Michela De Lucia, Paola Orlandini, Daria Denti, Laura Berto, Giorgia Mezzalira, Andrea Peserico, Anna Belloni Fortina
{"title":"Ciclosporin‐responsive pyoderma in dogs: A comparison to human pyoderma gangrenosum","authors":"Michela De Lucia, Paola Orlandini, Daria Denti, Laura Berto, Giorgia Mezzalira, Andrea Peserico, Anna Belloni Fortina","doi":"10.1002/vrc2.894","DOIUrl":null,"url":null,"abstract":"We describe 20 cases of canine pyoderma responsive to immunosuppressive treatments and resembling human pyoderma gangrenosum. All dogs presented with a rapidly evolving, focal to multifocal, painful ulcerative dermatitis, non‐responsive to multiple antibiotic and anti‐inflammatory therapies. Elevations of C‐reactive protein (100%), neutrophilia (75%) and fever (25%) were also present. Histopathology showed a severe, ulcerative, superficial to deep, predominantly neutrophilic dermatitis. Bacterial infection was the most challenging differential diagnosis. Resolution of the lesions was obtained within 4–8 weeks in 83% of dogs treated with ciclosporin. Maintenance treatment was required in the majority of the dogs.","PeriodicalId":23496,"journal":{"name":"Veterinary Record Case Reports","volume":null,"pages":null},"PeriodicalIF":0.3000,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary Record Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/vrc2.894","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
We describe 20 cases of canine pyoderma responsive to immunosuppressive treatments and resembling human pyoderma gangrenosum. All dogs presented with a rapidly evolving, focal to multifocal, painful ulcerative dermatitis, non‐responsive to multiple antibiotic and anti‐inflammatory therapies. Elevations of C‐reactive protein (100%), neutrophilia (75%) and fever (25%) were also present. Histopathology showed a severe, ulcerative, superficial to deep, predominantly neutrophilic dermatitis. Bacterial infection was the most challenging differential diagnosis. Resolution of the lesions was obtained within 4–8 weeks in 83% of dogs treated with ciclosporin. Maintenance treatment was required in the majority of the dogs.
期刊介绍：
Vet Record Case Reports is an online resource that publishes articles in all fields of veterinary medicine and surgery so that veterinary professionals, researchers and others can easily find important information on both common and rare conditions. Articles may be about a single animal, herd, flock or other group of animals managed together. Common cases that present a diagnostic, ethical or management challenge, or that highlight aspects of mechanisms of injury, pharmacology or histopathology are deemed of particular educational value. All articles are peer reviewed and copy edited before publication.
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