacterial, cytotoxic, and hepatoprotective activities. The analysis of phytochemistry reveals the presence of various compounds such as flavonoids, alkaloids, terpenoids, steroids, phenols, and other constituents inside these species. Out of a total of 350 species, it has been observed that 18 possess hepatoprotective properties. In order to substantiate the hepatoprotective applications and advance the development of prominent pharmaceuticals, additional pharmacological investigations including animal models and phytochemical explorations are necessary.

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Desmodium 属的全面综述:对其植物药理学特征、保肝能力、基本作用机制和可能应用的创新性探索
肝病是全球关注的重大健康问题,每年导致约 200 万人死亡。这种疾病的病因非常广泛,既包括生活方式选择等公认的因素,也包括原有的内科疾病等不太为人所知的病因。目前,肝癌已成为世界范围内的一个重大健康问题,据预测,到 2025 年,肝癌病例预计将超过 100 万。据世界卫生组织称,印度等许多发展中国家继续依赖利用植物和植物衍生物质来治疗各种疾病。Desmodium Desv.是豆科植物中的一个属,约有 350 个品种,主要分布在世界各地的热带和亚热带地区。这些植物在印度、泰国和中国有着悠久的传统药用历史,特别是在治疗肝脏疾病方面。本综述旨在全面概述与所有 Desmodium 品种相关的民族植物学应用、植物成分和保肝特性。研究采用了多种方法。通过研究文章、专利和各种在线文献数据库,如 PubMed、Research Gate、PubChem、Science Direct、Scopus、Wiley Online Library、Web of Science、eOL、POWO 和 IUCN,收集了 Desmodium 属截至 2022 年的数据。在线搜索使用了以下关键词:Desmodium物种、综述文章、民族植物学用途、植物化学成分和肝脏保护特性。总之,可以推断出民族植物学研究发现这些特定物种具有多种药理特性,包括抗氧化、抗炎、抗菌、细胞毒性和保肝活性。植物化学分析显示,这些物种含有多种化合物,如黄酮类、生物碱、萜类、类固醇、酚类和其他成分。据观察,在总共 350 种植物中,有 18 种具有保护肝脏的特性。为了证实这些植物的保肝作用,并推动杰出药物的开发,有必要进行更多的药理学研究,包括动物模型和植物化学探索。
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来源期刊
Phytochemistry Reviews
Phytochemistry Reviews PLANT SCIENCES-
CiteScore
16.30
自引率
2.60%
发文量
54
审稿时长
2 months
期刊介绍: Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.
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