Metastatic cholangiocarcinoma in a cow presenting as suspect bovine tuberculosis in Ireland

IF 0.3 Q4 VETERINARY SCIENCES Veterinary Record Case Reports Pub Date : 2024-09-18 DOI:10.1002/vrc2.998
Janne M. Schoening, Conor G. McAloon, Hanne Jahns
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Abstract

Cholangiocarcinoma is a malignant tumour of bile duct epithelial cells, an uncommon primary hepatic neoplasm in cattle. A 9‐year‐old Simmental cow presented with watery diarrhoea, crusty skin lesions, loss of appetite and hepatomegaly. Suspecting severe liver disease, the cow was euthanased due to poor prognosis. During gross postmortem examination, large numbers of multifocal to coalescing nodules often with soft necrotic centres ranging from miliary to 7 cm in size were present in the liver, lung, mesentery, peritoneum and lymph nodes. These features were suggestive of bovine tuberculosis. However, direct tissue smears stained by Ziehl Neelsen stain were negative for the presence of acid‐fast bacteria, and subsequent histopathological and immunohistochemical investigations confirmed the presence of metastasizing cholangiocarcinoma. This case reminds clinicians and pathologists to keep an open mind during the diagnostic process and serves to highlight the value of histopathology in diagnosing seemingly characteristic gross lesions.
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爱尔兰一头疑似牛结核病奶牛的转移性胆管癌
胆管癌是胆管上皮细胞的恶性肿瘤,是牛不常见的原发性肝肿瘤。一头 9 岁的西门塔尔牛出现水样腹泻、皮肤结痂、食欲不振和肝肿大。由于怀疑患有严重肝病,该牛因预后不良而被安乐术。在尸体解剖时,在肝脏、肺、肠系膜、腹膜和淋巴结中发现了大量多灶性至凝聚性结节,通常伴有软性坏死中心,大小从米粒至 7 厘米不等。这些特征表明是牛结核病。然而,经齐氏染色法(Ziehl Neelsen stain)染色的直接组织涂片显示,耐酸细菌呈阴性,随后的组织病理学和免疫组化检查证实了转移性胆管癌的存在。这个病例提醒临床医生和病理学家在诊断过程中要保持开放的心态,并突出了组织病理学在诊断看似特征性的大体病变方面的价值。
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来源期刊
Veterinary Record Case Reports
Veterinary Record Case Reports Veterinary-Veterinary (all)
CiteScore
0.50
自引率
33.30%
发文量
266
期刊介绍: Vet Record Case Reports is an online resource that publishes articles in all fields of veterinary medicine and surgery so that veterinary professionals, researchers and others can easily find important information on both common and rare conditions. Articles may be about a single animal, herd, flock or other group of animals managed together. Common cases that present a diagnostic, ethical or management challenge, or that highlight aspects of mechanisms of injury, pharmacology or histopathology are deemed of particular educational value. All articles are peer reviewed and copy edited before publication.
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