Lopamudra Mishra, Lakshmi Kumari, Yash Sharma, Kanak Chahar, Mritunjay Kumar, Preeti Patel, Ghanshyam Das Gupta, Balak Das Kurmi
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引用次数: 0
Abstract
Lung cancer is a complicated thoracic malignancy globally, resulting in molecular, biomolecular, and signaling pathway abnormalities. It is the most lethal form of cancer among males and females of all age groups. The annual incidence rate is 12%, and the death rate is 15% reported. The paradigm of gloomy diagnosis in the early stage of the diseases and metastatic/resistant tumor cell populations reinforces the necessary multidisciplinary advanced adaptive research procedures like molecular targeting and nanotechnology. This review emphasizes pivotal research on advanced novel treatment strategies for the management of lung cancer and under this, the application of molecular targeting, i.e., EGFR inhibitors, BRAF inhibitors, MEK inhibitors, ROS1 inhibitors, and ALK inhibitors with nanocarrier approaches such as liposomes, quantum dots, polymeric nanoparticles, biomimetic nanocarriers, and SLNs has been described. In the nanotechnology approach, the tremendous role of nanoparticles as drug carriers, bionanocarriers, and nanotheranostics is briefly illustrated.
期刊介绍：
The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size.
Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology.
The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.
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